Development of a new treatment for renal ischemic-reperfusion injury using ETS-GS, a novel vitamin E

• Project/Area Number: 23791716
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Oita University
• Principal Investigator: KUSAKA Junya 大分大学, 医学部, 客員研究員 (00567951)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 腎機能障害 / ビタミンE / グルタチオン / タウリン / 酸化ストレス / 急性障害 / 虚血再灌流 / 抗酸化薬 / ビタミンＥ / 急性腎障害 / 腎虚血再灌流モデル / 腎虚血再灌流 / 急性腎傷害 / 炎症 / ミトコンドリア

Research Abstract

We investigated whether ETS-GS, a novel vitamin E derivative, had therapeutic effect against renal ischemic-reperfusion injury in rat model. In this study, we found that ETS-GS improved the survival retes, renal disfunction after renal ischemic-reperfusion, which was also demonstrated by histological evaluation. In addition, our results indicated that the mechanism of improvement effect against renal ischemic-reperfusion injury may be involved in antioxidant effect by ETS-GS.