| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
It has been reported that embolization coils coated with some kinds of proteins, such as growth factors, are effective in the prevention of recanalization in embolized aneurysms. These coils are, however, difficult to be sterilized and unstable, therefore, not assumed to be approved easily. The aim of this project is integration of a treatment with a device and regenerative medicine via the development of a novel device for a therapy of brain aneurysms which combined conventional embolization coils and low-molecular-weight drugs, following a succeeded example, drug eluting stent. In this project, statins, which were drugs for the treatment of hypercholesterolemia, were selected as low-molecular-weight drugs. Formation of phospholipid layers onto coil surfaces, conjugation of stains into these layers and continuous release of statins from the conjugated layer were tried. The feasibility of analyses using a fluorescent microscope, surface plasmon resonance, surface plasmon field-enhanced fluorescent and cell culture were also assessed. Beneficial information for conjugation and continuous release of statins from the phospholipid layer for was obtained from these assessments and coils containing phospholipid layer conjugated with statins were composed. These coils were expected to have a high potential as embolization coils for aneurysms.
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