| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Establishment of metastasis mechanism contributes greatly to improving prognosis. The aim of this study is to clarify the significance of miRNA / mRNA expression profile in gastric cancer tissues and to clarify the mechanism of peritoneal metastasis in gastric cancer. MiR151-5p expression analysis in cancer tissue and adjascent normal mucosa in gastric cancer patientsdemonstrated that overexpression of miR151-5p was significantly correlated with synchronous peritoneal metastasis and poor prognosis in gastric cancer patients. In vitro analysis,downregulation of miR151-5p suppressed the proliferation and invasive ability in gastric cancer cells. On the other hand, we have demonstrated that brain derived neurotrophic factor / tropomyosin-related kinase B pathway is deeply involved in the formation of peritonealmetastasis in the gastric cancer.
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