| Project/Area Number |
23791677
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | National Hospital Organization Murayama Medical Center |
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Principal Investigator |
KANEKO Shinjiro 独立行政法人国立病院機構村山医療センター(臨床研究センター), 整形外科, 医長 (10327554)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 脊椎脊髄病学 / 脊髄損傷 |
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| Research Abstract |
Rats exhibit extremely limited motor function recovery after total transection of the spinal cord (SCT). We previously reported that a semaphorin3A inhibitor (SI) enhanced axon regeneration and motor function recovery in SCT. However, these effects were limited because most regenerated axons likely do not connect to the right targets. Thus, rebuilding the appropriate connections for regenerated axons may enhance recovery. In this study, we combined SI treatment with treadmill training to determine whether combined treatment would further enhance the "rewiring" of regenerated axons. Although combined treatment did not further improve axon regeneration, hindlimb motor performance was restored, as evidenced by the significant improvement in the execution of plantar steps on a treadmill. This study highlights the importance of combining treatment that promote axon regeneration with specific and appropriate rehabilitations that promote rewiring for the treatment of spinal cord injury.
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