| Project/Area Number |
23791626
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
NOTOMI Takuya 東京医科歯科大学, 歯と骨のGCOE拠点, 特任講師 (70542249)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 膜電位 / 骨代謝 / 破骨細胞 / イオンチャネル |
|---|
| Research Abstract |
Bone diseases are serious problem in an aged society and their treatment is necessary for maintaining QOL. To prevent bone diseases, we have done the study of effects of ion channels and membrane potential in bone. To investigate the signaling mechanism via ion channel and receptor, we examined the function of bone cells by light-sensitive ion channel and pump. The light-gated ion channels and pump were transfected into bone cells and then the role of membrane potential on those cells were investigated. Further, based on their results, we identified bone remodeling-related novel ion channels. In summary, our results indicate that membrane potential regulate bone cell function and bone remodeling-related novel ion channels are important for osteoclastic functions.
|
