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Establishment of novel targeted therapy by inhibition of Notch signaling pathway in biliary tract cancer

Research Project

Project/Area Number 23791514
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionTohoku University

Principal Investigator

MIZUMA Masamichi  東北大学, 大学病院, 助教 (80578675)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
KeywordsNotch / 癌幹細胞様細胞 / 胆管癌
Research Abstract

Although Notch signaling pathway is related to various malignancies, it is unclear whether it influences cancer of the biliary tract. In the present study, it was clarified that expression of Notch signaling pathway proteins in immunohistochemistry was seen in some resected cases with extrahepatic cholangiocarcinoma. The results of this study suggest influence of Notch signaling on extrahepatic cholangiocarcinoma.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (4 results)

All 2013 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Potential utility of eGFP-expressing NOG mice (NOG-EGFP) as a high purity cancer sampling system2012

    • Author(s)
      Shima K, et al
    • Journal Title

      J Exp Clin Cancer Res

      Volume: 31 Issue: 1 Pages: 55-61

    • DOI

      10.1186/1756-9966-31-55

    • URL

      http://www.jeccr.com/content/31/1/55

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 蛍光NOGマウスの異種移植モデルを用いた高純度癌細胞サンプリングシステム2013

    • Author(s)
      嶋健太郎、水間正道、ほか
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2013-04-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Utility of xenograft models using NOG-eGFP mice for a high quality sampling system of Pancreato-Biliary cancer cells2012

    • Author(s)
      Shima K, Mizuma M, et al
    • Organizer
      International Hepato-Pancreato Biliary Association 2012
    • Place of Presentation
      Paris , France
    • Year and Date
      2012-07-03
    • Related Report
      2013 Final Research Report
  • [Presentation] An attempt to establish a high quality sampling system of cancer cells using a xenograft model of NOG-EGFP mice2011

    • Author(s)
      嶋健太郎、水間正道、ほか
    • Organizer
      第70回日本癌学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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