Analysis of ANP-mediated anti-metasitatic mechanism against lung cancer
| Project/Area Number |
23791581
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
NOJIRI Takashi 独立行政法人国立循環器病研究センター, 研究所, 流動研究員 (50570553)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ナトリウム利尿ペプチド / 肺癌 / がん転移 / 抗転移療法 / 癌転移 / 血管内皮細胞 / 癌微小環境 / ANP |
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| Research Abstract |
The objective of the present study was to investigate the mechanism of ANP in the prevention of cancer metastasis. In the B16/F10 hematogenous metastasis model, administration of ANP notably inhibited metastasis in the lung compared to the control mice. Furthermore, lung metastasis significantly increased in the vascular endothelial cell specific GC-A knock-out mice, and decreased in the vascular endothelial cell specific GC-A overexpression mice compared to the wild-type mice. These studies indicate that ANP/GC-A signaling in the vascular endothelial cells plays crucial roles in the inhibition of cancer metastasis. We found that ANP inhibits cancer metastasis through GC-A receptor in the vascular endothelial cells. Our data provide novel insights into the prophylactic therapy for various kinds of cancer metastasis.
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Report
(3 results)
Research Products
(24 results)
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[Presentation] Atrial natriuretic peptide protects against pulmonary inflammation2013
Author(s)
Takashi Nojiri, Hiroshi Hosoda, Takeshi Tokudome, Koichi Miura, Shin Ishikane, Toru Kimura, Masayoshi Inoue, Noriyoshi Sawabata, Kenji Kangawa, Meinoshin Okumura.
Organizer
21st European Conference on General Thoracic Surgery.
Place of Presentation
Birmingham, UK
Year and Date
2013-05-27
Related Report
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[Presentation] Effects of low-dose human atrial natriuretic peptide for preventing postoperative cardiopulmonary complications in chronic obstructive pulmonary disease patients undergoing lung cancer surgery2012
Author(s)
Takashi Nojiri, Masayoshi Inoue, Hajime Maeda, Yukiyasu Takeuchi, Masato Minami, Noriyoshi Sawabata, Yasushi Shintani, Tomoyuki Nakagiri, Kazuhiro Yamamoto, Meinoshin Okumura
Organizer
20th European Conference on General Thoracic Surgery
Place of Presentation
Essen, Germany
Related Report
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[Presentation] Effects of low-dose human atrial natriuretic peptide for preventing cancer recurrence or metastasis in lung cancer2012
Author(s)
Takashi Nojiri, Hiroshi Hosoda, Takeshi Tokudome, Toru Kimura, Yasushi Shintani, Masayoshi Inoue, Hajime Maeda, Yukiyasu Takeuchi, Masato Minami, Noriyoshi Sawabata, Tomoyuki Nakagiri, Soichiro Funaki, Mikiya Miyazato, Kenji Kangawa, Meinoshin Okumura
Organizer
5th Asia Pacific Lung Cancer Conference
Place of Presentation
Fukuoka, Japan
Related Report
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[Presentation] Effects of low-dose human atrial natriuretic peptide for preventing postoperative cardiopulmonary complications in chronic obstructive pulmonary disease patients undergoing lung cancer surgery.2012
Author(s)
Nojiri T, Inoue M, Maeda H, Takeuchi Y, Minami M, Sawabata N, Shintani Y, Nakagiri T, Yamamoto K, Okumura M.
Organizer
20th European Conference on General Thoracic Surgery (ESTS)
Place of Presentation
Essen, Germany
Related Report
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[Presentation] Effects of low-dose human atrial natriuretic peptide for preventing cancer recurrence or metastasis in lung cancer2012
Author(s)
Nojiri T, Hosoda H, Tokudome T, Kimura T, Shintani Y, Inoue M, Maeda H, Takeuchi Y, Minami M, Sawabata N, Nakagiri T, Funaki S, Miyazato M, Kangawa K, Okumura M.
Organizer
5th Asia Pacific Lung Cancer Conference
Place of Presentation
Fukuoka
Related Report
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[Presentation] Efficacy of low-dose human atrial natriuretic peptide on postoperative cardiopulmonary complications in elderly patients undergoing pulmonary resection for lung cancer2011
Author(s)
Takashi Nojiri, Masayoshi Inoue, Masato Minami, Noriyoshi Sawabata, Yoshihisa Kadota, Yasushi Shintani, Tomoyuki Nakagiri, Kazuhiro Yamamoto, Hajime Maeda, Yukiyasu Takeuchi, Yasunobu Funakoshi, Meinoshin Okumura
Organizer
American Association for Thoracic Surgery 91st Annual Meeting
Place of Presentation
Philadelphia, PA, USA
Related Report
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[Presentation]2011
Author(s)
Takashi Nojiri, Masayoshi Inoue, Masato Minami, Noriyoshi Sawabata, Yoshihisa Kadota, Yasushi Shintani, Tomoyuki Nakagiri, Kazuhiro Yamamoto, Hajime Maeda, Yukiyasu Takeuchi, Yasunobu Funakoshi, Meinoshin Okumura
Organizer
第64回日本胸部外科学会定期学術集会
Place of Presentation
名古屋
Related Report
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[Presentation] Efficacy of low-dose human atrial natriuretic peptide on postoperative cardiopulmonary complications in elderly patients undergoing pulmonary resection for lung cancer.2011
Author(s)
Nojiri T, Inoue M, Minami M, Sawabata N, Kadota Y, Shintani Y, Nakagiri T, Yamamoto K, Maeda H, Takeuchi Y, Funakoshi Y, Okumura M.
Organizer
American Association for Thoracic Surgery 91st Annual Meeting
Place of Presentation
Philadelphia, PA, USA
Related Report
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[Presentation] Efficacy of low-dose human atrial natriuretic peptide on postoperative cardio-pulmonary-renal complications in elderly patients undergoing pulmonary resection for lung cancer.2011
Author(s)
Nojiri T, Inoue M, Minami M, Sawabata N, Kadota Y, Shintani Y, Nakagiri T, Yamamoto K, Maeda H, Takeuchi Y, Funakoshi Y, Okumura M.
Organizer
第64回日本胸部外科学会定期学術集会
Place of Presentation
名古屋
Related Report
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