Molecular biological analysis about the effect of general anesthetics on the induction of erythropoietin in the brain

Research Project

Project/Area Number	23791703
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Kyoto University
Principal Investigator	TANAKA Tomoharu 京都大学, 医学(系)研究科(研究院), 助教 (10402893)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords	麻酔学 / 脳内エリスロポエチン / 低酸素 / 麻酔薬 / エリスロポエチン / グリア細胞
Research Abstract	Erythropoietin is endogenously expressed in the central nervous system (CNS). EPO in the CNS, mainly produced in astrocytes. We investigated the effect of general anesthetics on EPO expression in the mouse brain and primary cultured astrocytes.We found the common inhibitory effect of the general anesthetics against hypoxia-induced EPO upregulation in the mouse brain through a direct effect on astrocytes.