New stromal management to focus on senescence and induction of pancreatic mesenchymal stem cells

• Project/Area Number: 23791542
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: MIYASAKA Yoshihiro 九州大学, 医学研究院, 共同研究員 (40507795)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 膵癌 / セネセンス / 問葉系幹細胞 / デスモプレジア / 癌間質相互作用 / 間葉系幹細胞 / desmoplasia

Research Abstract

In pancreatic cancer tissue, few stromal cells expressed senescence markers. Senescence in stromal cells might be inhibited due to interaction between mesenchymal stem cells and normal stromal cells. The cells of intraductal papillary mucinous neoplasm of

Research Products

• [Journal Article] Pirfenidone Inhibits Pancreatic Cancer Desmoplasia by Regulating Stellate Cells (2013)
  • Author(s): Kozono S, Ohuchida K, Eguchi D, Ikenaga N, Fujiwara K, Cui L, Mizumoto K, Tanaka M.
  • Journal Title: Cancer Res. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Pirfenidone Inhibits Pancreatic Cancer Desmoplasia by Regulating Stellate Cells. (2013)
  • Author(s): Kozono S
  • Journal Title: Cancer Research Volume: 未定
  • Peer Reviewed
• [Journal Article] Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer (2012)
  • Author(s): Zhao M, Tominaga, Ohuchida K, Mizumoto K, Cui L, Kozono S, Fujita H, Maeyama R, Toma H, Tanaka M
  • Journal Title: Cancer Sci Volume: 103(1) Pages: 58-66
  • Peer Reviewed
• [Journal Article] CD271 + subpopulation of pancreatic stellate cells correlates with prognosis of pancreatic cancer and is regulated by interaction with cancer cells (2012)
  • Author(s): Fujiwara K, Ohuchida K, Mizumoto K, Shindo K, Eguchi D, Kozono S, Ikenaga N, Ohtsuka T, Takahata S, Aishima S, Tanaka M.
  • Journal Title: PLoS One. Volume: 7(12)
  • Peer Reviewed
• [Journal Article] Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer. (2012)
  • Author(s): Zhao M
  • Journal Title: Cancer Science Volume: 103 Pages: 58-66
  • Peer Reviewed
• [Journal Article] CD271^+ subpopulation of pancreatic stellate cells correlates with prognosis of pancreatic cancer and is regulated by interaction with cancer cells (2012)
  • Author(s): Kenji Fujiwara
  • Journal Title: PLoS One Volume: 12 Issue: 12 Pages: e52682-e52682
  • DOI: 10.1371/journal.pone.0052682
  • Peer Reviewed
• [Journal Article] Senescence in intraductal papillary mucinous neoplasm of the pancreas (2011)
  • Author(s): Miyasaka Y, Nagai E, Ohuchida K, Fujita H, Nakata K, Hayashi A, Mizumoto K, Tsuneyoshi M, Tanaka M
  • Journal Title: Hum Pathol. Volume: 42(12) Pages: 2010-7
  • Peer Reviewed
• [Journal Article] Invasive carcinoma derived from intestinal-type intraductal papillary mucinous neoplasm is associated with minimal invasion, colloid carcinoma, and less invasive behavior, leading to a better prognosis. (2011)
  • Author(s): Nakata K, Ohuchida K, Aishima S, Sadakari Y, Kayashima T, Miyasaka Y, Nagai E, Mizumoto K, Tanaka M, Tsuneyoshi M, Oda Y.
  • Journal Title: Pancreas. Volume: 40(4) Pages: 581-7
  • Peer Reviewed
• [Journal Article] Clinicopathological features and prognosis of mucinous cystic neoplasm with ovarian-type stoma: a multi-institutional study of the Japan pancreas society. (2011)
  • Author(s): Yamao K, Yanagisawa A, Takahashi K, Kimura W, Doi R, Fukushima N, Ohike N, Shimizu M, Hatori T, Nobukawa B, Hifumi M, Kobayashi Y, Tobita K, Tanno S, Sugiyama M, Miyasaka Y, Nakagohri T, Yamaguchi T, Hanada K, Abe H, Tada M, Fujita N, Tanaka M.
  • Journal Title: Pancreas. Volume: 40(1) Pages: 67-71
  • Peer Reviewed
• [Journal Article] Senescence in intraductal papillary mucinous neoplasm of the pancreas. (2011)
  • Author(s): Miyasaka Y et al
  • Journal Title: Human Pathology Volume: 42 Pages: 2010-2017
  • Peer Reviewed
• [Journal Article] Invasive carcinoma derived from intestinal-type intraductal papillary mucinous neoplasm is associated with minimal invasion, colloid carcinoma, and less invasive behavior, leading to a better prognosis. (2011)
  • Author(s): Nakata K、Miyasaka Y et al
  • Journal Title: Pancreas Volume: 40 Pages: 581-587
  • Peer Reviewed
• [Presentation] Antifibrotic Agent, Pirfenidone, Inhibits Pancreatic Stellate Cells and Tumor-Stromal (2012)
  • Author(s): Shingo Kozono, Kenoki Ohuchida, Daiki Eguchi, Kenji Fujiwara, Ming Zhao, Lin Cui, Kazuhiro Mizumoto and Masao Tanaka
  • Organizer: Interaction in Pancreatic cancer 2012 Joint Meeting of American Pancreatic Association and International Association of Pancreatology
  • Place of Presentation: Miami, USA
  • Year and Date: 2012-11-01
• [Presentation] CD271+ pancreatic stellate cells are correlated with prognosis of patients with pancreatic cancer and regulated by interaction with cancer cells (2012)
  • Author(s): Kenji Fujiwara, Kenoki Ohuchida, Koji Shindo, Shingo Kozono, Naoki Ikenaga, Lin Cui, Shinichi Aishima, Masafumi Nakamura, Kazuhiro Mizumoto, Yoshinao Oda, Masao Tanaka
  • Organizer: International Symposium on Pancreas Cancer 2012
  • Place of Presentation: Kyoto
  • Year and Date: 2012-10-06
• [Presentation] Pirfenidoneによる膵星細胞を標的とした新しい膵癌治療の可能性 (2012)
  • Author(s): 小薗真吾、大内田研宙、水元一博、大塚隆生、赤川進、Ana Ines Cases、江口大樹、藤原謙次、趙茗、崔林、池永直樹、田中雅夫
  • Organizer: 第43回日本膵臓学会大会
  • Place of Presentation: 山形
  • Year and Date: 2012-06-29
• [Presentation] 膵癌におけるCD271陽性膵星細胞の意義 (2012)
  • Author(s): 藤原謙次,大内田研宙,進藤幸治,赤川進,江口大樹,小薗真吾,池永直樹,崔林,相島慎一,大塚隆生,高畑俊一,水元一博,小田義直,田中雅夫
  • Organizer: 第112回日本外科学会定期学術集会
  • Year and Date: 2012-04-13
• [Presentation] Pirfenidoneによる膵星細胞を標的とした新しい膵癌治療の可能性 (2012)
  • Author(s): 小薗真吾、大内田研宙、水元一博、田中雅夫
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2012-04-13