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Investigation of biological effects of IDH gene mutation in malignant glioma

Research Project

Project/Area Number 23791614
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionKyorin University

Principal Investigator

TANAKA Masaki  杏林大学, 医学部, 助教 (80531491)

Research Collaborator NAGANE Motoo  杏林大学, 医学部, 教授 (60327468)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords神経膠腫 / IDH1 / 遺伝子異常 / 治療感受性 / 造腫瘍性
Research Abstract

We investigated biological effects of glioma-related genetic alteration, IDH1 gene mutation, in human glioma cells. The IDH1R132H gene was introduced into highly transformed glioblastoma cells by transfection, and the cells overexpressing IDH1R132H were selected by G418 treatment. These cells did not exhibit significant changes in expression of tumor-, apoptosis-, or cell cycle-related genes, but were rather sensitive to CDDP treatment. Xenografts in athymic mice derived from these cells grew slower than parental cells. These results suggested that IDH1 mutation which is a hallmark of representative genetic alterations in lower grade glioma might bestow negative impact on aggressive behavior of higher grade gliomas.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (27 results)

All 2014 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (19 results) (of which Invited: 2 results) Book (2 results) Remarks (1 results)

  • [Journal Article] C viral inclusions in progressive multifocal leukoencephalopathy: Scaffolding promyelocytic leukemia nuclear bodies grow with cell cycle transition through an S-to-G2-like state in enlarging oligodendrocyte nuclei2014

    • Author(s)
      Shishido-Hara Y, Yazawa T, Nagane M, Higuchi K, Abe-Suzuki S, Kurata M, Kitagawa M, Kamma H, Uchihara T
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 73 Issue: 5 Pages: 442-453

    • DOI

      10.1097/nen.0000000000000066

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictive value of mean apparent diffusion coefficient value for responsiveness of temozolomide-refractory malignant glioma to bevacizumab.2013

    • Author(s)
      Nagane M, et al.
    • Journal Title

      Int J Clin Oncol

      Volume: 19 Issue: 1 Pages: 16-23

    • DOI

      10.1007/s10147-013-0517-x

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combination treatment with the anti-EGFR monoclonal antibody, nimotuzumab, and temozolomide causes synergistic growth suppression of mutant EGFR expressing glioma xenografts.2013

    • Author(s)
      Nagane M, Nitta Y, Shimizu S, Shishido-Hara Y, Shiokawa Y
    • Journal Title

      Proceedings of 104th Annual Meeting of the American Association for Cancer Research

      Volume: 54

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multidrug immunochemotherapy (R-MPV-A) for newly diagnosed and recurrent primary central nervous system lymphomas2013

    • Author(s)
      Nagane M, Kobayashi K, Takayama N, Shiokawa S
    • Journal Title

      Neuro-Oncology

      Volume: 15 Supplement 3

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictive value of mean apparent diffusion co-efficient value for responsiveness of temozolomide-refractory malignant glioma to bevacizumab2011

    • Author(s)
      Nagane M, Kobayashi K, Tanaka M, Tsuchiya K, Shiokawa Y
    • Journal Title

      J Clin Oncol

      Volume: 29: suppl

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 悪性脳腫瘍治療の現状と展望2013

    • Author(s)
      永根基雄
    • Organizer
      第8回岐阜脳腫瘍研究会
    • Place of Presentation
      岐阜市,岐阜県
    • Year and Date
      2013-11-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Gliomaの遺伝子異常と治療成績2013

    • Author(s)
      永根基雄
    • Organizer
      第31回日本脳腫瘍病理学会
    • Place of Presentation
      東京
    • Year and Date
      2013-05-24
    • Related Report
      2013 Final Research Report
  • [Presentation] Antiangiogenic therapy for recurrent malignant glioma by bevacizumab monotherapy : Efficacy and prediction of response2012

    • Author(s)
      Nagane M, Tanaka M, 他4名
    • Organizer
      The 19^<th> International Brain Tumor Research and Therapy Conference
    • Place of Presentation
      Niagara Falls, Canada
    • Year and Date
      2012-06-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Bevacizumab monotherapy for recurrent malignant glioma ---Efficacy and prediction of response ---2012

    • Author(s)
      Nagane M, Tanaka M, 他4名
    • Organizer
      9^<th> Meeting of Asian Society for Neuro-Oncology
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2012-04-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 再発悪性神経膠腫に対する血管新生標的治療 : ベバシツマブ単独療法の効果と問題点2011

    • Author(s)
      永根基雄,田中雅樹, 他4名
    • Organizer
      第70回日本脳神経外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] CT及びMR perfusion imagesを用いた中枢神経系悪性リンパ腫と悪性神経膠腫の術前鑑別2011

    • Author(s)
      田中雅樹,永根基雄, 他3名
    • Organizer
      第70回日本脳神経外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Predictive value of mean apparent diffusion co-efficient value for responsiveness of temozolomide-refractory malignant glioma to bevacizumab2011

    • Author(s)
      Nagane M①, Tanaka M③, 他3名
    • Organizer
      2011 Annual Meeting of the American Society of Clinical Oncology
    • Place of Presentation
      Chicago, IL
    • Year and Date
      2011-06-04
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 中枢神経系原発悪性リンパ腫に対する大量AraC療法2011

    • Author(s)
      永根基雄,小林啓一,田中雅樹,畑中良,島田大輔,吉田裕毅,塩川芳昭
    • Organizer
      第15回 多摩脳腫瘍研究会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 中枢神経系原発悪性リンパ腫に対する大量AraC単独療法2011

    • Author(s)
      永根基雄,小林啓一,田中雅樹,塩川芳昭
    • Organizer
      第29回 日本脳腫瘍学会
    • Place of Presentation
      下呂、岐阜
    • Related Report
      2011 Research-status Report
  • [Presentation] CT perfusion及びMR perfusionを用いた中枢神経系悪性リンパ腫と悪性神経膠腫の術前鑑別2011

    • Author(s)
      田中雅樹、永根 基雄、小林 啓一、土屋 一洋、 塩川 芳昭
    • Organizer
      第70回 日本脳神経外科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] 再発悪性神経膠腫に対する血管新生標的治療:ベバシツマブ単独療法の効果と問題点2011

    • Author(s)
      永根基雄,小林啓一,田中雅樹,土屋一洋,原由紀子,塩川芳昭
    • Organizer
      第70回 日本脳神経外科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] Predictive value of mean apparent diffusion coefficient value for responsiveness of temozolomide-refractory malignant glioma to bevacizumab.2011

    • Author(s)
      Motoo Nagane, Keiichi Kobayashi, Masaki Tanaka, Kazuhiro Tsuchiya, Yoshiaki Shiokawa
    • Organizer
      The16th Annual Meeting of the Society for Neuro-Oncology
    • Place of Presentation
      Anaheim, CA, U.S.A
    • Related Report
      2011 Research-status Report
  • [Presentation] Antiangiogenic therapy for recurrent malignant glioma by bevacizumab monotherapy---Efficacy and future prospective---2011

    • Author(s)
      Motoo Nagane, Keiichi Kobayashi, Masaki Tanaka, Kazuhiro Tsuchiya, Yukiko Shishido-Hara, Yoshiaki Shiokawa
    • Organizer
      29th Annual Meeting of Japan Society for Neuro-Oncology
    • Place of Presentation
      Gero, Gifu, Japan
    • Related Report
      2011 Research-status Report
  • [Presentation] Gliomaの遺伝子異常と治療成績

    • Author(s)
      永根基雄
    • Organizer
      第31回 日本脳腫瘍病理学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 悪性脳腫瘍治療の現状と展望

    • Author(s)
      永根基雄
    • Organizer
      第8回岐阜脳腫瘍研究会
    • Place of Presentation
      岐阜市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Multidrug immunochemotherapy (R-MPV-A) for newly diagnosed and recurrent primary central nervous system lymphomas.

    • Author(s)
      Motoo Nagane, Keiichi Kobayashi, Nobuyuki Takayama, Yoshiaki Shiokawa
    • Organizer
      2013 The 4th Quadrennial Meeting of the World Federation of Neuro-Oncology /The18th Annual Meeting of the Society for Neuro-Oncology
    • Place of Presentation
      San Francisco, CA, U.S.A.
    • Related Report
      2013 Annual Research Report
  • [Presentation] Bevacizumab monotherapy for recurrent malignant glioma ---Efficacy and prediction of response ---

    • Author(s)
      Motoo Nagane, Keiichi Kobayashi, Masaki Tanaka, Kazuhiro Tsuchiya, Yukiko Shishido-Hara, Yoshiaki Shiokawa
    • Organizer
      9th Meeting of Asian Society for Neuro-Oncology
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2012 Research-status Report
  • [Presentation] CT及びMR perfusion imagesを用いた中枢神経系悪性リンパ腫と悪性神経膠腫の術前鑑別

    • Author(s)
      永根基雄,田中雅樹,小林啓一,土屋一洋,塩川芳昭
    • Organizer
      第17回 多摩脳腫瘍研究会
    • Place of Presentation
      三鷹市,東京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Antiangiogenic therapy for recurrent malignant glioma by bevacizumab monotherapy: Efficacy and prediction of response

    • Author(s)
      Motoo Nagane, Keiichi Kobayashi, Masaki Tanaka, Kazuhiro Tsuchiya, Yukiko Shishido-Hara, Yoshiaki Shiokawa
    • Organizer
      The 19th International Brain Tumor Research and Therapy Conference
    • Place of Presentation
      Niagara Falls, Canada
    • Related Report
      2012 Research-status Report
  • [Book] 脳腫瘍Brain tumor.In今日の治療と看護改訂第3版2013

    • Author(s)
      田中雅樹,永根基雄(永井良三,大田健(総編))
    • Publisher
      南江堂
    • Related Report
      2013 Final Research Report
  • [Book] 今日の治療と看護 改訂第3版2013

    • Author(s)
      田中雅樹,永根基雄
    • Publisher
      南江堂
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/~kyorin-n/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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