The analysis of the effect of novel agent for bone metabolism on bone metastasis
| Project/Area Number |
23791668
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
MAEDA Kazuhiro 東京慈恵会医科大学, 医学部, 助教 (50548849)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Wntシグナル / 転移性骨腫瘍 / Ｗｎｔシグナル / 破骨細胞 / Wnt |
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| Research Abstract |
RANK is a receptor of RANKL which is an essential molecule for osteoclastogenesis. Previously, we reported that the Wnt5a-Ror2 pathway enhances the expression of RANK in macrophages. On the other hand, another group reported that the expression of RANK in tumor cells enhance bone metastasis. Taken together, these findings suggest that the Wnt expressed by tumor cells affects itself in an autocrine manner, and promotes bone metastasis through the induction of RANK expression.
To test this hypothesis, we performed experiments using cell lines which have affinity for the bone such as breast and prostate cancer cell lines. In results these cells highly expressed RANK, Wnt5a and Ror1/2 in comparison with control cells. These results indicate that Wnt5a expressed by tumor cells act on Ror2 expressed in itself in an autocrine manner, and enhanced bone metastasis through the induction of RANK expression in tumor cells.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Noncanonical Wnt5a enhances Wnt/-catenin signaling during osteogenesis.2014
Author(s)
Okamoto, M., Udagawa, N., Yamashita, T., Nakamichi, Y., Uehara, S., Kato, H., Saito, N., Minami, Y., Takahashi, N., Kobayashi, Y.
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Journal Title
Sci. report
Volume: 4
Issue: 1
Pages: 4493-4493
DOI
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Peer Reviewed / Open Access
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[Journal Article] Wnt5a-Ror2 signaling between osteoblasts and osteoclast precursors enhances osteoclastogenesis2012
Author(s)
Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., Nishita, M., Marumo, K., Martin, T.J., Minami, Y., Takahashi, N.
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Journal Title
Nat.Med.
Volume: (印刷中)
Issue: 3
Pages: 405-12
DOI
Related Report
Peer Reviewed
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[Presentation] Wnt非古典経路はRANKの発現を亢進し破骨細胞分化を促進する2011
Author(s)
前田和洋,小林泰浩,岡本正則,高田伊知郎,加藤茂明,可児修一,西田満,南康博,宇田川信之,丸毛啓史,高橋直之
Organizer
第26回日本整形外科学会基礎学術集会
Place of Presentation
前橋
Year and Date
2011-10-20
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