Homing of circulating osteogenic progenitors to fracture healing site by administration of parathyroid hormone

• Project/Area Number: 23791652
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Yokohama City University
• Principal Investigator: KUMAGAI Ken 横浜市立大学, 医学部, 助教 (10468176)
• Research Collaborator: GEORGE F Muschler Cleveland Clinic, Orthopaedic Research Center, Director
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: PTH / 骨折治癒 / 骨前駆細胞 / ホーミング

Research Abstract

This study demonstrated that bone formation was stimulated through the homing of circulating osteogenic cells by the intermittent administration of parathyroid hormone in mouse femur fracture model. The data also suggested that SDF-1/CXCR4 contributed to the homing of the circulating osteogenic cells.

Research Products

• [Journal Article] The extent of degeneration of cruciate ligament is associated with chondrogenic differentiation in patients with osteoarthritis of the knee (2012)
  • Author(s): Kumagai K, Sakai K, Kusayama Y, Akamatsu Y, Sakamaki K, Morita S, Sasaki T, Saito T, Sakai T
  • Journal Title: Osteoarthritis Cartilage Volume: 20(11) Pages: 1258-67
  • Peer Reviewed
• [Journal Article] Low-intensity pulsed ultrasound accelerates fracture healing by stimulation of recruitment of both local and circulating osteogenic progenitors (2012)
  • Author(s): Kumagai K, Takeuchi R, Ishikawa H, Yamaguchi Y, Fujisawa T, Kuniya T, Takagawa S, Muschler GF, Saito T
  • Journal Title: J Orthop Res Volume: 30(9) Pages: 1516-21
  • Peer Reviewed
• [Journal Article] 誌上シンポジウム 高位脛骨骨切り術の適応と限界 Opening wedge 法 (2012)
  • Author(s): 熊谷研, 齋藤知行
  • Journal Title: 臨床整形外科 Volume: 47(12) Pages: 1171-1175
• [Journal Article] 専門医のための疾患・外傷診療ガイド 変形性膝関節症(特発性骨壊死を含む) (2012)
  • Author(s): 齋藤知行, 熊谷研
  • Journal Title: 関節外科 10 月増刊号 Volume: 31 Pages: 266-271
• [Journal Article] Low-intensity pulsed ultrasound accelerates fracture healing by stimulation of recruitment of both local and circulating osteogenic progenitors. (2012)
  • Author(s): Kumagai K, Takeuchi R, Ishikawa H, Yamaguchi Y, Fujisawa T, Kuniya T, Takagawa S, Muschler GF, Saito T.
  • Journal Title: J Orthop Res Volume: 30 Issue: 9 Pages: 1516-21
  • DOI: 10.1002/jor.22103
  • Peer Reviewed
• [Journal Article] The extent of degeneration of cruciate ligament is associated with chondrogenic differentiation in patients with osteoarthritis of the knee. (2012)
  • Author(s): Kumagai K, Sakai K, Kusayama Y, Akamatsu Y, Sakamaki K, Morita S, Sasaki T, Saito T, Sakai T.
  • Journal Title: Osteoarthritis Cartilage Volume: 20 Issue: 11 Pages: 1258-67
  • DOI: 10.1016/j.joca.2012.07.013
  • Peer Reviewed
• [Journal Article] 整形外科疾患の保weeks weeks 存療法 手術入院までどんな治療を受けてきたのか? (第12回) 大腿骨顆部骨壊死症 (2011)
  • Author(s): 熊谷研, 齋藤知行
  • Journal Title: 整形外科看護 Volume: 16(1) Pages: 67-71
• [Journal Article] 変形性膝関節症に対する人工骨を用いた小侵襲 opening wedge high tibial osteotomy (2011)
  • Author(s): 齋藤知行, 熊谷研, 藤原豊, 草山喜洋, 赤松泰
  • Journal Title: 整形外科 Volume: 62(8) Pages: 893-897
• [Presentation] 生物学的製剤投与下関節リウマチ患者骨組織における TNF-αおよび IL-6 発現の免疫組織学的評価 (2012)
  • Author(s): 熊谷研,稲葉裕,松尾光祐,針金健吾,雪澤洋平,草山喜洋,長岡亜紀子,藤崎真理,齋藤知行
  • Organizer: 第27回日本整形外科学会基礎学術集会
  • Place of Presentation: 名古屋国際会議場(愛知県)
• [Presentation] Histological abnormality of subchondral structure in spontaneous osteonecrosis of the knee (2012)
  • Author(s): Kumagai K, Akamatsu Y, Kobayashi H, Kusayama Y, Ishigatsubo R, Muramatsu S, Koshino T, Saito T
  • Organizer: 7th Congress of the Asia Pacific Knee Society (APKS)
  • Place of Presentation: New Delhi, India
• [Presentation] クリティカルパスによる Opening wedge HTO 術後療法期間の短縮 (2012)
  • Author(s): 熊谷研,赤松泰,藤原豊,草山喜洋,大澤克成,渡邉太,齋藤知行
  • Organizer: 第4回日本関節鏡・膝・スポーツ整形外科学会
  • Place of Presentation: 沖縄コンベンションセンター(沖縄県)
• [Presentation] Effect of total knee arthroplasty with capsulosynovectomy on disease activity in rheumatoid arthritis patients treated with biological therapy (2012)
  • Author(s): Kumagai K, Kusayama Y, Inaba Y, Matsuo K, Harigane K, Yukizawa Y, Kubota A, Muramatsu S, Nagaoka A, Fujisaki M, Saito T
  • Organizer: The 22nd Japanese-Korean Combined Orthopaedic Symposium
  • Place of Presentation: Nikko Senhime Monogatari Inn, Tochigi, Japan
• [Presentation] 中等度以上の疾患活動性を有する生物学的製剤投与関節リウマチ患者に対する滑膜切除を併用した人工膝関節置換術が疾患活動性に及ぼす影響 (2012)
  • Author(s): 熊谷研, 稲葉裕, 松尾光祐,藤原豊,雪澤洋平,草山喜洋,鈴木宙,富岡政光,長岡亜紀子,藤崎真理,齋藤知行
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京都)
• [Presentation] Abnormal subchondral structure and osteocyte viability in spontaneous osteonecrosis of the knee (2011)
  • Author(s): Kumagai K, Takeuchi R, Ishikawa H, Yamaguchi Y, Fujisawa T, Kuniya T, Koshino T, Saito T
  • Organizer: 8th Biennial ISAKOS Congress
  • Place of Presentation: Rio de Janeiro, Brazil
• [Book] 変形性膝関節症による痛み;治療の実際. 運動器の痛みプライマリケア 膝・大腿部の痛み (2012)
  • Author(s): 熊谷研, 齋藤知行
  • Publisher: 南江堂
• [Book] IV 章 局所的合併症-下肢 12. 膝関節骨切り術. 整形外科 治療と手術の合併症 (2011)
  • Author(s): 齋藤知行, 石川博之, 熊谷研
  • Publisher: 金原出版
• [Book] 変形性膝関節症, リウマチ膝の手術 高位脛骨骨切り術. 整形外科手術イラストレイテッド 膝関節の手術 (2011)
  • Author(s): 齋藤知行, 熊谷研
  • Publisher: 中山書店