| Project/Area Number |
23791634
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Mie University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 骨・軟部腫瘍学 / 悪性腫瘍 / 細胞外環境 / 低pH / 低酸素 / 薬剤感受性 / 腫瘍細胞環境 / 光線力学的療法 / 骨軟部腫瘍 / 酸性度 / 高静水圧 / 低栄養 / 抗がん剤治療 |
|---|
| Research Abstract |
The results of this study showed that osteosarcoma, lung cancer and gastric cancer cells which exposed to the complex tumor micro-environment (i.e. high hydrostaticpressure, hypoxic, acidic and low nutrition) controlled their own cell growth and invasiveness and metastasis ability to survie in such severe tumor micro-environmental condition. On the other hand, the release of various cytokines for survive can be integrated to amplify acridine orangewhich is a photosensitizer for malignant tumors, and the contol of micro-tumor environmentenhance the cytotoxic effects by photodynamic therapy.
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