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Effects of an oral pre-administered beta-blocker on cardiopulmonary resuscitation in various cardiac arrests

Research Project

Project/Area Number 23791690
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Anesthesiology/Resuscitation studies
Research InstitutionKanazawa University

Principal Investigator

KURITA AKIHIDE  金沢大学, 大学病院, 助教 (10507081)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsβ遮断薬
Research Abstract

The present studies were performed to evaluate effects of a beta-blocker on cardiac arrests induced by severe hemorrhagic shock and airway obstruction in rats, and on endotoxic shock induced by endotoxin, and on septic shock induced by cecal ligation and punctures in rats. (1) Administration of a beta-blocker on cardiac arrests induced by severe hemorrhagic shock deteriorated prognosis. (2) Administration of a beta-blocker on cardiac arrests induced by airway obstruction in rats improved recovery rate from cardiac arrests. (3) Administration of a beta-blocker on endotoxic shock induced by endotoxin deteriorated prognosis. (4) Administration of a beta-blocker on septic shock induced by cecal ligation and punctures in rats gave no influences on motality.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (7 results)

All 2014 2011

All Presentation (7 results)

  • [Presentation] ラット盲腸結紮穿刺モデルにおける内服カルベジロールの影響2014

    • Author(s)
      結城緑,栗田昭英
    • Organizer
      日本麻酔科学会総会
    • Place of Presentation
      横浜,日本
    • Year and Date
      2014-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of oral administration of carvedilol on Verotoxin induced HUS model in rats2014

    • Author(s)
      Akihide Kurita
    • Organizer
      Society of Critical Care Medicine
    • Place of Presentation
      San Francisco, California, USA
    • Year and Date
      2014-01-10
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット盲腸結紮穿刺敗血症モデルにおける内服カルベジロールの影響2014

    • Author(s)
      結城 緑,栗田昭英,谷口 巧,山本剛史,山本 健
    • Organizer
      日本麻酔科学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of oral administration of Carvedilol on verotoxin induced HUS model in rats2014

    • Author(s)
      Akihide Kurita, Midori Yuki, Takumi Taniguchi, Takashi Yamamoto, Ken Yamamoto
    • Organizer
      Society of Critical Care Medicine
    • Place of Presentation
      San Francisco, California, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Disadvantage effects of Carvedilol on mortality and inflammatory responses to endotoxin-induced shock in rats2011

    • Author(s)
      Koji Sato, Akihide Kurita
    • Organizer
      American Heart Association's Resuscitation Science Symposium
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2011-11-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Beneficial effects of the high dose atorvastatin on mortality and inflammatory responses to severe hemorrhagic shock in rats2011

    • Author(s)
      Akihide Kurita
    • Organizer
      American Heart Association's Resuscitation Science Symposium
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2011-11-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Beneficial effects of the high dose atorvastatin on mortality and inflammatory responses to severe hemorrhagic shock in rats2011

    • Author(s)
      Akihide Kurita
    • Organizer
      American Heart Association’s Resuscitation Science Symposium
    • Place of Presentation
      orange county convention center, Orlando, USA
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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