Measurement of pulmonary arterial flow velocity and shear stress using synchrotron radiation pulmonary micro-angiography in pulmonary hypertension

• Project/Area Number: 23791560
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Thoracic surgery
• Research Institution: University of Tsukuba
• Principal Investigator: TOKUNAGA CHIHO 筑波大学, 医学医療系, 講師 (30451701)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 放射光微小血管撮影 / 肺高血圧症 / シアストレス / 血管内皮細胞障害 / 放射光微小血管撮像法 / シアーストレス / 高感度放射光微小血管撮影 / 高肺血流肺高血圧症 / 放射光微小血管撮影法

Research Abstract

Congenital heart disease with high pulmonary blood flow is frequently complicated by the development of irreversible pulmonary hypertension. Increased shear stress may play a key role to induce intimal and medial hypertrophy and increase vascular resistance. We performed the pulmonary angiography in high flow pulmonary hypertension rat model by using synchrotron radiation micro-angiography to visualize the pulmonary microvasculature and measure the pulmonary flow velocity. The velocity of pulmonary artery in the high flow pulmonary hypertension rat model was significantly increased compared with the control (82.3 plusminus 8.5 mm/sec vs. 46.1 plusminus 4.3 mm/sec, p<0.05). Synchrotron radiation micro-angiography was useful for measuring the pulmonary blood flow velocity. This newly developed technology may help to investigate the mechanism of vascular remodeling associated with high flow pulmonary hypertension.

Research Products

• [Journal Article] Effects of landiolol hydrochloride on intractable tachyarrhythmia after pediatric cardiac surgery (2013)
  • Author(s): C.Tokunaga, Y.Hiramatsu, S.Kanemoto, M.Takahashi-Igari, M.Abe, H.Horigome, Y.Sakakibara
  • Journal Title: The Annals of thoracic Surgery Volume: Vol. 95 Pages: 1685-1688
  • NAID: 120007136933
  • Peer Reviewed
• [Journal Article] Cardiac sympathetic activity assessed by heart rate variability indicates myocardial ischemia on cold exposure in diabetes (2013)
  • Author(s): K.Sasaki, S.Matsushita, F.Sato, C.Tokunaga, K.Hyodo, Y.Sakakibara
  • Journal Title: Annals of Vascular Disease Volume: Vol.6 Pages: 583-589
  • NAID: 130004488014
  • Peer Reviewed
• [Journal Article] Surgical removal of infected pacemaker leads without cardiopulmonary bypass after failed extraction using the Excimer Laser Sheath Extraction System (2012)
  • Author(s): C.Tokunaga, Y.Enomoto, F.Sato, S.Kanemoto, S.Matsushita, Y.Hiramatsu, K.Aonuma, Y.Sakakibara
  • Journal Title: Journal of artificial organs Volume: Vol.15 Pages: 94-98
  • NAID: 10030563533
  • Peer Reviewed
• [Presentation] Synchrotron radiation pulmonary micro-angiography to visualize pulmonary artery vasculature for measurement of pulmonary arterial flow velocity in a high pulmonary flow rat model (2013)
  • Author(s): C.Tokunaga, S.Matsushita, K.Hyodo, Y. Hiramatsu, Y.Sakakibara
  • Organizer: The thirteenth international conference on endothelin
  • Place of Presentation: Univeristy of Tsukuba Tokyo campus, Tokyo, Japan
  • Year and Date: 2013-09-11
• [Presentation] Synchrotron radiation pulmonary micro-angiography to visualize pulmonary artery vasculature for measurement of pulmonary arterial flow velocity in a high pulmonary flow rat model, (2013)
  • Author(s): Chiho Tokunaga, Shonosuke Matsushita, Kazuyuki Hyodo, Yuji Hiramatsu, Yuzuru Sakakibara
  • Organizer: The thirteenth international conference on endothelin.
  • Place of Presentation: Tokyo, Japan
• [Presentation] Synchrotron radiation pulmonary micro-angiography for measurement of pulmonary arterial flow velocity in a high pulmonaryflow rat model (2012)
  • Author(s): C.Tokunaga, S.Matsushita, K.Hyodo, Y. Hiramatsu, Y.Sakakibara
  • Organizer: American heart association scientific sessions 2012
  • Place of Presentation: Los Angeles convention center, Los Angeles, USA
  • Year and Date: 2012-11-16
• [Presentation] Synchrotron Radiation Pulmonary Micro-Angiography for Measurement of Pulmonary Arterial Flow Velocity in a High Pulmonary Flow Rat Model (2012)
  • Author(s): Chiho Tokunaga
  • Organizer: American heart association scientific sessions 2012
  • Place of Presentation: Los Angels convention center(USA)
• [Presentation] Measurement of pulmonary arterial flow velocity in a high flow pulmonary hypertension rat model using synchrotron radiation pulmonary micro-angiography (2011)
  • Author(s): C.Tokunaga, S.Matsushita, K. Hyodo, Y.Hiramatsu, Y.Sakakibara
  • Organizer: American heart association scientific sessions 2011
  • Place of Presentation: Orange county convention center, Orland, USA
  • Year and Date: 2011-11-06
• [Presentation] 高肺血流性肺高血圧ラットにおける高感度放射光微小血管撮影法を用いた肺動脈造影と肺動脈velocityの計測 (2011)
  • Author(s): 徳永千穂、坂本裕昭、相川志都、榎本佳治、佐藤藤夫、金本真也、野間美緒、松下昌之助、平松祐司、榊原謙
  • Organizer: 第64回日本胸部外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場、名古屋
  • Year and Date: 2011-10-12
• [Presentation] 高肺血流性肺高血圧ラットにおける高感度放射光微小血管撮影法を用いた肺動脈造影と肺動脈velocityの計測 (2011)
  • Author(s): 徳永千穂
  • Organizer: 第64 回日本胸部外科学会定期学術集会
  • Place of Presentation: 名古屋
• [Presentation] Measurement of pulmonary arterial flow velocity in a high flow pulmonary hypertension rat model using synchrotron radiation pulmonary micro-angiography (2011)
  • Author(s): Chiho Tokunaga
  • Organizer: American heart association scientific sessions 2011
  • Place of Presentation: (Orland, USA)
• [Book] 古くて新しい心臓病―成人先天性心疾患Eisenmenger症候群、成人病と生活習慣病 (2013)
  • Author(s): 徳永千穂
  • Total Pages: 218
  • Publisher: 東京医学社