The integrated search of mesenchymal stem cell fate determination of differentiation controlled by micro RNAs
| Project/Area Number |
23791657
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Saitama Medical University |
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Principal Investigator |
MIZUNO Yosuke 埼玉医科大学, 医学部, 助教 (30406532)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨・軟骨代謝学 / 非コードRNA / 転写制御 / 細胞分化 / マイクロRNA |
|---|
| Research Abstract |
In this study, we identified a microRNA which are transcriptionally regulated by the transcription factor osterix that have critical roles for osteoblast differentiation. We identified that this micro RNA targets the genes which promote osteoblast differentiation and inhibit their function, and transcription of this micro RNA itself is negatively regulated by osterix. Moreover, we also found that this micro RNA negatively regulates osteoblast differentiation. Therefore, in this study we found a micro RNA that could regulate the fate of mesenchymal stem cells for osteoblast differentiation. This finding further contributes the understanding of pathogenic mechanisms with micro RNAs to the life-style diseases such as osteoporosis and obesity.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Identification of Ccr4-Not complex components as regulators of transition from partial to genuine induced pluripotent stem cells2013
Author(s)
Masayoshi Kamon, Miyuki Katano, Keiko Hiraki-Kamon, Tomoaki Hishida, Yutaka Nakachi, Yosuke Mizuno, Yasushi Okazaki, Ayumu Suzuki, Masataka Hirasaki, Atsushi Ueda, Masazumi Nishimoto, Hidemasa Kato, Akihiko Okuda
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Journal Title
Stem Cells Dev
Volume: (Epub ahead of print)
Related Report
Peer Reviewed
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[Journal Article] Sirt1, p53, and p38 (MAPK) Are Crucial Regulators of Detrimental Phenotypes of Embryonic Stem Cells with Max Expression Ablation2012
Author(s)
Tomoaki Hishida, Yuriko Nozaki, Yutaka Nakachi, Yosuke Mizuno, Hiroyoshi Iseki, Miyuki Katano, Masayoshi Kamon, Masataka Hirasaki, Masazumi Nishimoto, Yasushi Okazaki, Akihiko Okuda
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Journal Title
Stem Cells
Volume: Vol. 30, No. 8
Pages: 1634-1644
Related Report
Peer Reviewed
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