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Development of the in vivo imaging technology in WT1 peptide vaccination for malignant brain tumor.

Research Project

Project/Area Number 23791597
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionOsaka University

Principal Investigator

CHIBA Yasuyoshi  大阪大学, 医学(系)研究科(研究院), 助教 (90533795)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords悪性グリオーマ / WT1 / 免疫療法 / 癌ワクチン / 腫瘍浸潤リンパ球 / in vivoイメージング / メチオニンPET / GFPマウス / peptide vaccination / immunotherapy / methionine PET / parametric response map / 悪性神経膠腫 / Wilms’ tumor 1 (WT1) / ペプチドワクチン / がん免疫療法
Research Abstract

We developed the suitable imaging evaluation method for WT1 peptide vaccination for recurrent malignant gliomas. Usually, it is although the treatment evaluation for a brain tumor is performed by MRI in many cases, it became clear that the evaluation by MRI does not reflect survival time and that the accumulation value and volume evaluation using the methionine-PET reflected survival time comparatively by this research. The appraisal method which reflected survival time most was an method using parametric response map (PRM) which united the methionine PET before and after WT1 peptide vaccination, and expressed change of the accumulation value to each voxel (1 mm3).

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (28 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (25 results)

  • [Journal Article] Use of (11)C-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma2012

    • Author(s)
      Chiba Y, Kinoshita M, Okita Y, Tsuboi A, Isohashi K, Kagawa N, Fujimoto Y, Oji Y, Oka Y, Shimosegawa E, Morita S, Hatazawa J, Sugiyama H, Hashimoto N, Yoshimine T.
    • Journal Title

      J Neurosurg

      Volume: 116(4) Pages: 835-842

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Use of (11)C-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma2012

    • Author(s)
      Yasuyoshi Chiba
    • Journal Title

      Journal of Neurosurgery

      Volume: (in press) Issue: 4 Pages: 835-842

    • DOI

      10.3171/2011.12.jns111255

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A survey of disclosure of diagnosis to patients with glioma in Japan2011

    • Author(s)
      Yamamoto F, Hashimoto N, Kagawa N, Okita Y, Chiba Y, Kijima N, Kinoshita M, Yoshizu K, Fujimoto Y, Hirai K, Yoshimine T
    • Journal Title

      Int J Clin Oncol

      Volume: 16(3) Issue: 3 Pages: 230-237

    • DOI

      10.1007/s10147-010-0152-8

    • NAID

      10029526965

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] WT1ペプチドワクチン療法におけるMRIを用いた画像評価法の検討2013

    • Author(s)
      千葉泰良
    • Organizer
      第31回日本脳腫瘍学会学術集会
    • Place of Presentation
      宮崎
    • Year and Date
      2013-12-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Immune escape in human malignant gliomas after WT1 peptide vaccination2013

    • Author(s)
      Yasuyoshi Chiba
    • Organizer
      SNO 4th Quadrennial Meeting of the World Federation of Neuro-Oncology
    • Place of Presentation
      San Francisco , USA
    • Year and Date
      2013-11-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 再発悪性グリオーマに対するWT1ペプチドワクチン療法後の免疫逃避機構2013

    • Author(s)
      千葉泰良
    • Organizer
      第72回日本脳神経外科学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 再発悪性グリオーマに対するWT1ペプチドワクチン療法後の腫瘍浸潤リンパ球と免疫逃避2013

    • Author(s)
      千葉泰良
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Tumor-infiltrating lymphocytes and immune escape in patients with recurrent maligtant glioma after WT1 Peptide Vaccination2013

    • Author(s)
      Yasuyoshi Chiba
    • Organizer
      The 10th Annual Meeting of the Asian Society for Neuro-oncology (ASNO)
    • Place of Presentation
      Mumbai, India
    • Year and Date
      2013-03-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Tumor-infiltrating lymphocytes and immune escape in human recurrent malignan t glioma after WT1 peptide vaccination2013

    • Author(s)
      Yasuyoshi Chiba, Naoya Hashimoto, Akihiro Tsuboi, Yoshihiro Oka, Naoki Kagawa, Yuusuke Oji, Toshiki Yoshimine, Haruo Sugiyama
    • Organizer
      第72回日本癌学会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 再発悪性グリオーマに対するWT1ペプチドワクチン療法後の免疫逃避機構2013

    • Author(s)
      千葉 泰良, 橋本 直哉, 坪井 昭博, 香川 尚己, 平山 龍一,尾路 祐介, 岡 芳弘, 杉山 治夫 吉峰 俊樹
    • Organizer
      第72回日本脳神経外科学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Immune escape in human malignant gliomas after WT1 peptide vaccination2013

    • Author(s)
      Yasuyoshi Chiba, Naoya Hashimoto, Naoki Kagawa, Ryuichi Hirayama, Akihiro Tsuboi, Yuusuke Oji, Yoshihiro Oka, Haruo Sugiyama, Toshiki Yoshimine,
    • Organizer
      Society for Neurooncology
    • Place of Presentation
      San Fransisco(米国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] グリオーマにおける1p19q共欠失とα-internexin発現との関連2012

    • Author(s)
      千葉泰良
    • Organizer
      第30回日本脳腫瘍学会学術集会
    • Place of Presentation
      広島
    • Year and Date
      2012-11-26
    • Related Report
      2013 Final Research Report
  • [Presentation] Tumor-infiltrating lymphocytes and immune escape in patients with maligtant glioma receiving WT1 Peptide Vaccination2012

    • Author(s)
      Yasuyoshi Chiba
    • Organizer
      The 6th International Conference on WT1 in Human Neoplasia
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2012-11-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Tumor-infiltrating lymphocytes and immune escape in patients with maligtant glioma receiving WT1 Peptide Vaccination2012

    • Author(s)
      Yasuyoshi Chiba
    • Organizer
      SNO 17th Annual Scientific Meeting
    • Place of Presentation
      Washington DC , USA
    • Year and Date
      2012-11-17
    • Related Report
      2013 Final Research Report
  • [Presentation] WT1ワクチン療法における画像と免疫学的指標を用いた治療効果評価2012

    • Author(s)
      千葉泰良
    • Organizer
      第71回日本脳神経外科学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2012-10-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 11 C-methionine PETを用いたparametric response mapによるWT1療法の効果判定2011

    • Author(s)
      千葉泰良
    • Organizer
      第29回日本脳腫瘍学会学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-11-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Voxel-wise functional 11C-methionine positron emission tomography analysis but not conventional MRI corresponds to treatment response of WT1 immunotherapy for recurrent high-grade glioma2011

    • Author(s)
      Yasuyoshi Chiba
    • Organizer
      16th Annual Scientific Meeting of Society for NeuroOncology
    • Place of Presentation
      California, USA
    • Year and Date
      2011-11-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 悪性グリオーマに対するWT1ペプチドワクチン療法後の浸潤リンパ球と免疫逃避2011

    • Author(s)
      千葉泰良
    • Organizer
      第15回日本がん免疫学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2011-06-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 再発GBMに対するWT1ペプチド療法におけるHLA class発現と予後との関連2011

    • Author(s)
      千葉泰良
    • Organizer
      第69回日本脳腫瘍病理学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 再発GBMに対するWT1ワクチン療法におけるHLA class1発現と予後との関連2011

    • Author(s)
      千葉 泰良
    • Organizer
      第29回日本脳腫瘍病理学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 悪性グリオーマに対するWT1ペプチドワクチン療法後の浸潤リンパ球と免疫逃避2011

    • Author(s)
      千葉 泰良
    • Organizer
      日本癌免疫学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Research-status Report
  • [Presentation] Voxel-wise functional 11C-methionine positron emission tomography analysis but not conventional MRI corresponds to treatment response of WT1 immunotherapy for recurrent high-grade glioma.2011

    • Author(s)
      Chiba Y
    • Organizer
      16th Society of Neuro-Oncology
    • Place of Presentation
      Garden Grove, CA USA
    • Related Report
      2011 Research-status Report
  • [Presentation] 11C-methionine PETを用いたparametric response mapによるWT1療法の効果判定2011

    • Author(s)
      千葉 泰良
    • Organizer
      日本脳腫瘍学会
    • Place of Presentation
      下呂温泉
    • Related Report
      2011 Research-status Report
  • [Presentation] WT1ペプチドワクチン療法におけるMRIを用いた画像評価法の検討

    • Author(s)
      千葉泰良、橋本直哉、坪井昭博、香川尚己、平山龍一、尾路祐介、岡芳弘、杉山治夫、吉峰俊樹
    • Organizer
      第31回日本脳腫瘍学会学術集会
    • Place of Presentation
      フェニックス・シーガイア・リゾート(宮崎)
    • Related Report
      2013 Annual Research Report
  • [Presentation] WT1ワクチン療法における画像と免疫学的指標を用いた治療効果評価

    • Author(s)
      千葉 泰良
    • Organizer
      第70回日本脳神経外科学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] TUMOR-INFILTRATING LYMPHOCYTES AND IMMUNE ESCAPE IN HUMAN MALIGNANT GLIOMAS AFTER WT1 VACCINATION

    • Author(s)
      Yasuyoshi Chiba
    • Organizer
      The 17th Annual Scientific Meeting of the Society for Neuro-Oncology
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Tumor-infiltrating lymphocytes and immune escape in patients with malignant glioma receiving WT1 peptide vaccination

    • Author(s)
      千葉 泰良
    • Organizer
      第6回国際WT1会議
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] TUMOR-INFILTRATING LYMPHOCYTES AND IMMUNE ESCAPE IN PATIENTS WITH RECURRENT MALIGTANT GLIOMA AFTER WT1 PIPTIDE  VACCINATION

    • Author(s)
      Yasuyoshi Chiba
    • Organizer
      The 10th Annual Meeting of the Asian Society for Neuro-oncology (ASNO)
    • Place of Presentation
      Mumbai, India
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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