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Homing of circulating osteogenic progenitors to fracture healing site by administration of parathyroid hormone

Research Project

Project/Area Number 23791652
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionYokohama City University

Principal Investigator

KUMAGAI Ken  横浜市立大学, 医学部, 助教 (10468176)

Research Collaborator GEORGE F Muschler  Cleveland Clinic, Orthopaedic Research Center, Director
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsPTH / 骨折治癒 / 骨前駆細胞 / ホーミング
Research Abstract

This study demonstrated that bone formation was stimulated through the homing of circulating osteogenic cells by the intermittent administration of parathyroid hormone in mouse femur fracture model. The data also suggested that SDF-1/CXCR4 contributed to the homing of the circulating osteogenic cells.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 4 results) Presentation (6 results) Book (3 results)

  • [Journal Article] The extent of degeneration of cruciate ligament is associated with chondrogenic differentiation in patients with osteoarthritis of the knee2012

    • Author(s)
      Kumagai K, Sakai K, Kusayama Y, Akamatsu Y, Sakamaki K, Morita S, Sasaki T, Saito T, Sakai T
    • Journal Title

      Osteoarthritis Cartilage

      Volume: 20(11) Pages: 1258-67

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Low-intensity pulsed ultrasound accelerates fracture healing by stimulation of recruitment of both local and circulating osteogenic progenitors2012

    • Author(s)
      Kumagai K, Takeuchi R, Ishikawa H, Yamaguchi Y, Fujisawa T, Kuniya T, Takagawa S, Muschler GF, Saito T
    • Journal Title

      J Orthop Res

      Volume: 30(9) Pages: 1516-21

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 誌上シンポジウム 高位脛骨骨切り術の適応と限界 Opening wedge 法2012

    • Author(s)
      熊谷研, 齋藤知行
    • Journal Title

      臨床整形外科

      Volume: 47(12) Pages: 1171-1175

    • Related Report
      2012 Final Research Report
  • [Journal Article] 専門医のための疾患・外傷診療ガイド 変形性膝関節症(特発性骨壊死を含む)2012

    • Author(s)
      齋藤知行, 熊谷研
    • Journal Title

      関節外科 10 月増刊号

      Volume: 31 Pages: 266-271

    • Related Report
      2012 Final Research Report
  • [Journal Article] Low-intensity pulsed ultrasound accelerates fracture healing by stimulation of recruitment of both local and circulating osteogenic progenitors.2012

    • Author(s)
      Kumagai K, Takeuchi R, Ishikawa H, Yamaguchi Y, Fujisawa T, Kuniya T, Takagawa S, Muschler GF, Saito T.
    • Journal Title

      J Orthop Res

      Volume: 30 Issue: 9 Pages: 1516-21

    • DOI

      10.1002/jor.22103

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The extent of degeneration of cruciate ligament is associated with chondrogenic differentiation in patients with osteoarthritis of the knee.2012

    • Author(s)
      Kumagai K, Sakai K, Kusayama Y, Akamatsu Y, Sakamaki K, Morita S, Sasaki T, Saito T, Sakai T.
    • Journal Title

      Osteoarthritis Cartilage

      Volume: 20 Issue: 11 Pages: 1258-67

    • DOI

      10.1016/j.joca.2012.07.013

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 整形外科疾患の保weeks weeks 存療法 手術入院までどんな治療を受けてきたのか? (第12回) 大腿骨顆部骨壊死症2011

    • Author(s)
      熊谷研, 齋藤知行
    • Journal Title

      整形外科看護

      Volume: 16(1) Pages: 67-71

    • Related Report
      2012 Final Research Report
  • [Journal Article] 変形性膝関節症に対する人工骨を用いた小侵襲 opening wedge high tibial osteotomy2011

    • Author(s)
      齋藤知行, 熊谷研, 藤原豊, 草山喜洋, 赤松泰
    • Journal Title

      整形外科

      Volume: 62(8) Pages: 893-897

    • Related Report
      2012 Final Research Report
  • [Presentation] 生物学的製剤投与下関節リウマチ患者骨組織における TNF-αおよび IL-6 発現の免疫組織学的評価2012

    • Author(s)
      熊谷研,稲葉裕,松尾光祐,針金健吾,雪澤洋平,草山喜洋,長岡亜紀子,藤崎真理,齋藤知行
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Final Research Report
  • [Presentation] Histological abnormality of subchondral structure in spontaneous osteonecrosis of the knee2012

    • Author(s)
      Kumagai K, Akamatsu Y, Kobayashi H, Kusayama Y, Ishigatsubo R, Muramatsu S, Koshino T, Saito T
    • Organizer
      7th Congress of the Asia Pacific Knee Society (APKS)
    • Place of Presentation
      New Delhi, India
    • Related Report
      2012 Final Research Report
  • [Presentation] クリティカルパスによる Opening wedge HTO 術後療法期間の短縮2012

    • Author(s)
      熊谷研,赤松泰,藤原豊,草山喜洋,大澤克成,渡邉太,齋藤知行
    • Organizer
      第4回日本関節鏡・膝・スポーツ整形外科学会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県)
    • Related Report
      2012 Final Research Report
  • [Presentation] Effect of total knee arthroplasty with capsulosynovectomy on disease activity in rheumatoid arthritis patients treated with biological therapy2012

    • Author(s)
      Kumagai K, Kusayama Y, Inaba Y, Matsuo K, Harigane K, Yukizawa Y, Kubota A, Muramatsu S, Nagaoka A, Fujisaki M, Saito T
    • Organizer
      The 22nd Japanese-Korean Combined Orthopaedic Symposium
    • Place of Presentation
      Nikko Senhime Monogatari Inn, Tochigi, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] 中等度以上の疾患活動性を有する生物学的製剤投与関節リウマチ患者に対する滑膜切除を併用した人工膝関節置換術が疾患活動性に及ぼす影響2012

    • Author(s)
      熊谷研, 稲葉裕, 松尾光祐,藤原豊,雪澤洋平,草山喜洋,鈴木宙,富岡政光,長岡亜紀子,藤崎真理,齋藤知行
    • Organizer
      第56回日本リウマチ学会総会・学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Related Report
      2012 Final Research Report
  • [Presentation] Abnormal subchondral structure and osteocyte viability in spontaneous osteonecrosis of the knee2011

    • Author(s)
      Kumagai K, Takeuchi R, Ishikawa H, Yamaguchi Y, Fujisawa T, Kuniya T, Koshino T, Saito T
    • Organizer
      8th Biennial ISAKOS Congress
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Related Report
      2012 Final Research Report
  • [Book] 変形性膝関節症による痛み;治療の実際. 運動器の痛みプライマリケア 膝・大腿部の痛み2012

    • Author(s)
      熊谷研, 齋藤知行
    • Publisher
      南江堂
    • Related Report
      2012 Final Research Report
  • [Book] IV 章 局所的合併症-下肢 12. 膝関節骨切り術. 整形外科 治療と手術の合併症2011

    • Author(s)
      齋藤知行, 石川博之, 熊谷研
    • Publisher
      金原出版
    • Related Report
      2012 Final Research Report
  • [Book] 変形性膝関節症, リウマチ膝の手術 高位脛骨骨切り術. 整形外科手術イラストレイテッド 膝関節の手術2011

    • Author(s)
      齋藤知行, 熊谷研
    • Publisher
      中山書店
    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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