Significant role of bone marrow derived cells in compensatory regenerative lung growth and wound healing.

Research Project

Project/Area Number	23791571
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Thoracic surgery
Research Institution	独立行政法人国立病院機構山ロ宇部医療センター (2012) National Hospital Organization,Yamaguchi - Ube Medical Center (2011)
Principal Investigator	TANAKA Toshiki 独立行政法人国立病院機構山ロ宇部医療センター, 臨床研究部, 医師 (50457305)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	呼吸器外科学 / 代償性肺再生 / 骨髄細胞 / 創傷治癒 / 骨髄由来幹細胞
Research Abstract	After left pneumonectomy, bone marrow-derived cells (BMCs) accumulated in the wound and contributed to tissue repair. This phenomenon was possibly addressed that BMCs was differentiated to myofibroblast and vascular endotjelial cells. BMCs which accumulated in the residual lung parenchyma after left pneumonectomy was possibly differentiated to alveolar cells and vascular endothelial cells, which would contribute to regeneration of lung tissue. BMCs would affect tissue repair during the lug regeneration.