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Analysis of immune response to overcome immune-escape of lung cancer

Research Project

Project/Area Number 23791580
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Thoracic surgery
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

SHIGEMATSU Yoshiki  産業医科大学, 医学部, 助教 (10546469)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords肺癌 / 腫瘍免疫 / 免疫逃避機構 / 制御性T細胞 / HLA / 制御性T細胞 / TGF-β / Foxp3 / 所属リンパ節 / HLA class I / Foxp 3 / 定量的PCR
Research Abstract

The purpose of this study was to evaluate immune response in patients with non-small cell lung cancer (NSCLC) to overcome the tumor immune escape mechanism. The higher proportion of CD4+ CD25+ Foxp3+ regulatory T cells in the regional lymph node was a significant unfavorable prognostic factor, even in patients with node-negative NSCLC. The normal expression of HLA-class I was associated with a favorable prognosis in comparison with the heterogeneous expression group. It is necessary to evaluate the efficacy of adjuvant immunotherapy in consideration of clinical significance of the HLA expression pattern and the proportion of regulatory T cells.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (20 results)

All 2013 2012 2011

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (13 results)

  • [Journal Article] Cancer/testis antigen expression as a predictor for epidermal growth factor receptor mutation and prognosis in lung adenocarcinoma2013

    • Author(s)
      Baba T, Shiota H, Kuroda K, Shigematsu Y, Ichiki Y, Uramoto H, Hanagiri T, Tanaka F
    • Journal Title

      Eur J Cardiothorac Surg

      Volume: 43(4) Pages: 759-64

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cancer/testis antigen expression as a predictor for epidermal growth factor receptor mutation and prognosis in lung adenocarcinoma.2013

    • Author(s)
      Baba T, Shiota H, Kuroda K, Shigematsu Y (4番目/8人中)
    • Journal Title

      Eur J Cardiothorac

      Volume: 43 Pages: 759-64

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Clinical significance of human leukocyte antigen loss and melanoma-associated antigen 4 expression in smokers of non-small cell lung cancer patients2012

    • Author(s)
      aba T, Shiota H, Kuroda K, Shigematsu Y, Ichiki Y, Uramoto H, Hanagiri T, Tanaka F
    • Journal Title

      Int J Clin Oncol

      Volume: (Epub ahead of print)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunosuppressive effect of regulatory T lymphocytes in lung cancer, with special reference to their effects on the induction of autologous tumor-specific cytotoxic T lymphocytes2012

    • Author(s)
      Shigematsu Y, Hanagiri T, Shiota H, Kuroda K, Baba T, Ichiki Y, Yasuda M, Uramoto H, Takenoyama M, Yasumoto K, Tanaka F
    • Journal Title

      Oncol Lett

      Volume: 4(4) Pages: 625-630

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic implications of human leukocyte antigen class I expression in patients who underwent surgical resection for non-small-cell lung cancer2012

    • Author(s)
      Hanagiri T, Shigematsu Y, Kuroda K, Baba T, Shiota H, Ichiki Y, Nagata Y, Yasuda M, Uramoto H, So T, Takenoyama M, Tanaka F
    • Journal Title

      J Surg Res

      Volume: (Epub ahead of print)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunosuppressive effect of regulatory T lymphocytes in lung cancer, with special reference to their effects on the induction of autologous tumor-specific cytotoxic T lymphocytes.2012

    • Author(s)
      Shigematsu Y
    • Journal Title

      Oncol Lett.

      Volume: 4 Pages: 625-630

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic implications of human leukocyte antigen class I expression in patients who underwent surgical resection for non-small-cell lung cancer.2012

    • Author(s)
      Hanagiri T, Shigematsu Y(2番目/12人中)
    • Journal Title

      J Surg Res

      Volume: 181 Pages: 57-63

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肺癌所属リンパ節における制御性T細胞および微小リンパ節転移の解析2012

    • Author(s)
      花桐 武志, 重松 義紀, 竹中 賢, 岡 壮一, 近石 泰弘, 下川 秀彦, 中川 誠, 永田 好香, 浦本 秀隆, 宗 知子, 田中 文啓
    • Organizer
      第50回日本癌治療学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] 肺癌所属リンパ節における制御性T細胞の臨床病理学的意義2012

    • Author(s)
      花桐 武志, 重松 義紀, 竹中 賢, 岡 壮一, 近石 泰弘, 下川 秀彦, 中川 誠, 永田 好香, 岩田 輝男, 浦本 秀隆, 宗 知子, 田中 文啓
    • Organizer
      第53回日本肺癌学会
    • Place of Presentation
      岡山コンベンションセンター、ホテルグランヴィア岡山、岡山市デジタルミュージアム、岡山全日空ホテル
    • Related Report
      2012 Final Research Report
  • [Presentation] 非小細胞肺癌における癌精巣抗原発現とワクチン療法への応用2012

    • Author(s)
      重松 義紀, 竹中 賢, 岡 壮一, 近石 泰弘, 馬場 哲郎, 下川 秀彦, 中川 誠, 浦本 秀隆, 宗 知子, 花桐 武志, 田中 文啓
    • Organizer
      第112回日本外科学会
    • Place of Presentation
      幕張メッセ、ホテルニューオータニ幕張
    • Related Report
      2012 Final Research Report
  • [Presentation] 非小細胞肺癌における腫瘍抗原およびHLA class Iの発現;癌特異的免疫療法への基盤的研究2012

    • Author(s)
      花桐武志,黒田耕志、重松義紀,永田好香,馬場哲郎,浦本秀隆,宗 知子,竹之山光広,田中文啓
    • Organizer
      第29回日本呼吸器外科学会
    • Place of Presentation
      秋田県民会館、秋田キャッスルホテル
    • Related Report
      2012 Final Research Report
  • [Presentation] 非小細胞肺癌における癌精巣抗原発現とワクチン療法への応用2012

    • Author(s)
      重松 義紀
    • Organizer
      第112回日本外科学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肺癌所属リンパ節における制御性T細胞および微小リンパ節転移の解析2012

    • Author(s)
      花桐 武志、重松 義紀(2番目/11人目)
    • Organizer
      第50回日本癌治療学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肺癌所属リンパ節における制御性T細胞の臨床病理学的意義2012

    • Author(s)
      花桐 武志、重松 義紀(2番目/11人目)
    • Organizer
      第53回日本肺癌学会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 非小細胞肺癌における腫瘍抗原およびHLA class Iの発現;癌特異的免疫療法への基盤的研究2012

    • Author(s)
      花桐 武志、黒田 耕志、重松 義紀(3番目/9人目)
    • Organizer
      第29回日本呼吸器外科学会
    • Place of Presentation
      秋田キャッスルホテル(秋田)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肺癌患者における制御性T細胞の発現と役割2011

    • Author(s)
      重松義紀, 黒田耕志, 馬場哲郎, 竹中賢, 近石泰弘, 岡壮一, 中川誠, 下川秀彦, 浦本秀隆, 宗知子, 花桐武志, 田中文啓
    • Organizer
      第39回日本臨床免疫学会
    • Place of Presentation
      京王プラザホテル
    • Related Report
      2012 Final Research Report
  • [Presentation] CHP-MAGE-A4 vaccine for patients with advanced lung cancer (Phase Istudy)2011

    • Author(s)
      (1)花桐武志, 重松義紀, 馬場哲郎, 永田好香, 浦本秀隆, 宗知子, 竹之山光広, 安元公正, 田中文啓, 影山慎一, 珠玖洋
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2011 Research-status Report
  • [Presentation] 肺癌患者における制御性T細胞の発現と役割2011

    • Author(s)
      (2)重松義紀, 黒田耕志, 馬場哲郎, 竹中賢, 近石泰弘, 岡壮一, 中川誠, 下川秀彦, 浦本秀隆, 宗知子, 花桐武志, 田中文啓
    • Organizer
      免疫疾患学会連合2011
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2011 Research-status Report
  • [Presentation] 新規悪性胸膜中皮腫関連抗原の機能解析と腫瘍マーカーとしての意義2011

    • Author(s)
      (3)重松義紀, 黒田耕志, 馬場哲郎, 竹中賢, 近石泰弘, 岡壮一, 中川誠, 下川秀彦, 浦本秀隆, 宗知子, 花桐武志, 田中文啓
    • Organizer
      第52回日本肺癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2011 Research-status Report
  • [Presentation] 悪性胸膜中皮腫に対する腫瘍特異的免疫応答の解析(第2報)2011

    • Author(s)
      (4)竹之山光広, 重松義紀, 馬場哲郎, 永田好香, 浦本秀隆, 宗知子, 花桐武志,田中文啓
    • Organizer
      第29回産業医科大学学会総会
    • Place of Presentation
      産業医科大学(北九州)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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