| Project/Area Number |
23791722
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagoya City University |
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Principal Investigator |
OTA Haruko 名古屋市立大学, 医学(系)研究科(研究院), 助教 (90534751)
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アルツハイマー型認知症 / 麻酔薬 / 高次脳機能 / アルツハイマー / 高次脳障害 |
|---|
| Research Abstract |
The dementia, e.g. Alzheimer' disease, in the elderly people is increasing in our country every year. As a pathogenic mechanism of Alzheimer' disease, polymerization of beta amyloid (Ab) and Hyper-phosphorylation of Tau protein are known. The increase in Ab production, the increase in GM1ganglioside which changes structure of Ab, control of Ab degradation system are pointed out as mechanisms of Ab accumulation. Anesthesia for such a patient is also increasing. This study demonstrated that propofol and a barbital decrease Ab polymerization in neurons by controlling revelation of GM1, and to control cell death. Moreover, ketamine and droperidol decreased the activity of neprilysin which decomposes Ab, and it became clear to promote accumulation of Ab.
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