| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
The high prevalence and variability of familial idiopathic scoliosis is indicative of genetic heterogeneity. To localize genes related to scoliosis, groups of families with common clinical characteristics have been identified in an attempt to reduce genetic heterogeneity. Recent work has provided evidence that adolescent idiopathic scoliosis is linked to several different loci; however, the limited number of microsatellite makers used in the study made the linkage analysis less efficient.The aim of this study was to identify the genomic locus of familial idiopathic scoliosis. We identified five SNPs in four genes in three previously reported candidate genomic loci thought to be responsible for the development of idiopathic scoliosis. The candidate genes exhibited the strongest evidence for linkage in all of the analyses considered. All of the candidate genes have been identified as essential for skeletal and axonal growth.
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