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Reconstruction of spinal cord function using collagen filaments

Research Project

Project/Area Number 23791647
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionYamaguchi University

Principal Investigator

SUZUKI Hidenori  山口大学, 大学院・医学系研究科, 助教 (30393432)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords脊髄損傷 / scaffold / allodynia / 再生医療
Research Abstract

We obtained a lot of basic knowledge of the methods of anesthesia and management after surgery, and how to make the monkey’s SCI model. And on allodynia we made good scale using rat and mouse SCI models. In addition we succeeded to show the degree of allodynia using our new scale objectively. On CF transplantation to monkey SCI model, the results of tissue analysis were excellent and we confirmed that regenerated axons went through into the Collagen Filaments same as rat models in acute phase. But this is only analysis in a short term, so we have little data about motor functional recovery. This is the next theme and task for us.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (25 results)

All 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (19 results)

  • [Journal Article] 整形外科領域の疼痛治療2012

    • Author(s)
      鈴木秀典、田口敏彦
    • Journal Title

      Brain Medical

      Volume: 24巻 Pages: 37-44

    • Related Report
      2012 Final Research Report
  • [Journal Article] 疼痛治療の実際 腰痛・坐骨神経痛2012

    • Author(s)
      鈴木秀典、田口敏彦
    • Journal Title

      臨床と研究

      Volume: 89巻 Pages: 174-180

    • Related Report
      2012 Final Research Report
  • [Journal Article] 疼痛治療の実際 腰痛・坐骨神経痛2012

    • Author(s)
      鈴木秀典
    • Journal Title

      臨床と研究

      Volume: 89 Pages: 174-180

    • Related Report
      2012 Annual Research Report 2011 Research-status Report
  • [Journal Article] 整形外科領域の疼痛治療2012

    • Author(s)
      鈴木秀典
    • Journal Title

      BRAIN MEDICAL

      Volume: 24 Pages: 37-44

    • Related Report
      2012 Annual Research Report 2011 Research-status Report
  • [Journal Article] Transplantation of neurospheres derived from bone marrow stromal cells promotes neurological recovery in rats with spinal cord injury2011

    • Author(s)
      Hidenori Suzuki, Toshihiko Taguchi, Yoshihiko Kato, et al.(他 6名)
    • Journal Title

      Medical molecular morphology

      Volume: 44(3) Pages: 131-138

    • NAID

      10030463735

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transplantation of neurospheres derived from bone marrow stromal cells promotes neurological recovery in rats with spinal cord injury.2011

    • Author(s)
      Hidenori Suzuki, Toshihiko Taguchi, Yoshihiko Kato, et al
    • Journal Title

      Medical molecular morphology

      Volume: 44(3) Pages: 131-138

    • NAID

      10030463735

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 脊髄損傷ラットに対する_感覚機能評価スケールの検討2012

    • Author(s)
      鈴木秀典
    • Organizer
      第135回山口県整形外科医会
    • Place of Presentation
      千秋楽(山口)
    • Year and Date
      2012-12-01
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス脊髄圧挫損傷モデルにおける炎症性サイトカイン発現変化の検討2012

    • Author(s)
      村上智俊、鈴木秀典
    • Organizer
      第124回西日本整形・災害外科学会
    • Place of Presentation
      別府コンベンションセンター(大分)
    • Year and Date
      2012-11-17
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス脊髄圧挫損傷モデルに対する抗IL-6 受容体抗体の治療効果2012

    • Author(s)
      村上智俊、鈴木秀典
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2012-10-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 脊髄損傷ラットに対する感覚機能評価スケールの検討2012

    • Author(s)
      鈴木秀典
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2012-10-26
    • Related Report
      2012 Final Research Report
  • [Presentation] コラーゲンフィラメントの脊髄再生への応用2012

    • Author(s)
      鈴木秀典
    • Organizer
      第85回日本整形外科学会総会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2012-05-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 頸髄症術後患者における神経障害性疼痛2012

    • Author(s)
      鈴木秀典
    • Organizer
      第41回日本脊椎脊髄病学会
    • Place of Presentation
      石橋文化センター(久留米)
    • Year and Date
      2012-04-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Central Pain Syndrome after the operation of the Cervical Spondylotic Myelopathy2012

    • Author(s)
      Hidenori Suzuki
    • Organizer
      Society for Neuroscience 2012
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] A neuroprotective role of anti-interleukin-6(IL-6) receptor antibody following spinal cord injury (SCI) in mice2012

    • Author(s)
      Murakami Tomotoshi, Hidenori Suzuki
    • Organizer
      Society for Neuroscience 2012
    • Place of Presentation
      New Orleans, US
    • Related Report
      2012 Final Research Report
  • [Presentation] Combination therapy for rats with spinal cord injury -Collagen filaments as a scaffold and NT-3-2012

    • Author(s)
      Hidenori Suzuki
    • Organizer
      International Spinal Cord Society 2012
    • Place of Presentation
      London, UK
    • Related Report
      2012 Final Research Report
  • [Presentation] Central Pain Syndrome after the operation of the Cervical Spondylotic2012

    • Author(s)
      Hidenori Suzuki
    • Organizer
      Spine Across the Sea 2012
    • Place of Presentation
      Kauai, USA
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Central Pain Syndrome after the operation of the Cervical Spondylotic Myelopathy2012

    • Author(s)
      Hidenori Suzuki
    • Organizer
      Society for Neuroscience 2012
    • Place of Presentation
      New Orlens, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] A neuroprotective role of anti-interleukin-6(IL-6) receptor antibody following spinal cord injury (SCI) in mice2012

    • Author(s)
      Murakami Tomotoshi, Hidenori Suzuki
    • Organizer
      Society for Neuroscience 2012
    • Place of Presentation
      New Orlens, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Combination therapy for rats with spinal cord injury -Collagen filaments as a scaffold and NT-3-2012

    • Author(s)
      Hidenori Suzuki
    • Organizer
      International Spinal Cord Society 2012
    • Place of Presentation
      London, UK
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脊髄損傷ラットに対する 感覚機能評価スケールの検討

    • Author(s)
      鈴木秀典
    • Organizer
      第135回山口県整形外科医会
    • Place of Presentation
      千秋楽(山口)
    • Related Report
      2012 Annual Research Report
  • [Presentation] コラーゲンフィラメントの 脊髄再生への応用

    • Author(s)
      鈴木秀典
    • Organizer
      第85回日本整形外科学会総会
    • Place of Presentation
      京都国際会議場(京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス脊髄圧挫損傷モデルにおける炎症性サイトカイン発現変化の検討

    • Author(s)
      村上智俊、鈴木秀典
    • Organizer
      第124回西日本整形・災害外科学会
    • Place of Presentation
      別府コンベンションセンター(大分)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脊髄損傷ラットに対する 感覚機能評価スケールの検討

    • Author(s)
      鈴木秀典
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス脊髄圧挫損傷モデルに対する抗IL-6 受容体抗体の治療効果

    • Author(s)
      村上智俊、鈴木秀典
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 頸髄症術後患者における神経障害性疼痛

    • Author(s)
      鈴木秀典
    • Organizer
      第41回日本脊椎脊髄病学会
    • Place of Presentation
      石橋文化センター(久留米)
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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