| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Various point mutations of the Fibroblast Growth Factor Receptor(FGFR)3 Gene are known to cause short limb dwarfism. It is generally accepted that constitutive activation of the FGFR3 signaling is the main mechanism, but the severity of phenotype is not completely associated with the activation of FGFR3 signaling, suggesting the existence of the other mechanism. We showed the new mechanism that the accumulation of mutant FGFR3 in endoplasmic reticulum(ER) induced apoptosis of chondrocyte through ER stress.
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