Adult Olfactory Sphere Cells are aSource of Oligodendrocyte and Schwann Cell Progenitors

• Project/Area Number: 23791596
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cerebral neurosurgery
• Research Institution: Osaka University
• Principal Investigator: OHNISHI Yu-ichiro 大阪大学, 医学部附属病院, 医員 (00533811)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: オルファクトリースフィア / オリゴデンドロサイト / 嗅粘膜 / ニューロン / 幹細胞 / 分化

Research Abstract

We show that both HBCs and OSs express OPC markers, and that OS cells differentiate into oligodendrocytes and Schwann cells.

Research Products

• [Journal Article] Entrapment of the fifth lumbar spinal nerve by advanced osteophytic changes of the lumbosacral zygapophyseal joint: a case report (2012)
  • Author(s): Ohnishi Y, Yuguchi T, Iwatsuki K, Yoshimine T
  • Journal Title: Asian Spine J Volume: 6(4) Pages: 291-3
• [Journal Article] Transient total mesencephalic locked-in syndrome after bilateral ptosis due to basilar artery thrombosis (2012)
  • Author(s): Fujimoto Y, Ohnishi Y, Wakayama A, Yoshimine T
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 21(8)
• [Journal Article] Disuse muscle atrophy exacerbates motor neuronal degeneration caudal to the site of spinal cord injury (2012)
  • Author(s): Ohnishi Y, Iwatsuki K, Shinzawa K, Nakai Y, Ishihara M, Yoshimine T
  • Journal Title: Neuroreport. Volume: 23(3) Pages: 157-61
• [Journal Article] Disuse muscle atrophy exacerbates motor neuronal degeneration caudal to the site of spinal cord injury (2012)
  • Author(s): Yu-ichiro Ohnishi
  • Journal Title: Neuroreport Volume: 23 Pages: 157-161
  • Peer Reviewed
• [Journal Article] Entrapment of the Fifth Lumbar Spinal Nerve by Advanced Osteophytic Changes of the Lumbosacral Zygapophyseal Joint (2012)
  • Author(s): Yu-ichiro Ohnishi
  • Journal Title: Asian Spine Journal Volume: 6 Pages: 291-293
  • Peer Reviewed
• [Journal Article] A new three-dimensional axonal outgrowth assay for central nervous system regeneration (2011)
  • Author(s): Ishihara M, Mochizuki-Oda N, Iwatsuki K, Kishima H, Iwamoto Y, Ohnishi Y,Umegaki M, Yoshimine T
  • Journal Title: J Neurosci Methods Volume: 198(2) Pages: 181-6
• [Journal Article] Percutaneous diode laser irradiation for lumbar discogenic pain: a clinical study (2011)
  • Author(s): Iwatsuki K, Yoshimine T, Umegaki M, Yoshimura K, Ohnishi Y, Ishihara M, Moriwaki T.
  • Journal Title: Photomed Laser Surg Volume: 29(7) Pages: 459-63
• [Journal Article] Bow hunter's stroke due to instability at the uncovertebral C3/4 joint (2011)
  • Author(s): Yoshimura K, Iwatsuki K, Ishihara M, Onishi Y, Umegaki M, Yoshimine T
  • Journal Title: Eur Spine J Volume: 20 Suppl 2
• [Journal Article] Histopathological study of spinal meningioma originating from the arachnoid villi (2011)
  • Author(s): Ohnishi Y, Iwatsuki K, Morii E, Kobayashi M, Hori Y, Moriwaki T, Ishihara M,Yoshimura K, Umegaki M, Yoshimine T
  • Journal Title: Brain Tumor Pathol Volume: 28(1) Pages: 77-81
• [Presentation] オルファクトリースフィア(OS)細胞のグリア細胞とニューロンへの分化の検討 (2013)
  • Author(s): 大西諭一郎
  • Organizer: 日本再生医療学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2013-03-22
• [Presentation] 慢性期脊髄損傷に対する嗅粘膜移植術 (2012)
  • Author(s): 大西諭一郎
  • Organizer: 日本再生医療学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2012-06-12
• [Book] 脊髄損傷慢性期に対する嗅粘膜移植法 (2011)
  • Author(s): 大西諭一郎、岩月幸一、吉峰俊樹
  • Publisher: 中外医学社
• [Patent(Industrial Property Rights)] オルファクトリースフィア細胞の単離方法、該オルファクトリースフィア細胞を用いた脱髄疾患治療剤及び末梢神経軸索再生増強剤の製造方法 (2012)
  • Inventor(s): 大西諭一郎
  • Industrial Property Rights Holder: 大西諭一郎
  • Filing Date: 2012-09-20
• [Patent(Industrial Property Rights)] オルファクトリースフィア細胞の単離方法、該オルファクトリースフィア細胞を用いた脱髄疾患治療剤及び末梢神経軸索再生増強剤の製造方法 (2012)
  • Inventor(s): 大西諭一郎
  • Industrial Property Rights Holder: 大西諭一郎
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-09-20