Expression of epidermal growth factor receptor detected by cetuximab indicates its efficacy to inhibit in vitro and in vivo proliferation of colorectal cancer cells

• Project/Area Number: 23791559
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Keio University
• Principal Investigator: SHIGETA Kohei 慶應義塾大学, 医学部, 助教 (30528790)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 大腸癌 / 分子標的治療薬 / セツキシマブ

Research Abstract

Cetuximab is a monoclonal antibody of the IgG1 subclass that targets the human epidermal growth factor receptor (EGFR). We hypothesized that the expression levels of EGFR which can be detected by cetuximab itself may influence the inhibition of cell proli

Research Products

• [Journal Article] Expression of epidermal growth factor receptor detected by cetuximab indicates its efficacy to inhibit in vitro and in vivo proliferation of colorectal cancer cells (2013)
  • Author(s): Kohei Shigeta, Tetsu Hayashida, Yoshinori Hoshino, Koji Okabayashi, Takashi Endo, Yoshiyuki Ishii, Hirotoshi Hasegawa, Yuko Kitagawa
  • Journal Title: PLOS ONE Volume: 8(6) Issue: 6 Pages: e66302-e66302
  • DOI: 10.1371/journal.pone.0066302
  • Peer Reviewed
• [Journal Article] Expression of epidermal growth factor receptor detected by cetuximab indicates its efficacy to inhibit in vitro and in vivo proliferation of colorectal cancer cells (2013)
  • Author(s): Kohei Shigeta
  • Journal Title: PLOS ONE Volume: 不明
  • Peer Reviewed
• [Presentation] Expression of EGFR on membrane surface detected by cetuximab itself contributes to the efficacy of cetuximab in colorectal cancer cell (2013)
  • Author(s): Kohei Shigeta
  • Organizer: AACR/JCA joint conference 2013
  • Place of Presentation: Maui, Hawaii
  • Year and Date: 2013-02-24
• [Presentation] 大腸癌細胞膜表面EGFR の発現量とCetuximab感受性 (2012)
  • Author(s): 茂田 浩平
  • Organizer: 日本癌学会総会2012
  • Place of Presentation: 札幌 ポスター
  • Year and Date: 2012-09-20
• [Presentation] 大腸癌細胞膜表面EGFRとCetuximab感受性の相関 (2012)
  • Author(s): 茂田 浩平
  • Organizer: 日本癌転移学会総会2012
  • Place of Presentation: 広島ワークショップ6-3
  • Year and Date: 2012-07-13
• [Presentation] 大腸癌細胞膜表面EGFRとCetuximab感受性の相関
  • Author(s): 茂田 浩平
  • Organizer: 日本がん転移学会
  • Place of Presentation: 広島 ワークショップ6-3
• [Presentation] 大腸癌細胞膜表面EGFRの発現量とCetuximab感受性
  • Author(s): 茂田 浩平
  • Organizer: 日本癌学会
  • Place of Presentation: 札幌 ポスター
• [Presentation] セツキシマブにより検出されたEGFR発現量と薬剤感受性の相関の検討
  • Author(s): 茂田 浩平
  • Organizer: 日本消化器外科学会
  • Place of Presentation: 宮崎 企画関連口演 消化器癌個別化治療 6