Strategy for enhancing axonal regeneration after spinal cord injury
Project/Area Number |
23791677
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | National Hospital Organization Murayama Medical Center |
Principal Investigator |
KANEKO Shinjiro 独立行政法人国立病院機構村山医療センター(臨床研究センター), 整形外科, 医長 (10327554)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 脊椎脊髄病学 / 脊髄損傷 |
Research Abstract |
Rats exhibit extremely limited motor function recovery after total transection of the spinal cord (SCT). We previously reported that a semaphorin3A inhibitor (SI) enhanced axon regeneration and motor function recovery in SCT. However, these effects were limited because most regenerated axons likely do not connect to the right targets. Thus, rebuilding the appropriate connections for regenerated axons may enhance recovery. In this study, we combined SI treatment with treadmill training to determine whether combined treatment would further enhance the "rewiring" of regenerated axons. Although combined treatment did not further improve axon regeneration, hindlimb motor performance was restored, as evidenced by the significant improvement in the execution of plantar steps on a treadmill. This study highlights the importance of combining treatment that promote axon regeneration with specific and appropriate rehabilitations that promote rewiring for the treatment of spinal cord injury.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] Association of Postoperative Shoulder Balance With Adding-on in Lenke Type II Adolescent Idiopathic Scoliosis2014
Author(s)
Cao K, Watanabe K, Hosogane N, Toyama Y, Yonezawa I, Machida M, Yagi M, Kaneko S, Kawakami N, Tsuji T, Matsumoto M
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Journal Title
Spine (Phila Pa 1976)
Volume: 39(12)
Issue: 12
Pages: E705-E712
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[Journal Article] Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibition2014
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Zhang L, Kaneko S, Kikuchi K, Sano A, Maeda M, Kishino A, Shibata S, Mukaino M, Toyama Y, Liu M, Kimura T, Okano H, Nakamura M
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Molecular Brain
Volume: 7
Issue: 1
Pages: 14-14
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[Journal Article] Selection of lower instrumented vertebra in treating Lenke type 2A adolescent idiopathic scoliosis2014
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Cao K, Watanabe K, Kawakami N, Tsuji T, Hosogane N, Yonezawa I, Machida M, Yagi M, Kaneko S, Toyama Y, Matsumoto M
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Spine (Phila Pa 1976)
Volume: 39(4)
Issue: 4
Pages: E253-E261
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[Journal Article] 図説脊椎・脊髄疾患シリーズ№10脊柱後弯症2012
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金子慎二郎,町田正文,塩田匡宣,竹光正和,八木満,藤吉兼浩,飯塚慎吾,名越慈人,三宅敦,長谷川淳,臼井宏
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IRYO
Volume: 66(10)
Pages: 575-584
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[Journal Article] 図説脊椎・脊髄疾患シリーズ№4脊髄腫瘍と脊椎腫瘍2012
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金子慎二郎,町田正文,塩田匡宣,竹光正和,福田健太郎,八木満,藤吉兼浩,飯塚慎吾,名越慈人,長谷川淳,臼井宏
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IRYO
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金子慎二郎, 塩田匡宣, 臼井宏, 中村雅也, 戸山芳昭, 松本守雄
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[Journal Article] 脊髄腫瘍と脊椎腫瘍2012
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金子慎二郎, 町田正文, 塩田匡宣, 竹光正和, 福田健太郎, 八木満, 藤吉兼浩, 飯塚慎吾, 名越慈人, 長谷川淳, 臼井宏
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[Presentation] 成人脊柱変形に対する手術前casting testの有効性に関する検討2013
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金子慎二郎,町田正文,竹光正和,八木満,藤吉兼浩,飯塚慎吾,名越慈人,三宅敦,長谷川淳,塩田匡宣,朝妻孝仁
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第3回日本成人脊柱変形学会
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東京
Year and Date
2013-03-03
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[Presentation] 成人脊柱変形に対する術前simulationとしてのcasting testの有効性に関する検討2013
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第67回国立病院総合医学会
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第42回日本脊椎脊髄病学会
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[Presentation] 成人脊柱変形に対する手術前simulationとしてのcasting testの有効性に関する検討2013
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第42回日本脊椎脊髄病学会
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第66回国立病院総合医学会
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第66回国立病院総合医学会
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第66回国立病院総合医学会
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第41回日本脊椎脊髄病学会
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第65回国立病院総合医学会
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