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Development of a method of enhancing antitumor drug delivery byextracellular environment control

Research Project

Project/Area Number 23791634
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionMie University

Principal Investigator

MATSUBARA Takao  三重大学, 医学部附属病院, 助教 (30422827)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords骨・軟部腫瘍学 / 悪性腫瘍 / 細胞外環境 / 低pH / 低酸素 / 薬剤感受性 / 腫瘍細胞環境 / 光線力学的療法 / 骨軟部腫瘍 / 酸性度 / 高静水圧 / 低栄養 / 抗がん剤治療
Research Abstract

The results of this study showed that osteosarcoma, lung cancer and gastric cancer cells which exposed to the complex tumor micro-environment (i.e. high hydrostaticpressure, hypoxic, acidic and low nutrition) controlled their own cell growth and invasiveness and metastasis ability to survie in such severe tumor micro-environmental condition. On the other hand, the release of various cytokines for survive can be integrated to amplify acridine orangewhich is a photosensitizer for malignant tumors, and the contol of micro-tumor environmentenhance the cytotoxic effects by photodynamic therapy.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (59 results)

All 2013 2012 2011 Other

All Journal Article (18 results) (of which Peer Reviewed: 16 results) Presentation (41 results)

  • [Journal Article] Can a less radical surgery using photodynamic therapy with acridine orange be equal to a wide-margin resection?2013

    • Author(s)
      Matsubara T, Kusuzaki K, Matsumine A, Nakamura T, Sudo A.
    • Journal Title

      Clin Orthop Relat Res

      Volume: 471(3) Issue: 3 Pages: 792-802

    • DOI

      10.1007/s11999-012-2616-9

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Translational research of photodynamic therapy with acridine orange which targets cancer acidity2012

    • Author(s)
      Kusuzaki K, Hosogi S, Ashihara E, Matsubara T, Satonaka H, Nakamura T, Matsumine A, Sudo A, Uchida A, Murata H, Baldini N, Fais S, Marunaka Y
    • Journal Title

      Curr Pharm Des

      Volume: 18(10) Pages: 1414-20

    • Related Report
      2012 Final Research Report
  • [Journal Article] Translational research of photodynamic therapy with acridine orange which targets cancer acidity2012

    • Author(s)
      Kusuzaki K, Hosogi S, Ashihara E, Matsubara T, Satonaka H, Nakamura T, Matsumine A, Sudo A, Uchida A, Murata H, Baldini N, Fais S, Marunaka Y.
    • Journal Title

      Curr Pharm Des

      Volume: 18 Issue: 10 Pages: 1414-1420

    • DOI

      10.2174/138161212799504812

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of pretreatment serum C-reactive protein level in soft tissue sarcoma2012

    • Author(s)
      Nakamura T, Matsumine A, Matsubara T, Asanuma K, Uchida A, Sudo A
    • Journal Title

      Cancer

      Volume: 118(4) Issue: 4 Pages: 1055-61

    • DOI

      10.1002/cncr.26353

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acridine orange inhibits pulmonary metastasis of mouse osteosarcoma2011

    • Author(s)
      Satonaka H, Kusuzaki K, Akeda K, Tsujii M, Iino T, Uemura T, Matsubara T, Nakamura T, Asanuma K, Matsumine A, Sudo A
    • Journal Title

      Anticancer Res.

      Volume: 31(12) Pages: 4163-8

    • Related Report
      2012 Final Research Report
  • [Journal Article] Acridine orange inhibits pulmonary metastasis of mouse osteosarcoma.2011

    • Author(s)
      Satonaka H, Kusuzaki K, Akeda K, Tsujii M, Iino T, Uemura T, Matsubara T, Nakamura T, Asanuma K, Matsumine A, Sudo A.
    • Journal Title

      Anticancer Res.

      Volume: 31(12) Pages: 4163-8

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The adverse effect of an unplanned surgical excision of foot soft tissue sarcoma.2011

    • Author(s)
      Nishimura A, Matsumine A, Asanuma K, Matsubara T, Nakamura T, Uchida A, Kato K, Sudo A.
    • Journal Title

      World J Surg Oncol.

      Volume: 9 Pages: 160-160

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical impact of the tumor volume doubling time on sarcoma patients with lung metastases.2011

    • Author(s)
      Nakamura T, Matsumine A, Matsubara T, Asanuma K, Uchida A, Sudo A.
    • Journal Title

      Clin Exp Metastasis.

      Volume: 28(8) Pages: 819-25

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The symptom-to-diagnosis delay in soft tissue sarcoma influence the overall survival and the development of distant metastasis2011

    • Author(s)
      Nakamura T, Matsumine A, Matsubara T, Asanuma K, Uchida A, Sudo A
    • Journal Title

      J Surg Oncol

      Volume: 104(7) Issue: 7 Pages: 771-5

    • DOI

      10.1002/jso.22006

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel hyperthermia treatment for bone metastases using magnetic materials.2011

    • Author(s)
      Matsumine A, Takegami K, Asanuma K, Matsubara T, Nakamura T, Uchida A, Sudo A.
    • Journal Title

      Int J Clin Oncol.

      Volume: 16(2) Pages: 101-8

    • NAID

      10029366305

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 環椎溶骨性変化に斜頸を合併したspinal osseous epidural AVFの1例.2011

    • Author(s)
      奥野一真, 松原孝夫, 中村知樹, 浅沼邦洋, 松峯昭彦, 須藤啓広.
    • Journal Title

      中部日本整形外科災害外科学会雑誌

      Volume: 54(1) Pages: 147-148

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 当院における高齢者骨肉腫の予後規定因子の検討2011

    • Author(s)
      淺沼邦洋, 松峯昭彦, 松原孝夫, 中村知樹, 内田淳正, 須藤啓広 .
    • Journal Title

      中部日本整形外科災害外科学会雑誌

      Volume: 54(1) Pages: 81-82

    • NAID

      10029071256

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 骨肉腫・ユーイング肉腫に対するアクリジンオレンジ光線および放射線力学的療法の治療成績.2011

    • Author(s)
      松原孝夫, 楠崎克之, 中村知樹, 松峯昭彦, 内田淳正, 須藤啓広 .
    • Journal Title

      中部日本整形外科災害外科学会雑誌

      Volume: 54(1) Pages: 73-74

    • NAID

      10029071238

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 肺転移に対しGemcitabineが有効であった骨肉腫の1例.2011

    • Author(s)
      渥美覚, 松峯昭彦, 中村知樹, 松原孝夫, 淺沼邦洋, 須藤啓広 .
    • Journal Title

      中部日本整形外科災害外科学会雑誌

      Volume: 54(1) Pages: 59-60

    • NAID

      10029071197

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 軟部肉腫における不適切切除後の広範切除症例に対するMRIの有効性2011

    • Author(s)
      中村知樹, 松峯昭彦, 松原孝夫, 浅沼邦洋, 須藤啓広
    • Journal Title

      中部日本整形外科災害外科学会雑誌

      Volume: 54(1) Pages: 39-40

    • NAID

      10029071134

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 骨外性粘液型軟骨肉腫の治療成績2011

    • Author(s)
      中村知樹, 松峯昭彦, 松原孝夫, 淺沼邦洋, 楠崎克之, 須藤啓広
    • Journal Title

      整形外科

      Volume: 62(6) Pages: 513-516

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 悪性骨軟部腫瘍における腫瘍細胞外pHと予後の検討2011

    • Author(s)
      松原孝夫, 楠崎克之, 中村知樹, 浅沼邦洋, 松峯昭彦, 須藤啓広.
    • Journal Title

      中部日本整形外科災害外科学会雑誌

      Volume: 54(4) Pages: 745-746

    • NAID

      10029661608

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 悪性骨軟部腫瘍における腫瘍細胞外pHと予後の検討.2011

    • Author(s)
      松原孝夫, 楠崎克之, 中村知樹, 浅沼邦洋, 松峯昭彦, 須藤啓広.
    • Journal Title

      中部日本整形外科災害外科学会雑誌

      Volume: 54(4) Pages: 745-746

    • NAID

      10029661608

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Acridine Orange Therapy as a New Less-invasive Limb Salvage Surgery for Rhabdomyosarcomas and Synovial Sarcomas.2013

    • Author(s)
      Takao Matsubara, Katsuyuki Kusuzaki, Akihiko Matsumine, Kunihiro Asanuma, Tomoki Nakamura, Akihiro Sudo
    • Organizer
      AAOS (American Association of Orthopaedic Surgeons) 2013 Annual Meeting
    • Place of Presentation
      Chicago, IL
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 化学療法感受性腫瘍に対するアクリジンオレンジ療法の検討2012

    • Author(s)
      松原孝夫、楠崎克之、松峯昭彦、中村知樹、浅沼邦洋、須藤啓広
    • Organizer
      AO治療研究会
    • Place of Presentation
      京都
    • Year and Date
      2012-12-08
    • Related Report
      2012 Final Research Report
  • [Presentation] A new therapeutic limb salvage surgery using acridine orange in patients with bone sarcomas2012

    • Author(s)
      Takao Matsubara, Katsuyuki Kusuzaki, Akihiko Matsumine, Akihiro Sudo
    • Organizer
      AAOS (American Academy of Orthopaedic Surgerons) 2012 Annual Meeting
    • Place of Presentation
      San Francisco, CA
    • Related Report
      2012 Final Research Report
  • [Presentation] The Synergistic Tumor Micro-environmental Effect of Extracellular pH, pO2, and Pressure controlled Invasiveness and Survival on Human Osteosarcoma Cells2012

    • Author(s)
      Takao Matsubara, Akihiro Sudo, Gene R DiResta, John H Healey.
    • Organizer
      ORS (Orthopaedic Research Society)2012 Annual Meeting
    • Place of Presentation
      San Francisco, CA
    • Related Report
      2012 Final Research Report
  • [Presentation] A New Therapeutic Photodynamic Surgery Using Acridine Orange for Rhabdomyosarcomas and Synovial Sarcomas.2012

    • Author(s)
      Takao Matsubara, Katsuyuki Kusuzaki, Akihiko Matsumine, Kunihiro Asanuma, Tomoki Nakamura, Atsumasa Uchida, Akihiro Sudo
    • Organizer
      APMSTS (Asia Pacific Musculoskeletal Tumor Society) Meeting
    • Place of Presentation
      Kuala lumpur, Malaysia
    • Related Report
      2012 Final Research Report
  • [Presentation] A minimally invasive surgery for bone metastases using photodynamic therapy with acridine orange2012

    • Author(s)
      Takao Matsubara, Katsuyuki Kusuzaki, Akihiko Matsumine, Kunihiro Asanuma, Tomoki Nakamura, Atsumasa Uchida, Akihiro Sudo
    • Organizer
      A minimally invasive surgery for bone metastases using photodynamic therapy with acridine orange
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Acridine orange used for photodynamic therapy accumulates in malignant tumor cells by control the tumor microenvironments.2012

    • Author(s)
      Takao Matsubara,Katsuyuki Kusuzaki, Akihiko Matsumine, Kunihiro Asanuma, Tomoki Nakamura, Atsumasa Uchida, Akihiro Sudo
    • Organizer
      ISPDC (Internationl Society for Proton Dynamics in Cancer) 3rd Symposium
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] A MINIMALLY INVASIVE SURGERY FOR BONE METASTASES USING THE COMBINATION OF PHOTODYNAMIC THERAPY AND HYPERTHERMIA TREATMENT2012

    • Author(s)
      Takao Matsubara, Katsuyuki Kusuzaki, Akihiko Matsumine, Kunihiro Asanuma, Tomoki Nakamura, Atsumasa Uchida, Akihiro Sudo.
    • Organizer
      CTOS (Connective Tissue Oncology Society) 17th Annual Meeting
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2012 Final Research Report
  • [Presentation] 緩和的治療としての転移性骨腫瘍に対するアクリジンオレンジ療法および磁性体温熱療法併用治療2012

    • Author(s)
      松原孝夫、楠崎克之、松峯昭彦、中村知樹、浅沼邦洋、須藤啓広
    • Organizer
      中部日本整形災害外科学会 第120回学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] 転移性骨腫瘍に対するアクリジンオレンジ光線力学的療法および磁性体温熱療法併用治療法の検討2012

    • Author(s)
      松原孝夫 楠崎克之 松峯昭彦 浅沼邦洋中村知樹 内田淳正 須藤啓広
    • Organizer
      71回 日本癌学会学術集会
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨肉腫細胞における細胞外環境因子とアクリジンオレンジ腫瘍内集積濃度の関係2012

    • Author(s)
      松原孝夫楠崎克之 松峯昭彦 浅沼邦洋 中村知樹 内田淳正 須藤啓広
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Related Report
      2012 Final Research Report
  • [Presentation] 緩和的治療としての転移性骨腫瘍に対するアクリジンオレンジ療法および磁性体温熱療法併用治療2012

    • Author(s)
      松原孝夫、楠崎克之、松峯昭彦、中村知樹、浅沼邦洋、須藤啓広
    • Organizer
      中部日本整形災害外科学会 第120回学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] A New Therapeutic Photodynamic Surgery Using Acridine Orange for Rhabdomyosarcomas and Synovial Sarcomas.2012

    • Author(s)
      Takao Matsubara, Katsuyuki Kusuzaki, Akihiko Matsumine, Kunihiro Asanuma, Tomoki Nakamura, Atsumasa Uchida, Akihiro Sudo
    • Organizer
      APMSTS (Asia Pacific Musculoskeletal Tumor Society) Meeting 2012
    • Place of Presentation
      Kuala lumpur, Malaysia
    • Related Report
      2012 Annual Research Report
  • [Presentation] 転移性骨腫瘍に対するアクリジンオレンジ光線力学的療法および磁性体温熱療法併用治療法の検討2012

    • Author(s)
      松原孝夫 楠崎克之 松峯昭彦 浅沼邦洋 中村知樹 内田淳正 須藤啓広
    • Organizer
      71回 日本癌学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] A minimally invasive surgery for bone metastases using photodynamic therapy with acridine orange.2012

    • Author(s)
      Takao Matsubara, Katsuyuki Kusuzaki, Akihiko Matsumine, Kunihiro Asanuma, Tomoki Nakamura, Atsumasa Uchida, Akihiro Sudo
    • Organizer
      9. ISPDC (Internationl Society for Proton Dynamics in Cancer) 3rd Symposium
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨肉腫細胞における細胞外環境因子とアクリジンオレンジ腫瘍内集積濃度の関係2012

    • Author(s)
      松原孝夫 楠崎克之 松峯昭彦 浅沼邦洋 中村知樹 内田淳正 須藤啓広
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] A MINIMALLY INVASIVE SURGERY FOR BONE METASTASES USING THE COMBINATION OF PHOTODYNAMIC THERAPY AND HYPERTHERMIA TREATMENT.2012

    • Author(s)
      Takao Matsubara, Katsuyuki Kusuzaki, Akihiko Matsumine, Kunihiro Asanuma, Tomoki Nakamura, Atsumasa Uchida, Akihiro Sudo
    • Organizer
      CTOS (Connective Tissue Oncology Society) 17th Annual Meeting
    • Place of Presentation
      Prague, Czech Republic.
    • Related Report
      2012 Annual Research Report
  • [Presentation] A Novel Oncolytic Virotherapy Using Live-attenuated Poliovirus for Soft Tissue Sarcoma.2012

    • Author(s)
      S. Atsumi, A. Matsumine, Y. Asanuma, N. Akita,T. Yoshikawa, K. Yoshida, T. Matsubara, T.Nakamura, T. Okamoto, T. Hayashi, A. Uchida,A. Sudo.
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      California
    • Related Report
      2011 Research-status Report
  • [Presentation] Analysis of tumor metastatic using low coagulation activity model in mice.2012

    • Author(s)
      K. Asanuma, A. Matsumine, Y. Asanuma, N.Akita, T. Yoshikawa, K. Yoshida, T. Matsubara,To. Nakamura, T. Okamoto, T. Hayashi, A.Uchida, A. Sudo.
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      California
    • Related Report
      2011 Research-status Report
  • [Presentation] Acridine Orange Inhibits Pulmonary Metastasis and Invasion on Mouse Oseteosarcoma.2012

    • Author(s)
      Haruhiko Satanaka, Koji Akeda, Katsuyuki Kusuzaki, Masaya Tujii, Takahiro Iino, Takeshi Uemura, Tomoki Nakamura, Takao Matsubara,Kunihiro Asanuma, Akihiko Matsumine, Akihiro Sudo.
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      California
    • Related Report
      2011 Research-status Report
  • [Presentation] 悪性軟部腫瘍におけるアクリジンオレンジ療法至適症例の検討2011

    • Author(s)
      松原孝夫, 楠崎克之, 松峯昭彦, 中村知樹、浅沼邦洋, 須藤啓広
    • Organizer
      第2回AO治療研究会
    • Place of Presentation
      京都
    • Year and Date
      2011-11-05
    • Related Report
      2012 Final Research Report
  • [Presentation] China Clinical Outcome of Acridine Orange Therapy Supported by Photodynamic Surgery and Radiodynamic Therapy for Soft Tissue Sarcomas, Compared with Conventional Limb Salvage Surgery after Wide Resection2011

    • Author(s)
      Takao Matsubara, Katsuyuki Kusuzaki, Hiroaki Murata, Akihiko Matsumine, Tomoki Nakamura, Kunihiro Asanuma, Atsumasa Uchida, Akihiro Sudo
    • Organizer
      ISOLS (International Symposium on Limb Salvage) 16th Meeting
    • Place of Presentation
      Beiging
    • Related Report
      2012 Final Research Report
  • [Presentation] Tumor Micro-environmental Effect of Extracellular pH, pO2, and Pressure controlled Invasiveness and Survival on Human Osteosarcoma Cells.2011

    • Author(s)
      Takao Matsubara, Akihiro Sudo, Gene R DiResta, John H Healey.
    • Organizer
      ISPDC (Symposium of the International Society for Proton Dynamics in Cancer) 2th Annual Meeting
    • Place of Presentation
      Nice, France
    • Related Report
      2012 Final Research Report
  • [Presentation] 悪性骨軟部腫瘍切除後の骨欠損に対する術中処理自家骨移植法の治療成績2011

    • Author(s)
      松原孝夫 松峯昭彦 楠崎克之 中村知樹 浅沼邦洋 渥美覚 内田淳正 須藤啓広
    • Organizer
      第43回日整会骨・軟部腫瘍学会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] 悪性骨軟部腫瘍における腫瘍細胞外pH と予後の検討2011

    • Author(s)
      松原孝夫、楠崎克之、中村知樹、浅沼邦洋、松峯昭彦、須藤啓広
    • Organizer
      第116回中部整形外科・災害外科学会
    • Place of Presentation
      高知
    • Related Report
      2012 Final Research Report
  • [Presentation] The inhibition of lung metastasis by inactivation of coagulation activity may lead to dissemination of tumor cells.2011

    • Author(s)
      K. Asanuma, A. Matsumine, Y. Asanuma, T. Yoshikawa, K. Yoshida, T. Matsubara, T. Nakamura, A. Uchida, A. Sudo.
    • Organizer
      EUROPEAN ORTHOPAEDIC RESEACH SOCIETY
    • Place of Presentation
      Austria
    • Related Report
      2011 Research-status Report
  • [Presentation] 軟部肉腫における診断の遅延が臨床経過に及ぼす影響2011

    • Author(s)
      中村知樹、松峯昭彦、松原孝夫、淺沼邦洋、渥美覚、内田淳正、須藤啓広.
    • Organizer
      第44回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report
  • [Presentation] 低悪性度軟骨肉腫の治療成績.2011

    • Author(s)
      渥美覚、松峯昭彦、淺沼邦洋、松原孝夫、中村知樹、内田淳正、須藤啓広.
    • Organizer
      第44回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report
  • [Presentation] アクリジンオレンジを用いた分子イメージングの低侵襲外科手術への応用.2011

    • Author(s)
      楠崎克之、松原孝夫、里中東彦、中村知樹、松峯昭彦、須藤啓広、内田淳正.
    • Organizer
      第44回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report
  • [Presentation] 下肢骨・軟部腫瘍術後の深部静脈血栓症の発生率と危険因子について.2011

    • Author(s)
      山口敏郎、松峯昭彦、施徳全、新美塁、中村知樹、松原孝夫、淺沼邦洋、長谷川正裕、須藤啓広.
    • Organizer
      第44回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report
  • [Presentation] 京セラ腫瘍用人工膝関節:PHK IIIの治療成績に関する追加調査報告 ―骨軟部肉腫治療研究会(JMOG)による多施設共同研究―2011

    • Author(s)
      松峯昭彦、上田孝文、杉田孝、矢澤康男、井須和男、平賀博明、川井章、阿部哲士、薬師寺俊剛、淺沼邦洋、松原孝夫、中村知樹、内田淳正、須藤啓広.
    • Organizer
      第44回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report
  • [Presentation] 悪性骨・軟部腫瘍切除後の骨欠損に対する術中処理自家骨移植法の治療成績.2011

    • Author(s)
      松原孝夫、松峯昭彦、楠崎克之、中村知樹、淺沼邦洋、渥美覚、内田淳正、須藤啓広.
    • Organizer
      第44回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report
  • [Presentation] 体外交流電磁場発生装置を用いた転移性骨腫瘍に対する電磁性体温熱療法.2011

    • Author(s)
      松峯昭彦、中村知樹、松原孝夫、淺沼邦洋、内田淳正、須藤啓広.
    • Organizer
      日本ハイパーサミーア学会 第28回大会
    • Place of Presentation
      名古屋市
    • Related Report
      2011 Research-status Report
  • [Presentation] 血液凝固抑制マウスを用いた肺転移関連因子の解析.2011

    • Author(s)
      淺沼邦洋、松峯昭彦、松原孝夫、中村知樹、吉川智朗、淺沼由美子、内田淳正、林辰弥、秋田展幸、岡本貴之、須藤啓広.
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋市
    • Related Report
      2011 Research-status Report
  • [Presentation] 高齢者の要介護認定に対する変形性膝関節症と骨粗鬆症の影響―旧宮川村検診より―2011

    • Author(s)
      西村明展、松峯昭彦、長谷川正裕、若林弘樹、明田浩司、淺沼邦洋、辻井雅也、里中東彦、松原孝夫、中村知樹、山田知美、加藤公、内田淳正、須藤啓広.
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋市
    • Related Report
      2011 Research-status Report
  • [Presentation] 弱毒ポリオ生ワクチンによる悪性骨・軟部腫瘍の新しい腫瘍融解療法.2011

    • Author(s)
      渥美覚、松峯昭彦、新美塁、中村知樹、松原孝夫、淺沼邦洋、豊田秀美、駒田美弘、内田淳正、須藤啓広.
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋市
    • Related Report
      2011 Research-status Report
  • [Presentation] 下腿遠位部悪性骨腫瘍に対する処理骨を用いた患肢温存の治療成績.2011

    • Author(s)
      松井佑梨世、中村知樹、松原孝夫、淺沼邦洋、松峯昭彦、須藤啓広.
    • Organizer
      第117回中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      宇部市
    • Related Report
      2011 Research-status Report
  • [Presentation] 大腿骨近位部の悪性骨軟部腫瘍に対する腫瘍用人工関節の治療成績2011

    • Author(s)
      淺沼邦洋、松峯昭彦、松原孝夫、中村知樹、内田淳正、須藤啓広.
    • Organizer
      第117回中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      宇部市
    • Related Report
      2011 Research-status Report
  • [Presentation] 血腫と診断された腫瘤の臨床および画像所見的特徴.2011

    • Author(s)
      渥美覚、松峯昭彦、中村知樹、松原孝夫、淺沼邦洋、須藤啓広
    • Organizer
      第117回中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      宇部市
    • Related Report
      2011 Research-status Report
  • [Presentation] 膝蓋靱帯・アキレス腱周囲に発生した悪性軟部腫瘍手術における術中自家腱処理法2011

    • Author(s)
      松原孝夫、松峯昭彦、淺沼邦洋、中村知樹、渥美覚、須藤啓広.
    • Organizer
      第117回中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      宇部市
    • Related Report
      2011 Research-status Report
  • [Presentation] 化学療法感受性腫瘍に対するアクリジンオレンジ療法の検討.

    • Author(s)
      松原孝夫、楠崎克之、松峯昭彦、中村知樹、浅沼邦洋、須藤啓広
    • Organizer
      AO治療研究会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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