Functional analysis of Wnt-related genes concerning invasion andmetastasis of pancreas cancer

Research Project

Project/Area Number	23791552
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Digestive surgery
Research Institution	University of Miyazaki
Principal Investigator	TAKAHASHI Nobuyasu 宮崎大学, 医学部, 助教 (20404436)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	Dkk-1 遺伝子 / Wnt 遺伝子 / Dkk-1遺伝子 / Wnt遺伝子 / DKK-1蛋白 / WNT蛋白 / DKK-1
Research Abstract	WNT protein have a multiple functions concerning cancer in vasionand metastasis. We investigated DKK-1 protein concentration in the pancreatic juice,which shows inhibitory ability against WNT protein, for an early detection of the pancreascancer . Although no correlation can be identified between DKK-1 concentration andpancreas cancer , DKK-1 mRNA expression is elevated in the bile duct cancer as well aspancreas cancer