Development of the in vivo imaging technology in WT1 peptide vaccination for malignant brain tumor.
| Project/Area Number |
23791597
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
CHIBA Yasuyoshi 大阪大学, 医学(系)研究科(研究院), 助教 (90533795)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 悪性グリオーマ / WT1 / 免疫療法 / 癌ワクチン / 腫瘍浸潤リンパ球 / in vivoイメージング / メチオニンPET / GFPマウス / peptide vaccination / immunotherapy / methionine PET / parametric response map / 悪性神経膠腫 / Wilms’ tumor 1 (WT1) / ペプチドワクチン / がん免疫療法 |
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| Research Abstract |
We developed the suitable imaging evaluation method for WT1 peptide vaccination for recurrent malignant gliomas. Usually, it is although the treatment evaluation for a brain tumor is performed by MRI in many cases, it became clear that the evaluation by MRI does not reflect survival time and that the accumulation value and volume evaluation using the methionine-PET reflected survival time comparatively by this research. The appraisal method which reflected survival time most was an method using parametric response map (PRM) which united the methionine PET before and after WT1 peptide vaccination, and expressed change of the accumulation value to each voxel (1 mm3).
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Use of (11)C-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma2012
Author(s)
Chiba Y, Kinoshita M, Okita Y, Tsuboi A, Isohashi K, Kagawa N, Fujimoto Y, Oji Y, Oka Y, Shimosegawa E, Morita S, Hatazawa J, Sugiyama H, Hashimoto N, Yoshimine T.
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Journal Title
J Neurosurg
Volume: 116(4)
Pages: 835-842
Related Report
Peer Reviewed
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[Journal Article] A survey of disclosure of diagnosis to patients with glioma in Japan2011
Author(s)
Yamamoto F, Hashimoto N, Kagawa N, Okita Y, Chiba Y, Kijima N, Kinoshita M, Yoshizu K, Fujimoto Y, Hirai K, Yoshimine T
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Journal Title
Int J Clin Oncol
Volume: 16(3)
Issue: 3
Pages: 230-237
DOI
NAID
Related Report
Peer Reviewed
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