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In vivo MR imaging of bone marrow cells in GBM

Research Project

Project/Area Number 23791595
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionOsaka University

Principal Investigator

KINOSHITA Manabu  大阪大学, 医学系研究科, 助教 (40448064)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords膠芽腫 / MRI / 造血幹細胞 / 分子イメージング
Research Abstract

We have developed MagA, which is an MR reporter gene, overexpressing transgenic mouse, and pursued the possibility of tracking bone marrow derived cells in the course of glioblastoma development by MRI. We were able to confirm that bone marrow cells from MagA transgenic mouse accumulate more iron than wild type mouse and that those cells showed hypo-intense signals under MRI observation.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (41 results)

All 2013 2012 2011 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (22 results) Remarks (3 results)

  • [Journal Article] Radiation-induced anaplastic ependymoma with a remarkable clinical response to temozolomide: a case report.2013

    • Author(s)
      Khoo HM, Kishima H, Kinoshita M, Goto Y, Kagawa N, Hashimoto N, Maruno M, Yoshimine T.
    • Journal Title

      Br J Neurosurg

      Volume: 27(2) Issue: 2 Pages: 259-61

    • DOI

      10.3109/02688697.2012.741740

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Training to acquire psychomotor skills for endoscopic endonasal surgery using a personal webcam trainer.2013

    • Author(s)
      Hirayama R, Fujimoto Y, Umegaki M, Kagawa N, Kinoshita M, Hashimoto N, Yoshimine T.
    • Journal Title

      J Neurosurg.

      Volume: 118(5) Issue: 5 Pages: 1120-6

    • DOI

      10.3171/2012.12.jns12908

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of cerebral aneurysm in patients with acromegaly.2012

    • Author(s)
      Oshino Satoru
    • Journal Title

      Pituitary

      Volume: - Issue: 2 Pages: 195-201

    • DOI

      10.1007/s11102-012-0404-x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel PET index, 18F-FDG-11C-methionine uptake decoupling score, reflects glioma cell infiltration.2012

    • Author(s)
      Kinoshita M
    • Journal Title

      J Nucl Med

      Volume: 53(11) Issue: 11 Pages: 1701-1708

    • DOI

      10.2967/jnumed.112.104992

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] iological characteristics of growth hormone-producing pituitary adenomas are different according to responsiveness tothyrotropin-releasing hormone.2012

    • Author(s)
      Arita H
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 97(8) Issue: 8 Pages: 2741-2747

    • DOI

      10.1210/jc.2012-1125

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Use of (11)C-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma2012

    • Author(s)
      Yasuyoshi Chiba
    • Journal Title

      Journal of Neurosurgery

      Volume: (in press) Issue: 4 Pages: 835-842

    • DOI

      10.3171/2011.12.jns111255

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics of meningiomas assessed by (11)C-methionine and (18)F-fluorodeoxyglucose positron-emission tomography2012

    • Author(s)
      Arita H
    • Journal Title

      J Neurooncol

      Volume: 107(2) Issue: 2 Pages: 379-386

    • DOI

      10.1007/s11060-011-0759-2

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cardiac-cycle related volume change in unruptured cerebral aneurysms : a detailed volume quantification study using 4DCTA2012

    • Author(s)
      Kuroda J, Kinoshita M, Tanaka H, Nishida T, Nakamura H, Watanabe Y, Tomiyama N, Fujinaka T, Yoshimine T
    • Journal Title

      Stroke

      Volume: 43(1) Issue: 1 Pages: 61-66

    • DOI

      10.1161/strokeaha.111.626846

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] (11) C-methiomne uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma : A stereotactic imaee-histological analysis2012

    • Author(s)
      Arita H
    • Journal Title

      Cancer

      Volume: 118(6) Issue: 6 Pages: 1619-1627

    • DOI

      10.1002/cncr.26445

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Imaging (18)F-fluorodeoxy glucose/(11)C-methionine uptake decoupling for identification of tumor cell infiltration in peritumoral brain edema2012

    • Author(s)
      Kinoshita M
    • Journal Title

      J Neurooncol

      Volume: 106(2) Issue: 2 Pages: 417-425

    • DOI

      10.1007/s11060-011-0688-0

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Slower growth of skull base meningiomas compared with non-skull base meningiomas based on volumetric and biological studies2011

    • Author(s)
      Naoya Hashimoto
    • Journal Title

      Journal of Neurosurgery

      Volume: 116(3) Issue: 3 Pages: 574-80

    • DOI

      10.3171/2011.11.jns11999

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hepatitis B virus reactivation associated with temozolomide for malignant glioma : a case report and recommendation for prophylaxis2011

    • Author(s)
      Yasunori Fujimoto
    • Journal Title

      International Journal of Clinical Oncology

      Volume: (in press) Issue: 3 Pages: 290-293

    • DOI

      10.1007/s10147-011-0294-3

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Significance of tumor volume related to peritumoral edema in intracranial meningioma treated with extreme hypofractionated stereotactic radiation therapy in three to five fractions2011

    • Author(s)
      Masashi Morimoto
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 41(5) Issue: 5 Pages: 609-616

    • DOI

      10.1093/jjco/hyr022

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantification of cerebral artery motion during the cardiac cycle2011

    • Author(s)
      Nishida T, Kinoshita M, Tanaka H, Fujinaka T, Yoshimine T
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: 32(11) Issue: 11 Pages: E206-E208

    • DOI

      10.3174/ajnr.a2354

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hemifacial spasm caused by intra-axial brainstem cavernous angioma with venous angiomas.2011

    • Author(s)
      Hideyuki Arita
    • Journal Title

      British Journal of Neurosurgery

      Volume: -

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] CD166/Activated leukocyte cell adhesion molecule is expressed on glioblastoma progenitor cells and involved in the regulation of tumor cell invasion2011

    • Author(s)
      Noriyuki Kijima
    • Journal Title

      Neuro-Oncology

      Volume: (in press) Issue: 10 Pages: 1254-1264

    • DOI

      10.1093/neuonc/nor202

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 4D 造影 CT に 機能性微小下垂体腺腫の局在診断と造影効果の動態解析2013

    • Author(s)
      木下 学
    • Organizer
      第23回日本間脳下垂体腫瘍学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2013-03-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Affibody-SPIO に MR 分 イメ グ2012

    • Author(s)
      木下 学
    • Organizer
      第30回日本脳腫瘍学会学術集会
    • Place of Presentation
      広島
    • Year and Date
      2012-11-25
    • Related Report
      2012 Final Research Report
  • [Presentation] DIFFERENTIATION BETWEEN HIGH- AND LOW-GRADE MR NON-ENHANCING GLIOMAS USING PET-COMPARISON OF 11C-METHIONINE FDG PET, AND 11C-METHIONINE/FDG DECOUPLING SCORE2012

    • Author(s)
      Kinoshita Manabu
    • Organizer
      17th Annual Scientific Meeting of Society for NeuroOncology
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2012-11-17
    • Related Report
      2012 Final Research Report
  • [Presentation] FDG/11C-methionine PET非同期度に 非造影グリ のグ ド判別2012

    • Author(s)
      木下 学
    • Organizer
      第71回日本脳神経外科学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2012-10-19
    • Related Report
      2012 Final Research Report
  • [Presentation] ルチモダリ ナビゲ ガイド下定位的組織採取のための解析ソフ ア開発2012

    • Author(s)
      木下 学
    • Organizer
      第64回日本脳神経外科学会近畿支部学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 11C-methionine PET parametric response map, but not conventional MRI, corresponds to treatment response of WT1 immunotherapy for recurrent malignant glioma.2012

    • Author(s)
      Kinoshita Manabu
    • Organizer
      International Society for Magnetic Resonance in Medicine (ISMRM) 20th Scientific Meeting
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2012-05-05
    • Related Report
      2012 Final Research Report
  • [Presentation] IgG4関連下垂体炎と下垂体 標的とし い頭蓋 IgG4関連疾患の違い2012

    • Author(s)
      木下 学
    • Organizer
      第22回日本間脳下垂体腫瘍学会
    • Place of Presentation
      東京
    • Year and Date
      2012-02-24
    • Related Report
      2012 Final Research Report
  • [Presentation] IgG4 関連下垂体炎における下垂体炎組織と周辺炎症性硬膜組織の違い2012

    • Author(s)
      木下 学
    • Organizer
      第22回日本間脳下垂体腫瘍学会
    • Place of Presentation
      東京ステーションコンファレンス(東京)
    • Related Report
      2011 Research-status Report
  • [Presentation] 非造影グリ 病変 はFDG/11C-methionine PET 非同期度 腫瘍細胞密度 反映する2011

    • Author(s)
      木下 学
    • Organizer
      第29回日本脳腫瘍学会学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-11-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Voxel-wise analysis of FDG and 11C-methionine PET can accurately detect glioma infiltration in the MR T2-hyper-intense area2011

    • Author(s)
      Kinoshita Manabu
    • Organizer
      16th Annual Scientific Meeting of Society for NeuroOncology.
    • Place of Presentation
      California, USA
    • Year and Date
      2011-11-18
    • Related Report
      2012 Final Research Report
  • [Presentation] FDG/11C-methionine PET非同期度解析はグリ の脳組織浸潤度の定 的評価 可能にする2011

    • Author(s)
      木下 学
    • Organizer
      第70回日本脳神経外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-10-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Segmentation of tumor infiltrative and vasogenic edema in brain tumors using voxel-wise analysis of 11C-methinonine and FDG PET and its comparison with diffusion tensor imaging2011

    • Author(s)
      Kinoshita Manabu
    • Organizer
      International Society for Magnetic Resonance in Medicine (ISMRM) 19th Scientific Meeting
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2011-05-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Segmentation of tumor infiltrative and vasogenic edema in brain tumors using voxel-wise analysis of 11C-methinonine and FDG PET and its comparison with diffusion tensor imaging.2011

    • Author(s)
      Manabu Kinoshita
    • Organizer
      International Society for Magnetic Resonance in Medicine (ISMRM) 19th Scientific Meeting
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2011 Research-status Report
  • [Presentation] FDG/11C-methionine PET非同期度解析はグリオーマの脳組織浸潤度の定量的評価を可能にする2011

    • Author(s)
      木下 学
    • Organizer
      第70回日本脳神経外科学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Voxel-wise analysis of FDG and 11C-methionine PET can accurately detect glioma infiltration in the MR T2-hyper-intense area.2011

    • Author(s)
      Manabu Kinoshita
    • Organizer
      The 16th Annual Scientific Meeting of the Society for Neuro-Oncology
    • Place of Presentation
      California, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] 非造影グリオーマ病変ではFDG/11C-methionine PET 非同期度が腫瘍細胞密度を反映する2011

    • Author(s)
      木下 学
    • Organizer
      第29回日本脳腫瘍学会学術集会
    • Place of Presentation
      水明館(岐阜県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 11C-methionine PET parametric response map, but not conventional MRI, corresponds to treatment response of WT1 immunotherapy for recurrent malignant glioma.

    • Author(s)
      Kinoshita Manabu
    • Organizer
      International Society for Magnetic Resonance in Medicine (ISMRM) 20th Scientific Meeting.
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2012 Annual Research Report
  • [Presentation] マルチモダリティナビゲーションガイド下定位的組織採取のための解析ソフトウェア開発

    • Author(s)
      木下 学
    • Organizer
      第64回日本脳神経外科学会近畿支部学術集会
    • Place of Presentation
      大阪府・千里ライフサイエンスセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] FDG/11C-methionine PET非同期度による非造影グリオーマのグレード判別

    • Author(s)
      木下 学
    • Organizer
      第71回日本脳神経外科学会学術総会
    • Place of Presentation
      大阪府・大阪国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] DIFFERENTIATION BETWEEN HIGH- AND LOW-GRADE MR NON-ENHANCING GLIOMAS USING PET-COMPARISON OF 11C-METHIONINE, FDG PET, AND 11C-METHIONINE/FDG DECOUPLING SCORE

    • Author(s)
      Kinoshita Manabu
    • Organizer
      The 17th Annual Scientific Meeting of the Society for Neuro-Oncology
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Affibody-SPIO によるMR 分子イメージング

    • Author(s)
      木下 学
    • Organizer
      第30回日本脳腫瘍学会
    • Place of Presentation
      広島県・グランドプリンスホテル広島
    • Related Report
      2012 Annual Research Report
  • [Presentation] 4D造影CTによる機能性微小下垂体腺腫の局在診断と造影効果の動態解析

    • Author(s)
      木下 学
    • Organizer
      第23回日本間脳下垂体腫瘍学会
    • Place of Presentation
      鹿児島県・かごしま県民交流センター
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.manabukinoshita.com

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.dma.jim.osaka-u.ac.jp/kg-portal/aspi/RX0011D.asp?UNO=21259&page=159

    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.manabukinoshita.com/Manabu_Kinoshita/mu_xiaxue_ri_ben_yu.html

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2025-11-18  

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