Research on descending pain control mechanism
Project/Area Number |
23791693
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Anesthesiology/Resuscitation studies
|
Research Institution | Shinshu University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 下行性抑制系 / ノルアドレナリン / 青斑核 / 下行性痛み抑制系 / in vivoパッチクランプ |
Research Abstract |
To address the cellular mechanisms underlying pain modulation we have developed a patch-clamp recording technique from LC neurones in anaesthetized rats. These recordings showed LC discharge in vivo to be driven by both spontaneous membrane potentialoscillations. This approach allows detailed characterisation of the synaptic and integrative mechanisms of LC responses to naturalistic stimulation.
|
Report
(3 results)
Research Products
(6 results)