MicroRNA expression analysis of the gastric cancer peritoneal carcinomatosis
| Project/Area Number |
23791525
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Mie University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 胃十二指腸外科学 / 胃癌 / 腹膜播種 / microRNA / マイクロRNA |
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| Research Abstract |
Establishment of metastasis mechanism contributes greatly to improving prognosis. The aim of this study is to clarify the significance of miRNA / mRNA expression profile in gastric cancer tissues and to clarify the mechanism of peritoneal metastasis in gastric cancer. MiR151-5p expression analysis in cancer tissue and adjascent normal mucosa in gastric cancer patientsdemonstrated that overexpression of miR151-5p was significantly correlated with synchronous peritoneal metastasis and poor prognosis in gastric cancer patients. In vitro analysis,downregulation of miR151-5p suppressed the proliferation and invasive ability in gastric cancer cells. On the other hand, we have demonstrated that brain derived neurotrophic factor / tropomyosin-related kinase B pathway is deeply involved in the formation of peritonealmetastasis in the gastric cancer.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Brain-derived neurotrophic factor /tropomyosin -related kinase B pathway in gastric cancer.2013
Author(s)
Okugawa Y, Tanaka K, Inoue Y, Kawamura M, Kawamoto A, Hiro J, Saigusa S, Toiyama Y, Ohi M, Uchida K, Mohri Y, Kusunoki M.
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Journal Title
Br J Cancer
Volume: 108(1)
Pages: 121-30
Related Report
Peer Reviewed
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[Journal Article] Clinical significance of Zinc finger E-box Binding homeobox 1 (ZEB1) in human gastric cancer2012
Author(s)
Okugawa Y, Toiyama Y, Tanaka K, Matsusita K, Fujikawa H, Saigusa S, Ohi M, Inoue Y, Mohri Y, Uchida K, Kusunoki M.
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Journal Title
J Surg Oncol
Volume: 106(3)
Pages: 280-5
Related Report
Peer Reviewed
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[Journal Article] CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer2012
Author(s)
Kawamura M, Toiyama Y, Tanaka K, Saigusa S, Okugawa Y, Hiro J, Uchida K, Mohri Y, Inoue Y, Kusunoki M
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Journal Title
Eur J Cancer
Volume: 48(14)
Pages: 2244-51
Related Report
Peer Reviewed
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