The effects of deep brain stimulation on sensory function in Parkinson's disease.
| Project/Area Number |
23791598
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
MARUO Tomoyuki 大阪大学, 医学(系)研究科(研究院), 特任助教 (90533810)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | パ－キンソン病 / 視床下核刺激 / 脳血流 / パーキンソン病 / 脳深部刺激術 / 神経変性疾患 / 感覚認知 / 脳血流代謝 / 脳深部刺激 |
|---|
| Research Abstract |
Parkinson's disease is the most common of the neurodegenerative disease which has the motor symptoms. In addition to motor symptoms, sensory disturbances are part of the clinical picture of Parkinson's disease. Little is known about the effects of deep brain stimulation (DBS) on sensory symptoms and the mechanisms by which DBS alleviates sensory symptoms in Parkinson's disease. The aim of our study was to evaluate the effects of DBS on cerebral blood flow (CBF). We used Parkinson's model rats created by the nigra injection of 6-hydroxydopamine (6-OHDA) that enabled us to investigate CBF using laser speckle flowmetry (LSF), thus allowing the continuous imaging of the spatiotemporal dynamics of CBF changes in rats. We observed that CBF in primary sensorimotor area had increased temporarily during STN-DBS. LSF is useful to assess the changes in CBF that are related to neural activity, and the mechanisms of deep brain stimulation, with high temporal and spatial resolution.
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Report
(4 results)
Research Products
(100 results)
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[Journal Article] Low-frequency subthalamic nucleus stimulation in Parkinson's disease: a randomized clinical trial.2014
Author(s)
Khoo HM, Kishima H, Hosomi K, Maruo T, Tani N, Oshino S, Shimokawa T, Yokoe M, Mochizuki H, Saitoh Y, Yoshimine T.
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Journal Title
Mov Disord.
Volume: 29(2)
Issue: 2
Pages: 2270-4
DOI
Related Report
Peer Reviewed
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[Journal Article] Validity, reliability and assessment sensitivity of the Japanese version of the Short-Form McGill Pain Questionnaire 2 in Japanese patients with neuropathic and non-neuropathic pain2014
Author(s)
Maruo T, Nakae A, Maeda L, Shi K, Takahashi K, Morris S, Hosomi K, Kanatani H, Matsuzaki T, Saitoh Y
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Journal Title
Pain Med.
Volume: in Press
Related Report
Peer Reviewed
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[Journal Article] Which is the Most Appropriate Disconnection Surgery for Refractory Epilepsy in Childhood?2013
Author(s)
Kishima H, Oshoni S, Tani N, Maruo T, Morris S, Khoo HM, Yanagisawa T, Shimono K, Okinaga T, Hirata M, Kato A, Yoshimine T.
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Journal Title
Neurologia medico-chirurgica
Volume: 53
Issue: 11
Pages: 814-820
DOI
NAID
ISSN
0470-8105, 1349-8029
Related Report
Peer Reviewed
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[Presentation] Repetitive Transcranial Magnetic Stimulation over Primary Leg Motor Area in Parkinson's Disease
Author(s)
Tomoyuki Maruo,Koichi Hosomi,Toshio Shimokawa,Haruhiko Kishima,Satoru Oshino,Shayne Morris,Yu Kageyama,Masaru Yokoe,Toshiki Yoshimine,Youichi Saitoh.
Organizer
15th World Congress of Neurosurgery (WFNS2013)
Place of Presentation
Seoul,Korea
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