Detection of specific antibody in patients with rheumatoid arthritis negative for anti-CCP antibody

• Project/Area Number: 23791669
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Keio University (2012); Tokyo Women's Medical University (2011)
• Principal Investigator: IWAMOTO Takuji 慶應義塾大学, 医学部, 助教 (10348675)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 関節リウマチ / 自己抗体 / 抗CCP抗体 / プロテインマイクロアレイ

Research Abstract

Rheumatoid arthritis is an autoimmune disease characterized by polyarthritis leading to progressive joint destruction. The purpose of this study is to detect the specific autoantibody in RA patients. We examined the serum autoantibodies for over 9,000 hum