| Project/Area Number |
23791655
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
HISAOKA Tomoko 和歌山県立医科大学, 医学部, 助教 (00398463)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 再生医学 / 脊髄損傷 / サイトカイン / グリア瘢痕 / 嗅神経被覆グリア |
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| Research Abstract |
First, we investigated the expression pattern of TROY in thedeveloping and adult spinal cord. TROY was expressed in the nestin-positive,GLAST-negative neural progenitor/radial glial cells in the spinal cord during embryonicstages. During postnatal stages, TROY was exclusively expressed in the GFAP- orS100-positive astrocytes in the spinal cord. Next, we investigated the expression ofTROY in the spinal cord after dorsal hemisection of the spinal cord. A few TROY-positivecells were observed around the injury site. These results suggest that TROY may beinvolved in the development of dorsal subpopulation of neural progenitor/radial glialcells and astrocytes in the spinal cord.
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