Development of a method of enhancing antitumor drug delivery byextracellular environment control

• Project/Area Number: 23791634
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Mie University
• Principal Investigator: MATSUBARA Takao 三重大学, 医学部附属病院, 助教 (30422827)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 骨・軟部腫瘍学 / 悪性腫瘍 / 細胞外環境 / 低pH / 低酸素 / 薬剤感受性 / 腫瘍細胞環境 / 光線力学的療法 / 骨軟部腫瘍 / 酸性度 / 高静水圧 / 低栄養 / 抗がん剤治療

Research Abstract

The results of this study showed that osteosarcoma, lung cancer and gastric cancer cells which exposed to the complex tumor micro-environment (i.e. high hydrostaticpressure, hypoxic, acidic and low nutrition) controlled their own cell growth and invasiveness and metastasis ability to survie in such severe tumor micro-environmental condition. On the other hand, the release of various cytokines for survive can be integrated to amplify acridine orangewhich is a photosensitizer for malignant tumors, and the contol of micro-tumor environmentenhance the cytotoxic effects by photodynamic therapy.

Research Products

• [Journal Article] Can a less radical surgery using photodynamic therapy with acridine orange be equal to a wide-margin resection? (2013)
  • Author(s): Matsubara T, Kusuzaki K, Matsumine A, Nakamura T, Sudo A.
  • Journal Title: Clin Orthop Relat Res Volume: 471(3) Issue: 3 Pages: 792-802
  • DOI: 10.1007/s11999-012-2616-9
  • Peer Reviewed
• [Journal Article] Translational research of photodynamic therapy with acridine orange which targets cancer acidity (2012)
  • Author(s): Kusuzaki K, Hosogi S, Ashihara E, Matsubara T, Satonaka H, Nakamura T, Matsumine A, Sudo A, Uchida A, Murata H, Baldini N, Fais S, Marunaka Y
  • Journal Title: Curr Pharm Des Volume: 18(10) Pages: 1414-20
• [Journal Article] Translational research of photodynamic therapy with acridine orange which targets cancer acidity (2012)
  • Author(s): Kusuzaki K, Hosogi S, Ashihara E, Matsubara T, Satonaka H, Nakamura T, Matsumine A, Sudo A, Uchida A, Murata H, Baldini N, Fais S, Marunaka Y.
  • Journal Title: Curr Pharm Des Volume: 18 Issue: 10 Pages: 1414-1420
  • DOI: 10.2174/138161212799504812
  • Peer Reviewed
• [Journal Article] Clinical significance of pretreatment serum C-reactive protein level in soft tissue sarcoma (2012)
  • Author(s): Nakamura T, Matsumine A, Matsubara T, Asanuma K, Uchida A, Sudo A
  • Journal Title: Cancer Volume: 118(4) Issue: 4 Pages: 1055-61
  • DOI: 10.1002/cncr.26353
  • Peer Reviewed
• [Journal Article] Acridine orange inhibits pulmonary metastasis of mouse osteosarcoma (2011)
  • Author(s): Satonaka H, Kusuzaki K, Akeda K, Tsujii M, Iino T, Uemura T, Matsubara T, Nakamura T, Asanuma K, Matsumine A, Sudo A
  • Journal Title: Anticancer Res. Volume: 31(12) Pages: 4163-8
• [Journal Article] Acridine orange inhibits pulmonary metastasis of mouse osteosarcoma. (2011)
  • Author(s): Satonaka H, Kusuzaki K, Akeda K, Tsujii M, Iino T, Uemura T, Matsubara T, Nakamura T, Asanuma K, Matsumine A, Sudo A.
  • Journal Title: Anticancer Res. Volume: 31(12) Pages: 4163-8
  • Peer Reviewed
• [Journal Article] The adverse effect of an unplanned surgical excision of foot soft tissue sarcoma. (2011)
  • Author(s): Nishimura A, Matsumine A, Asanuma K, Matsubara T, Nakamura T, Uchida A, Kato K, Sudo A.
  • Journal Title: World J Surg Oncol. Volume: 9 Pages: 160-160
  • Peer Reviewed
• [Journal Article] Clinical impact of the tumor volume doubling time on sarcoma patients with lung metastases. (2011)
  • Author(s): Nakamura T, Matsumine A, Matsubara T, Asanuma K, Uchida A, Sudo A.
  • Journal Title: Clin Exp Metastasis. Volume: 28(8) Pages: 819-25
  • Peer Reviewed
• [Journal Article] The symptom-to-diagnosis delay in soft tissue sarcoma influence the overall survival and the development of distant metastasis (2011)
  • Author(s): Nakamura T, Matsumine A, Matsubara T, Asanuma K, Uchida A, Sudo A
  • Journal Title: J Surg Oncol Volume: 104(7) Issue: 7 Pages: 771-5
  • DOI: 10.1002/jso.22006
  • Peer Reviewed
• [Journal Article] A novel hyperthermia treatment for bone metastases using magnetic materials. (2011)
  • Author(s): Matsumine A, Takegami K, Asanuma K, Matsubara T, Nakamura T, Uchida A, Sudo A.
  • Journal Title: Int J Clin Oncol. Volume: 16(2) Pages: 101-8
  • NAID: 10029366305
  • Peer Reviewed
• [Journal Article] 環椎溶骨性変化に斜頸を合併したspinal osseous epidural AVFの1例. (2011)
  • Author(s): 奥野一真, 松原孝夫, 中村知樹, 浅沼邦洋, 松峯昭彦, 須藤啓広.
  • Journal Title: 中部日本整形外科災害外科学会雑誌 Volume: 54(1) Pages: 147-148
  • Peer Reviewed
• [Journal Article] 当院における高齢者骨肉腫の予後規定因子の検討 (2011)
  • Author(s): 淺沼邦洋, 松峯昭彦, 松原孝夫, 中村知樹, 内田淳正, 須藤啓広 .
  • Journal Title: 中部日本整形外科災害外科学会雑誌 Volume: 54(1) Pages: 81-82
  • NAID: 10029071256
  • Peer Reviewed
• [Journal Article] 骨肉腫・ユーイング肉腫に対するアクリジンオレンジ光線および放射線力学的療法の治療成績. (2011)
  • Author(s): 松原孝夫, 楠崎克之, 中村知樹, 松峯昭彦, 内田淳正, 須藤啓広 .
  • Journal Title: 中部日本整形外科災害外科学会雑誌 Volume: 54(1) Pages: 73-74
  • NAID: 10029071238
  • Peer Reviewed
• [Journal Article] 肺転移に対しGemcitabineが有効であった骨肉腫の1例. (2011)
  • Author(s): 渥美覚, 松峯昭彦, 中村知樹, 松原孝夫, 淺沼邦洋, 須藤啓広 .
  • Journal Title: 中部日本整形外科災害外科学会雑誌 Volume: 54(1) Pages: 59-60
  • NAID: 10029071197
  • Peer Reviewed
• [Journal Article] 軟部肉腫における不適切切除後の広範切除症例に対するMRIの有効性 (2011)
  • Author(s): 中村知樹, 松峯昭彦, 松原孝夫, 浅沼邦洋, 須藤啓広
  • Journal Title: 中部日本整形外科災害外科学会雑誌 Volume: 54(1) Pages: 39-40
  • NAID: 10029071134
  • Peer Reviewed
• [Journal Article] 骨外性粘液型軟骨肉腫の治療成績 (2011)
  • Author(s): 中村知樹, 松峯昭彦, 松原孝夫, 淺沼邦洋, 楠崎克之, 須藤啓広
  • Journal Title: 整形外科 Volume: 62(6) Pages: 513-516
  • Peer Reviewed
• [Journal Article] 悪性骨軟部腫瘍における腫瘍細胞外pHと予後の検討 (2011)
  • Author(s): 松原孝夫, 楠崎克之, 中村知樹, 浅沼邦洋, 松峯昭彦, 須藤啓広．
  • Journal Title: 中部日本整形外科災害外科学会雑誌 Volume: 54(4) Pages: 745-746
  • NAID: 10029661608
  • Peer Reviewed
• [Journal Article] 悪性骨軟部腫瘍における腫瘍細胞外pHと予後の検討． (2011)
  • Author(s): 松原孝夫, 楠崎克之, 中村知樹, 浅沼邦洋, 松峯昭彦, 須藤啓広．
  • Journal Title: 中部日本整形外科災害外科学会雑誌 Volume: 54(4) Pages: 745-746
  • NAID: 10029661608
  • Peer Reviewed
• [Presentation] Acridine Orange Therapy as a New Less-invasive Limb Salvage Surgery for Rhabdomyosarcomas and Synovial Sarcomas. (2013)
  • Author(s): Takao Matsubara, Katsuyuki Kusuzaki, Akihiko Matsumine, Kunihiro Asanuma, Tomoki Nakamura, Akihiro Sudo
  • Organizer: AAOS (American Association of Orthopaedic Surgeons) 2013 Annual Meeting
  • Place of Presentation: Chicago, IL
• [Presentation] 化学療法感受性腫瘍に対するアクリジンオレンジ療法の検討 (2012)
  • Author(s): 松原孝夫、楠崎克之、松峯昭彦、中村知樹、浅沼邦洋、須藤啓広
  • Organizer: AO治療研究会
  • Place of Presentation: 京都
  • Year and Date: 2012-12-08
• [Presentation] A new therapeutic limb salvage surgery using acridine orange in patients with bone sarcomas (2012)
  • Author(s): Takao Matsubara, Katsuyuki Kusuzaki, Akihiko Matsumine, Akihiro Sudo
  • Organizer: AAOS (American Academy of Orthopaedic Surgerons) 2012 Annual Meeting
  • Place of Presentation: San Francisco, CA
• [Presentation] The Synergistic Tumor Micro-environmental Effect of Extracellular pH, pO2, and Pressure controlled Invasiveness and Survival on Human Osteosarcoma Cells (2012)
  • Author(s): Takao Matsubara, Akihiro Sudo, Gene R DiResta, John H Healey.
  • Organizer: ORS (Orthopaedic Research Society)2012 Annual Meeting
  • Place of Presentation: San Francisco, CA
• [Presentation] A New Therapeutic Photodynamic Surgery Using Acridine Orange for Rhabdomyosarcomas and Synovial Sarcomas. (2012)
  • Author(s): Takao Matsubara, Katsuyuki Kusuzaki, Akihiko Matsumine, Kunihiro Asanuma, Tomoki Nakamura, Atsumasa Uchida, Akihiro Sudo
  • Organizer: APMSTS (Asia Pacific Musculoskeletal Tumor Society) Meeting
  • Place of Presentation: Kuala lumpur, Malaysia
• [Presentation] A minimally invasive surgery for bone metastases using photodynamic therapy with acridine orange (2012)
  • Author(s): Takao Matsubara, Katsuyuki Kusuzaki, Akihiko Matsumine, Kunihiro Asanuma, Tomoki Nakamura, Atsumasa Uchida, Akihiro Sudo
  • Organizer: A minimally invasive surgery for bone metastases using photodynamic therapy with acridine orange
  • Place of Presentation: Kyoto, Japan
• [Presentation] Acridine orange used for photodynamic therapy accumulates in malignant tumor cells by control the tumor microenvironments. (2012)
  • Author(s): Takao Matsubara,Katsuyuki Kusuzaki, Akihiko Matsumine, Kunihiro Asanuma, Tomoki Nakamura, Atsumasa Uchida, Akihiro Sudo
  • Organizer: ISPDC (Internationl Society for Proton Dynamics in Cancer) 3rd Symposium
  • Place of Presentation: Kyoto, Japan
• [Presentation] A MINIMALLY INVASIVE SURGERY FOR BONE METASTASES USING THE COMBINATION OF PHOTODYNAMIC THERAPY AND HYPERTHERMIA TREATMENT (2012)
  • Author(s): Takao Matsubara, Katsuyuki Kusuzaki, Akihiko Matsumine, Kunihiro Asanuma, Tomoki Nakamura, Atsumasa Uchida, Akihiro Sudo.
  • Organizer: CTOS (Connective Tissue Oncology Society) 17th Annual Meeting
  • Place of Presentation: Prague, Czech Republic
• [Presentation] 緩和的治療としての転移性骨腫瘍に対するアクリジンオレンジ療法および磁性体温熱療法併用治療 (2012)
  • Author(s): 松原孝夫、楠崎克之、松峯昭彦、中村知樹、浅沼邦洋、須藤啓広
  • Organizer: 中部日本整形災害外科学会 第120回学術集会
  • Place of Presentation: 大阪
• [Presentation] 転移性骨腫瘍に対するアクリジンオレンジ光線力学的療法および磁性体温熱療法併用治療法の検討 (2012)
  • Author(s): 松原孝夫 楠崎克之 松峯昭彦 浅沼邦洋中村知樹 内田淳正 須藤啓広
  • Organizer: 71回 日本癌学会学術集会
• [Presentation] 骨肉腫細胞における細胞外環境因子とアクリジンオレンジ腫瘍内集積濃度の関係 (2012)
  • Author(s): 松原孝夫楠崎克之 松峯昭彦 浅沼邦洋 中村知樹 内田淳正 須藤啓広
  • Organizer: 第27回日本整形外科学会基礎学術集会
• [Presentation] 緩和的治療としての転移性骨腫瘍に対するアクリジンオレンジ療法および磁性体温熱療法併用治療 (2012)
  • Author(s): 松原孝夫、楠崎克之、松峯昭彦、中村知樹、浅沼邦洋、須藤啓広
  • Organizer: 中部日本整形災害外科学会 第120回学術集会
  • Place of Presentation: 大阪
• [Presentation] A New Therapeutic Photodynamic Surgery Using Acridine Orange for Rhabdomyosarcomas and Synovial Sarcomas. (2012)
  • Author(s): Takao Matsubara, Katsuyuki Kusuzaki, Akihiko Matsumine, Kunihiro Asanuma, Tomoki Nakamura, Atsumasa Uchida, Akihiro Sudo
  • Organizer: APMSTS (Asia Pacific Musculoskeletal Tumor Society) Meeting 2012
  • Place of Presentation: Kuala lumpur, Malaysia
• [Presentation] 転移性骨腫瘍に対するアクリジンオレンジ光線力学的療法および磁性体温熱療法併用治療法の検討 (2012)
  • Author(s): 松原孝夫 楠崎克之 松峯昭彦 浅沼邦洋 中村知樹 内田淳正 須藤啓広
  • Organizer: 71回 日本癌学会学術集会
  • Place of Presentation: 札幌
• [Presentation] A minimally invasive surgery for bone metastases using photodynamic therapy with acridine orange. (2012)
  • Author(s): Takao Matsubara, Katsuyuki Kusuzaki, Akihiko Matsumine, Kunihiro Asanuma, Tomoki Nakamura, Atsumasa Uchida, Akihiro Sudo
  • Organizer: 9. ISPDC (Internationl Society for Proton Dynamics in Cancer) 3rd Symposium
  • Place of Presentation: Kyoto, Japan
• [Presentation] 骨肉腫細胞における細胞外環境因子とアクリジンオレンジ腫瘍内集積濃度の関係 (2012)
  • Author(s): 松原孝夫 楠崎克之 松峯昭彦 浅沼邦洋 中村知樹 内田淳正 須藤啓広
  • Organizer: 第27回日本整形外科学会基礎学術集会
  • Place of Presentation: 名古屋
• [Presentation] A MINIMALLY INVASIVE SURGERY FOR BONE METASTASES USING THE COMBINATION OF PHOTODYNAMIC THERAPY AND HYPERTHERMIA TREATMENT. (2012)
  • Author(s): Takao Matsubara, Katsuyuki Kusuzaki, Akihiko Matsumine, Kunihiro Asanuma, Tomoki Nakamura, Atsumasa Uchida, Akihiro Sudo
  • Organizer: CTOS (Connective Tissue Oncology Society) 17th Annual Meeting
  • Place of Presentation: Prague, Czech Republic.
• [Presentation] A Novel Oncolytic Virotherapy Using Live-attenuated Poliovirus for Soft Tissue Sarcoma. (2012)
  • Author(s): S. Atsumi, A. Matsumine, Y. Asanuma, N. Akita,T. Yoshikawa, K. Yoshida, T. Matsubara, T.Nakamura, T. Okamoto, T. Hayashi, A. Uchida,A. Sudo.
  • Organizer: Orthopaedic Research Society
  • Place of Presentation: California
• [Presentation] Analysis of tumor metastatic using low coagulation activity model in mice. (2012)
  • Author(s): K. Asanuma, A. Matsumine, Y. Asanuma, N.Akita, T. Yoshikawa, K. Yoshida, T. Matsubara,To. Nakamura, T. Okamoto, T. Hayashi, A.Uchida, A. Sudo.
  • Organizer: Orthopaedic Research Society
  • Place of Presentation: California
• [Presentation] Acridine Orange Inhibits Pulmonary Metastasis and Invasion on Mouse Oseteosarcoma. (2012)
  • Author(s): Haruhiko Satanaka, Koji Akeda, Katsuyuki Kusuzaki, Masaya Tujii, Takahiro Iino, Takeshi Uemura, Tomoki Nakamura, Takao Matsubara,Kunihiro Asanuma, Akihiko Matsumine, Akihiro Sudo.
  • Organizer: Orthopaedic Research Society
  • Place of Presentation: California
• [Presentation] 悪性軟部腫瘍におけるアクリジンオレンジ療法至適症例の検討 (2011)
  • Author(s): 松原孝夫, 楠崎克之, 松峯昭彦, 中村知樹、浅沼邦洋, 須藤啓広
  • Organizer: 第2回AO治療研究会
  • Place of Presentation: 京都
  • Year and Date: 2011-11-05
• [Presentation] China Clinical Outcome of Acridine Orange Therapy Supported by Photodynamic Surgery and Radiodynamic Therapy for Soft Tissue Sarcomas, Compared with Conventional Limb Salvage Surgery after Wide Resection (2011)
  • Author(s): Takao Matsubara, Katsuyuki Kusuzaki, Hiroaki Murata, Akihiko Matsumine, Tomoki Nakamura, Kunihiro Asanuma, Atsumasa Uchida, Akihiro Sudo
  • Organizer: ISOLS (International Symposium on Limb Salvage) 16th Meeting
  • Place of Presentation: Beiging
• [Presentation] Tumor Micro-environmental Effect of Extracellular pH, pO2, and Pressure controlled Invasiveness and Survival on Human Osteosarcoma Cells. (2011)
  • Author(s): Takao Matsubara, Akihiro Sudo, Gene R DiResta, John H Healey.
  • Organizer: ISPDC (Symposium of the International Society for Proton Dynamics in Cancer) 2th Annual Meeting
  • Place of Presentation: Nice, France
• [Presentation] 悪性骨軟部腫瘍切除後の骨欠損に対する術中処理自家骨移植法の治療成績 (2011)
  • Author(s): 松原孝夫 松峯昭彦 楠崎克之 中村知樹 浅沼邦洋 渥美覚 内田淳正 須藤啓広
  • Organizer: 第43回日整会骨・軟部腫瘍学会
  • Place of Presentation: 京都
• [Presentation] 悪性骨軟部腫瘍における腫瘍細胞外pH と予後の検討 (2011)
  • Author(s): 松原孝夫、楠崎克之、中村知樹、浅沼邦洋、松峯昭彦、須藤啓広
  • Organizer: 第116回中部整形外科・災害外科学会
  • Place of Presentation: 高知
• [Presentation] The inhibition of lung metastasis by inactivation of coagulation activity may lead to dissemination of tumor cells. (2011)
  • Author(s): K. Asanuma, A. Matsumine, Y. Asanuma, T. Yoshikawa, K. Yoshida, T. Matsubara, T. Nakamura, A. Uchida, A. Sudo.
  • Organizer: EUROPEAN ORTHOPAEDIC RESEACH SOCIETY
  • Place of Presentation: Austria
• [Presentation] 軟部肉腫における診断の遅延が臨床経過に及ぼす影響 (2011)
  • Author(s): 中村知樹、松峯昭彦、松原孝夫、淺沼邦洋、渥美覚、内田淳正、須藤啓広.
  • Organizer: 第44回日本整形外科学会骨･軟部腫瘍学術集会
  • Place of Presentation: 京都市
• [Presentation] 低悪性度軟骨肉腫の治療成績. (2011)
  • Author(s): 渥美覚、松峯昭彦、淺沼邦洋、松原孝夫、中村知樹、内田淳正、須藤啓広.
  • Organizer: 第44回日本整形外科学会骨･軟部腫瘍学術集会
  • Place of Presentation: 京都市
• [Presentation] アクリジンオレンジを用いた分子イメージングの低侵襲外科手術への応用. (2011)
  • Author(s): 楠崎克之、松原孝夫、里中東彦、中村知樹、松峯昭彦、須藤啓広、内田淳正.
  • Organizer: 第44回日本整形外科学会骨･軟部腫瘍学術集会
  • Place of Presentation: 京都市
• [Presentation] 下肢骨･軟部腫瘍術後の深部静脈血栓症の発生率と危険因子について. (2011)
  • Author(s): 山口敏郎、松峯昭彦、施徳全、新美塁、中村知樹、松原孝夫、淺沼邦洋、長谷川正裕、須藤啓広.
  • Organizer: 第44回日本整形外科学会骨･軟部腫瘍学術集会
  • Place of Presentation: 京都市
• [Presentation] 京セラ腫瘍用人工膝関節:PHK IIIの治療成績に関する追加調査報告 ―骨軟部肉腫治療研究会(JMOG)による多施設共同研究― (2011)
  • Author(s): 松峯昭彦、上田孝文、杉田孝、矢澤康男、井須和男、平賀博明、川井章、阿部哲士、薬師寺俊剛、淺沼邦洋、松原孝夫、中村知樹、内田淳正、須藤啓広.
  • Organizer: 第44回日本整形外科学会骨･軟部腫瘍学術集会
  • Place of Presentation: 京都市
• [Presentation] 悪性骨･軟部腫瘍切除後の骨欠損に対する術中処理自家骨移植法の治療成績. (2011)
  • Author(s): 松原孝夫、松峯昭彦、楠崎克之、中村知樹、淺沼邦洋、渥美覚、内田淳正、須藤啓広.
  • Organizer: 第44回日本整形外科学会骨･軟部腫瘍学術集会
  • Place of Presentation: 京都市
• [Presentation] 体外交流電磁場発生装置を用いた転移性骨腫瘍に対する電磁性体温熱療法. (2011)
  • Author(s): 松峯昭彦、中村知樹、松原孝夫、淺沼邦洋、内田淳正、須藤啓広.
  • Organizer: 日本ハイパーサミーア学会 第28回大会
  • Place of Presentation: 名古屋市
• [Presentation] 血液凝固抑制マウスを用いた肺転移関連因子の解析. (2011)
  • Author(s): 淺沼邦洋、松峯昭彦、松原孝夫、中村知樹、吉川智朗、淺沼由美子、内田淳正、林辰弥、秋田展幸、岡本貴之、須藤啓広.
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: 前橋市
• [Presentation] 高齢者の要介護認定に対する変形性膝関節症と骨粗鬆症の影響―旧宮川村検診より― (2011)
  • Author(s): 西村明展、松峯昭彦、長谷川正裕、若林弘樹、明田浩司、淺沼邦洋、辻井雅也、里中東彦、松原孝夫、中村知樹、山田知美、加藤公、内田淳正、須藤啓広.
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: 前橋市
• [Presentation] 弱毒ポリオ生ワクチンによる悪性骨･軟部腫瘍の新しい腫瘍融解療法. (2011)
  • Author(s): 渥美覚、松峯昭彦、新美塁、中村知樹、松原孝夫、淺沼邦洋、豊田秀美、駒田美弘、内田淳正、須藤啓広.
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: 前橋市
• [Presentation] 下腿遠位部悪性骨腫瘍に対する処理骨を用いた患肢温存の治療成績. (2011)
  • Author(s): 松井佑梨世、中村知樹、松原孝夫、淺沼邦洋、松峯昭彦、須藤啓広.
  • Organizer: 第117回中部日本整形外科災害外科学会･学術集会
  • Place of Presentation: 宇部市
• [Presentation] 大腿骨近位部の悪性骨軟部腫瘍に対する腫瘍用人工関節の治療成績 (2011)
  • Author(s): 淺沼邦洋、松峯昭彦、松原孝夫、中村知樹、内田淳正、須藤啓広.
  • Organizer: 第117回中部日本整形外科災害外科学会･学術集会
  • Place of Presentation: 宇部市
• [Presentation] 血腫と診断された腫瘤の臨床および画像所見的特徴. (2011)
  • Author(s): 渥美覚、松峯昭彦、中村知樹、松原孝夫、淺沼邦洋、須藤啓広
  • Organizer: 第117回中部日本整形外科災害外科学会･学術集会
  • Place of Presentation: 宇部市
• [Presentation] 膝蓋靱帯･アキレス腱周囲に発生した悪性軟部腫瘍手術における術中自家腱処理法 (2011)
  • Author(s): 松原孝夫、松峯昭彦、淺沼邦洋、中村知樹、渥美覚、須藤啓広.
  • Organizer: 第117回中部日本整形外科災害外科学会･学術集会
  • Place of Presentation: 宇部市
• [Presentation] 化学療法感受性腫瘍に対するアクリジンオレンジ療法の検討.
  • Author(s): 松原孝夫、楠崎克之、松峯昭彦、中村知樹、浅沼邦洋、須藤啓広
  • Organizer: AO治療研究会
  • Place of Presentation: 京都