The elucidation of the novel microRNA-gene pathway regulating the peritoneal dissemination in gastric cancer
Project/Area Number |
23791550
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Digestive surgery
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Research Institution | Kumamoto University |
Principal Investigator |
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Research Collaborator |
BABA Hideo 熊本大学, 生命科学研究部, 教授 (20240905)
WATANABE Masayuki 熊本大学, 生命科学研究部, 准教授 (80254639)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | microRNA / 胃癌 / 腹膜播種 / 転移 / 化学療法耐性 / exosome / 消化器癌 / miR-21 |
Research Abstract |
The prognosis of the patients with peritoneal dissemination of gastric cancer still remains dismal. The molecular mechanism of peritoneal dissemination has been not elucidated. microRNA has been reported to be involved in carcinogenesis, progress, metastasis and chemo-resistance. In the current study, we aimed to reveal the novel microRNA- gene pathway in human serum samples regulating the malignant potential of gastrointestinal cancer.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis2013
Author(s)
Yokobori T, Iinuma H, Shimamura T,Imoto S, Sugimachi K, Ishii H, Iwatsuki M, Ota D, Ohkuma M, Iwaya T,Nishida N, Kogo R, Sudo T, Tanaka F,Shibata K, Toh H, Sato T, Barnard GF,Fukagawa T, Yamamoto S, Nakanishi H, Sasaki S, Miyano S, Watanabe T, Kuwano H, Mimori K, Pantel K, Mori M
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Journal Title
CancerRes
Volume: 73
Pages: 2059-69
Related Report
Peer Reviewed
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[Journal Article] Micro RNA- 200b regulates cellproliferation, invasion and migrationby directly targeting ZEB2 in gastriccarcinoma2012
Author(s)
Kurashige J, Kamohara H, Watanabe M,Hiyoshi Y, Iwatsuki M, Tanaka Y,Kinoshita K, Saito S, Baba Y, Baba H
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Journal Title
Ann Surg Oncol 19 Suppl
Volume: 3
Issue: S3
Pages: 656-64
DOI
Related Report
Peer Reviewed
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