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The integrated search of mesenchymal stem cell fate determination of differentiation controlled by micro RNAs

Research Project

Project/Area Number 23791657
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionSaitama Medical University

Principal Investigator

MIZUNO Yosuke  埼玉医科大学, 医学部, 助教 (30406532)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords骨・軟骨代謝学 / 非コードRNA / 転写制御 / 細胞分化 / マイクロRNA
Research Abstract

In this study, we identified a microRNA which are transcriptionally regulated by the transcription factor osterix that have critical roles for osteoblast differentiation. We identified that this micro RNA targets the genes which promote osteoblast differentiation and inhibit their function, and transcription of this micro RNA itself is negatively regulated by osterix. Moreover, we also found that this micro RNA negatively regulates osteoblast differentiation. Therefore, in this study we found a micro RNA that could regulate the fate of mesenchymal stem cells for osteoblast differentiation. This finding further contributes the understanding of pathogenic mechanisms with micro RNAs to the life-style diseases such as osteoporosis and obesity.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (18 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (15 results)

  • [Journal Article] Identification of Ccr4-Not complex components as regulators of transition from partial to genuine induced pluripotent stem cells2013

    • Author(s)
      Masayoshi Kamon, Miyuki Katano, Keiko Hiraki-Kamon, Tomoaki Hishida, Yutaka Nakachi, Yosuke Mizuno, Yasushi Okazaki, Ayumu Suzuki, Masataka Hirasaki, Atsushi Ueda, Masazumi Nishimoto, Hidemasa Kato, Akihiko Okuda
    • Journal Title

      Stem Cells Dev

      Volume: (Epub ahead of print)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sirt1, p53, and p38 (MAPK) Are Crucial Regulators of Detrimental Phenotypes of Embryonic Stem Cells with Max Expression Ablation2012

    • Author(s)
      Tomoaki Hishida, Yuriko Nozaki, Yutaka Nakachi, Yosuke Mizuno, Hiroyoshi Iseki, Miyuki Katano, Masayoshi Kamon, Masataka Hirasaki, Masazumi Nishimoto, Yasushi Okazaki, Akihiko Okuda
    • Journal Title

      Stem Cells

      Volume: Vol. 30, No. 8 Pages: 1634-1644

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Indefinite Self-Renewal of ESCs through Myc/Max Transcriptional Complex-Independent Mechanisms2011

    • Author(s)
      Tomoaki Hishida, Yuriko Nozaki, Yutaka Nakachi, Yosuke Mizuno, Yasushi Okazaki, Masatsugu Ema, Satoru Takahashi, Masazumi Nishimoto, Akihiko Okuda
    • Journal Title

      Cell Stem Cell

      Volume: Vol. 9, No. 1 Pages: 37-49

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 間葉系幹細胞分化を調節するキー転写因子による、マイクロRNAを介した細胞分化制御2013

    • Author(s)
      水野洋介、仲地豊、徳澤佳美、兼先-八塚由紀子、岡崎康司
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸市
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 脂肪・骨芽細胞分化を制御する非コードRNAの探索2013

    • Author(s)
      水野洋介、仲地豊、徳澤佳美、八塚由紀子、岡崎康司
    • Organizer
      NGS現場の会第三回研究会
    • Place of Presentation
      神戸市
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Regulation of Adipocyte/Osteoblast Differentiation by microRNAs That Are Controlled by Master Regulatory Transcription Factors2013

    • Author(s)
      Yosuke Mizuno, Yutaka Nakachi, Yoshimi Tokuzawa, Yukiko Kanesaki-Yatsuka, Yasushi Okazaki
    • Organizer
      Keystone Symposia 2013, RNA Silencing
    • Place of Presentation
      Whistler, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] CAGELOH (CAGE Loci Oriented Heatmap) によるマウス間葉系幹細胞の脂肪細胞・骨芽細胞分化トランスクリプトーム統合解析2013

    • Author(s)
      仲地豊、水野洋介、徳澤佳美、山下泉、八塚由紀子、岡崎康司
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 間葉系幹細胞分化のマスターレギュレーター転写因子による、マイクロRNAを介した細胞分化制御2012

    • Author(s)
      水野洋介,仲地豊,徳澤佳美,兼先-八塚由紀子,岡崎康司
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      神戸市
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of differentiation via microRNAs controlled by master regulator transcription factors during adipocyte/osteoblast differentiation2012

    • Author(s)
      Yosuke Mizuno, Yutaka Nakachi, Yoshimi Tokuzawa, Yukiko Yatsuka, Yasushi Okazaki
    • Organizer
      生命医薬情報学連合大会
    • Place of Presentation
      東京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 間葉系幹細胞分化のマスターレギュレーター転写因子による、マイクロRNAを介した細胞分化制御2012

    • Author(s)
      水野洋介、仲地豊、徳澤佳美、八塚由紀子、岡崎康司
    • Organizer
      第14回日本RNA学会年会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of differentiation via microRNAs controlled by master regulator transcription factors during adipocyte/osteoblast differentiation2011

    • Author(s)
      Yosuke Mizuno, Yutaka Nakachi, Yoshimi Tokuzawa, Yukiko Kanesaki-Yatsuka, Yasushi Okazaki
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Final Research Report
  • [Presentation] The regulation of miRNA transcription by transcription factors involved in differentiation of mesenchymal stem cells2011

    • Author(s)
      Yosuke Mizuno, Yutaka Nakachi, Yoshimi Tokuzawa, Yukiko Yatsuka, Yasushi Okazaki
    • Organizer
      RNA2011
    • Place of Presentation
      京都市
    • Related Report
      2013 Final Research Report
  • [Presentation] 間葉系幹細胞分化のマスターレギュレーター転写因子による、マイクロRNAを介した細胞分化制御

    • Author(s)
      水野 洋介、仲地 豊、徳澤 佳美、八塚 由紀子、岡崎 康司
    • Organizer
      第14回 日本RNA学会年会
    • Place of Presentation
      東北大学百周年記念会館川内萩ホール(宮城県仙台市)
    • Related Report
      2012 Research-status Report
  • [Presentation] Regulation of differentiation via microRNAs controlled by master regulator transcription factors during adipocyte/osteoblast differentiation

    • Author(s)
      Yosuke Mizuno, Yutaka Nakachi, Yoshimi Tokuzawa, Yukiko Yatsuka, Yasushi Okazaki
    • Organizer
      生命医薬情報学連合大会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Related Report
      2012 Research-status Report
  • [Presentation] 間葉系幹細胞分化のマスターレギュレーター転写因子による、マイクロRNAを介した細胞分化制御

    • Author(s)
      水野 洋介, 仲地 豊, 徳澤 佳美, 兼先-八塚 由紀子, 岡崎 康司
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡(福岡県福岡市)
    • Related Report
      2012 Research-status Report
  • [Presentation] Regulation of Adipocyte/Osteoblast Differentiation by microRNAs That Are Controlled by Master Regulatory Transcription Factors

    • Author(s)
      Yosuke Mizuno, Yutaka Nakachi, Yoshimi Tokuzawa, Yukiko Kanesaki-Yatsuka, Yasushi Okazaki
    • Organizer
      Keystone Symposia 2013, RNA Silencing
    • Place of Presentation
      Whistler Conference Centre (Whistler, British Columbia, Canada)
    • Related Report
      2012 Research-status Report
  • [Presentation] 間葉系幹細胞の分化を制御する転写因子によるマイクロRNAの調節

    • Author(s)
      水野 洋介、仲地 豊、徳澤 佳美、八塚由紀子 、岡崎 康司
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Related Report
      2011 Research-status Report
  • [Presentation] The regulation of miRNA transcription by transcription factors involved in differentiation of mesenchymal stem cells

    • Author(s)
      水野 洋介、仲地 豊、徳澤 佳美、八塚由紀子 、岡崎 康司
    • Organizer
      RNA2011
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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