The effect of Carbon monoxide and Adenosine receptor in bronchiolitis obliterans in mice trachea transplantation model.

• Project/Area Number: 23791577
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Thoracic surgery
• Research Institution: Keio University
• Principal Investigator: OHTSUKA Takashi 慶應義塾大学, 医学部, 講師 (40306717)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 肺移植 / 拒絶反応 / 一酸化炭素 / 急性肺障害

Research Abstract

Allografts treated with CORM-2 revealed a striking reduction of thickening in epithelial and subepithelial airway layers in trachea transplantation model compared with allografts treated with vehicle. These data implicate CORM-2-derived CO as a critical n

Research Products

• [Presentation] CORM-2のBOに対する抑制効果 (2013)
  • Author(s): 大塚 崇
  • Organizer: 日本呼吸器外科学会
  • Place of Presentation: 名古屋
• [Presentation] Wate-soluble carbon monoxide-releasing molecule attenuates allograft airway rejection (2012)
  • Author(s): Takashi Ohtsuka, Taichiro Goto, Masaki Anraku, Mitsutomo Kohno, Hiroaki Nomori
  • Organizer: International society of heart and lung transplantation
  • Place of Presentation: プラハ チェコ
  • Year and Date: 2012-04-17
• [Presentation] Carbon Monoxide-Releasing Molecule Attenuates Allograft Airway Rejection (2012)
  • Author(s): 大塚 崇
  • Organizer: International society of Heart and Lung transplantation
  • Place of Presentation: チェコ プラハ
• [Presentation] マウス気管移植(同所と異所)によるbronchiolitis obliterans モデルの検討Tracheal allograft oblitaration in a murine tracheal transplant model (2011)
  • Author(s): 大塚 崇、後藤太一郎、安樂 真樹、河野 光智、泉 陽太郎、堀之内宏久、野守 裕明
  • Organizer: 第64回日本胸部外科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-09