Neuroprotection using hydrogen sulfide donors : in the mice primary cultured neurons
| Project/Area Number |
23791718
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
KAMIZATO Kota 琉球大学, 医学部附属病院, 助教 (10554454)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 神経保護 / 硫化水素 / 対麻痺 / 神経細胞保護 |
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| Research Abstract |
Paraplegia is a severe complication after the surgery of thoracic aorta anyrism. But the mechanism is unknown. We performed a study on mechanism of the neuroprotection with hydrogen sulfide after spinal cord ischemia, using the mice primary cultured neurons. We used sodium sulphide and GYY4137 as a hydrogen sulfide donor. However, the effect of neuroprotection for cultured neurons was weak. We seek the protein signals in the neurons with hydrogen sulfide attaching (sodium sulphide and GYY4137) by DNA micro array. However, no significant change was confirmed by DNA micro array.
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Report
(3 results)
Research Products
(2 results)
