The identification of molecular targets for glioblastoma using mouse model transplanted transgenic neural stem cell

• Project/Area Number: 23791588
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cerebral neurosurgery
• Research Institution: Kanazawa University
• Principal Investigator: TAMASE Akira 金沢大学, 医学系, 協力研究員 (10595458)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: グリオーマ / 幹細胞 / マウスモデル / 標的分子 / マイクロアレイ / 分子標的

Research Abstract

We explored the genes which overexpressed in glioma stem-like cells using the mouse glioma model transplanted transgenic neural stem cells. Glioma stem-like cells were labeled by Green Fluorescent Protein (GFP). The gene expression profiles of which cells are GFP positive or are GFP negative havebeen obtained by microarray data, respectively. Fifty candidate genes were picked up. Among them, two genes have been identified as promising genes.

Research Products

• [Journal Article] Nucleostemin in injury-induced liver regeneration. (2012)
  • Author(s): Shugo. H
  • Journal Title: Stem cells Dev. Volume: 21 Issue: 16 Pages: 3044-3054
  • DOI: 10.1089/scd.2011.0725
  • Peer Reviewed
• [Presentation] マウスグリオーマモデルを用いた新たな治療標的分子の探索 (2012)
  • Author(s): 玉瀬玲、中田光俊、平尾敦、〓田潤一郎
  • Organizer: 第13回日本分子脳神経外科学会
  • Place of Presentation: 熊本市国際交流会館(熊本)
• [Presentation] マウスグリオーマモデルを用いた新たな治療標的分子の探索 (2012)
  • Author(s): 玉瀬玲、中田光俊、平尾敦、濵田潤一郎
  • Organizer: 第13回日本分子脳神経外科学会
  • Place of Presentation: 熊本市国際交流会館（熊本）
• [Remarks] 金沢大学脳神経外科
  • URL: http://neurosurgery.w3.kanazawa-u.ac.jp/
• [Remarks]
  • URL: http://neurosurgery.w3.kanazawa-u.ac.jp/