Research Project
Grant-in-Aid for Young Scientists (B)
The purpose of this study was to evaluate immune response in patients with non-small cell lung cancer (NSCLC) to overcome the tumor immune escape mechanism. The higher proportion of CD4+ CD25+ Foxp3+ regulatory T cells in the regional lymph node was a significant unfavorable prognostic factor, even in patients with node-negative NSCLC. The normal expression of HLA-class I was associated with a favorable prognosis in comparison with the heterogeneous expression group. It is necessary to evaluate the efficacy of adjuvant immunotherapy in consideration of clinical significance of the HLA expression pattern and the proportion of regulatory T cells.
All 2013 2012 2011
All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (13 results)
Eur J Cardiothorac Surg
Volume: 43(4) Pages: 759-64
Eur J Cardiothorac
Volume: 43 Pages: 759-64
Int J Clin Oncol
Volume: (Epub ahead of print)
Oncol Lett
Volume: 4(4) Pages: 625-630
J Surg Res
Oncol Lett.
Volume: 4 Pages: 625-630
Volume: 181 Pages: 57-63