| Project/Area Number |
23791568
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 重症心不全 / 心筋線維化 / 補助人工心臓 / 細胞治療 / 心不全 / 細胞移植 / 線維芽細胞 |
|---|
| Research Abstract |
This study was to explore mechanisms related to improvement in cardiac function of advanced heart failure with a specific focus on fibrosis in the cardiac tissue. Firstly, cardiac tissue was surgically sampled from the patients having advanced heart failure at the time of left ventricular device implantation and at the time of cardiac transplantation. As a result, mechanical support by the device improved cardiac function but not reduced cardiac fibrosis. In contrast, regenerative treatment for a rat advanced heart failure model induced dynamic up-regulation and down-regulation of the factors related to synthesis and degradation of the fibrosis, consequently reducing cardiac fibrosis, indicating the importance of cardiac fibrosis in advanced heart failure.
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