Analysis of effects of anesthetic agent on rat somatosensory cortexusing in vivo patch clamp recording

• Project/Area Number: 23791710
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kyushu University
• Principal Investigator: SHIOKAWA Hiroaki 九州大学, 大学院・医学研究院・麻酔蘇生学, 助教 (30572490)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
• Keywords: 疼痛管理学 / インビボパッチクランプ / 大脳皮質 / 第一次体性感覚野 / oscillation / プロポフォール / ペントバルビタール / レミフェンタニル / ケタミン / インビボパッチクランプ記録

Research Abstract

In this project, in vivo whole-cell patch-clamp recordings were performed from primary somatosensoryneurons which responded to the mechanical stimuli to the receptive field of the hind paw area.Propofol, pentobarbital, remifentanil or ketaminewas administered intravenously to the rat after starting recordings. We evaluated the effect of these anesthetic agents by analyzing the responses evoked by pinch stimuli

Research Products

• [Presentation] Analysis of analgesic effect of propofol by in-vivo patch clamp recordings from the somatosensory cortex of rats (2012)
  • Author(s): 塩川 浩輝、山浦 健、辛島 裕士、外須美夫
  • Organizer: nnual Meeting of the American Society of Anesthesiologists
  • Place of Presentation: 米国、ワシントンD.C.
  • Year and Date: 2012-10-14
• [Presentation] Analysis of analgesic effect of propofol by in-vivo patch clamp recordings from the somatosensory cortex of rats (2012)
  • Author(s): 塩川 浩輝、古賀 公平、山浦 健、辛島裕士、外 須美夫
  • Organizer: European Society of Anesthesiology annual meeting, Euroanaesthesia 2012
  • Place of Presentation: フランス、パリ
  • Year and Date: 2012-06-10
• [Presentation] Analysis of analgesic effect of propofol by in-vivo patch clamp recordings from the somatosensory cortex of rats (2012)
  • Author(s): 塩川 浩輝
  • Organizer: European Society of Anesthesiology annual meeting, Euroanaesthesia 2012
  • Place of Presentation: フランス、パリ
• [Presentation] Analysis of analgesic effect of propofol by in-vivo patch clamp recordings from the somatosensory cortex of rats (2012)
  • Author(s): 塩川 浩輝
  • Organizer: Annual Meeting of the American Society of Anesthesiologists
  • Place of Presentation: 米国、ワシントンD.C.