Research Project
Grant-in-Aid for Young Scientists (B)
Malignant pleural mesothelioma (MPM) is a devastating disease with resistance to conventional therapies. We analyzed the effect of combined inhibition of MET and EGFR on malignant mesothelioma cell lines in vitro. And to test the effect of this combination in vivo, we established orthotopic xenograft models of human MPM cells and performed a preliminary experiment to administer inhibitors of MET and EGFR. We showed that combined inhibition of MET and EGFR exerted a stronger inhibitory effe ct on MPM cell proliferation in vivo.
All 2013 2012 2011
All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (27 results) Book (2 results)
Eur J Cardiothorac Surg
Volume: 43(4) Pages: 795-9
Gen Thorac Cardiovasc Surg
Volume: 61(2) Pages: 89-95
Eur J Cardiothorac Surg.
Volume: 43 Issue: 4 Pages: 795-9
10.1093/ejcts/ezs419
Gen Thorac Cardiovasc Surg.
Volume: 61 Issue: 2 Pages: 89-95
10.1007/s11748-012-0187-z
日本呼吸器外科学会雑誌
Volume: 27 Pages: 64-7
10031158799
J Thorac Cardiovasc Surg.
Volume: 144(2) Pages: 431-7
Am J Surg Pathol
Volume: 36(12) Pages: 1857-64
Volume: 42(6)
Volume: 144 Issue: 2 Pages: 431-7
10.1016/j.jtcvs.2012.05.069
Am J Surg Pathol.
Volume: 36 Issue: 12 Pages: 1857-64
10.1097/pas.0b013e31826320c4
Volume: 42 Issue: 6 Pages: 152-6
10.1093/ejcts/ezs527
Lung Cancer.
Volume: 74(2) Pages: 352-3
Surg Today.
Volume: 41(10) Pages: 1436-8
10030229063
Chest
Volume: 140(2) Pages: 527-8
Ann Thorac Surg.
Volume: 91 Issue: 6 Pages: 1973-5
10.1016/j.athoracsur.2010.11.067
