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Pin1 is decreased in ischemically damaged liver and suppressed liver regeneration after hepatectomy through the inhibition of Pin1-mediated NF-kappaB activation in hepatocytes.

Research Project

Project/Area Number 23791516
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionChiba University

Principal Investigator

KUBOKI Satoshi  千葉大学, 医学部附属病院, 助教 (50571410)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords肝臓外科学 / 術後肝再生
Research Abstract

Pin1 was degraded in severe damaged liver, therefore, regeneration was suppressed through decreased activation of NF-kappaB. In contrast, Pin1 expression was maintained in mild damaged liver. Therefore, Pin1 bound to NF-kappaB-p65 and generated Pin1-NF-kappaB-p65 complex. This complex activated NF-kappaB and induced liver regeneration. Moreover, cell proliferation was inhibited in severe damaged hepatocyte induced by H2O2 stimulation in vitro, through decreased expression of Pin1 and Pin1-NF-kappaB-p65 complex and decreased activation of NF-kappaB. In conclusion, Pin1 is an important endogenous regulator of liver regeneration in severe damaged liver,and is a potential therapeutic target for liver failure after extended hepatectomy.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (10 results)

  • [Journal Article] Chylous Ascites After Hepato-Pancreato-Biliary Surgery2013

    • Author(s)
      Kuboki S, et al
    • Journal Title

      Br J Surg

      Volume: 100(4) Pages: 522-527

    • Related Report
      2012 Final Research Report
  • [Journal Article] Chylous ascites after hepatopancreatobiliary surgery2013

    • Author(s)
      Kuboki S, Yoshidome H, et al.
    • Journal Title

      Br J Surg

      Volume: 100 Issue: 4 Pages: 522-527

    • DOI

      10.1002/bjs.9013

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 「炎症と消化器癌」肝におけるPPAR-gamma活性亢進に伴う抗炎症作用の解明及び肝細胞癌におけるPPAR-gamma発現の意義2012

    • Author(s)
      久保木知, 他
    • Journal Title

      消化器内科

      Volume: 54(6) Pages: 739-743

    • Related Report
      2012 Final Research Report
  • [Presentation] Pin1 is decreased in ischemically damaged liver and suppressed liver regeneration after hepatectomy through the inhibition of Pin1-mediated NF-kappaB activation in hepatocytes2013

    • Author(s)
      Kuboki S, et al
    • Organizer
      48^<th> EASL 2013 (Oral e-poster session 選出)
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2012 Final Research Report
  • [Presentation] 阻血障害肝切除後の転写因子活性抑制に伴う肝再生遅延機序へのPinlの関与の解明及びその対策2013

    • Author(s)
      久保木知, 他
    • Organizer
      第113回日本外科学会総会
    • Place of Presentation
      パネルディスカッション
    • Related Report
      2012 Final Research Report
  • [Presentation] Inhibitory effects of peroxisome proliferator-activated receptor-gamma on tumor growth in human hepatocellular carcinoma: Usefulness as a prognostic predictor and therapeutic target2012

    • Author(s)
      Kuboki S, et al
    • Organizer
      DDW 2013 (Poster session)
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝でのPin1を介したNF-kappaB活性とPPAR-gamma活性の均衡調節による酸化ストレス制御及び抗Pin1抗体の肝細胞癌に対する腫瘍増殖抑制機序の解明2012

    • Author(s)
      久保木知, 他
    • Organizer
      JDDW2012
    • Place of Presentation
      パネルディスカッション
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝細胞癌における抗Pin1抗体のNF-kappaB活性抑制とPPAR-gamma活性亢進を介した腫瘍増殖抑制機序の解明及び分子標的治療薬としての可能性の追求2012

    • Author(s)
      久保木知, 他
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      ワークショップ
    • Related Report
      2012 Final Research Report
  • [Presentation] 拡大肝切除及び肝移植術後の阻血障害肝再生抑制に伴う肝不全発生機序の解明及びその対策2012

    • Author(s)
      久保木知, 他
    • Organizer
      第112回日本外科学会総会
    • Place of Presentation
      サージカルフォーラム
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝におけるPPAR-gamma活性亢進に伴う抗炎症作用の解明および肝細胞癌におけるPPAR-gamma発現の意義の検討2011

    • Author(s)
      久保木知, 他
    • Organizer
      JDDW2011
    • Place of Presentation
      シンポジウム
    • Related Report
      2012 Final Research Report
  • [Presentation] 拡大肝切除及び肝移植術後の阻血障害肝再生抑制に伴う肝不全発生機序の解明及びその対策

    • Author(s)
      久保木 知
    • Organizer
      第112回日本外科学会総会(サージカルフォーラム)
    • Place of Presentation
      千葉(幕張)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 阻血障害肝における切除後の転写因子活性抑制に伴う肝再生遅延機序へのPin1 の関与の解明及びその対策

    • Author(s)
      久保木 知
    • Organizer
      第113回日本外科学会総会(パネルディスカッション)
    • Place of Presentation
      福岡(博多)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Pin1 is decreased in ischemically damaged liver and suppressed liver regeneration after hepatectomy through the inhibition of Pin1-mediated NF-kB activation in hepatocytes.

    • Author(s)
      Satoshi Kuboki
    • Organizer
      48th EASL、oral e-Poster presentation
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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