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The crosstalk pathway between macrophages and T-lymphocytes involves in neuropathic pain

Research Project

Project/Area Number 23791724
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Anesthesiology/Resuscitation studies
Research InstitutionWakayama Medical University

Principal Investigator

KOBAYASHI Yuka  和歌山県立医科大学, 医学部, 助教 (20511562)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords神経障害性疼痛 / 神経炎症 / マクロファージ / T 細胞 / GITR / GITRL / 慢性疼痛 / T細胞 / 共刺激分子
Research Abstract

The activated immune cells-induced peripheral neuroinflammation contributes to the pathogenesis of neuropathic pain. We investigated the involvement of crosstalk between macrophages and T cells in neuropathic pain. Macrophages and T -lymphocytes infiltrated in the injured sciatic nerve, and they expressed GITRL and GITR which are co-stimulatory molecules. The inhibition of crosstalk alleviated nerve injury-induced neuropathic pain. Threfore, the regulation of neuroinflammtion through a crosstalk between macrophages and T -lymphocytes cells plays a crucial role in neuropathic pain.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (53 results)

All 2013 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 9 results) Presentation (39 results) Remarks (3 results)

  • [Journal Article] The critical role of spinal ceramide in the development of partial sciatic nerve ligation-induced neuropathic pain in mice2012

    • Author(s)
      Kobayashi Y, Kiguchi N, Maeda T et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 421.2 Pages: 318-322

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic augmentation of the MIP-2/CXCR2 axis through histone H3 acetylation in injured peripheral nerves elicits neuropathic pain2012

    • Author(s)
      Kiguchi N, Kobayashi Y, Maeda T et al
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 340.3 Pages: 577-587

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of nicotinic acetylcholine receptors on bone marrow-derived cells relieves neuropathic pain accompanied by peripheral neuroinflamation2012

    • Author(s)
      Kiguchi N, Kobayashi Y, Maeda T et al.
    • Journal Title

      Neurochem Int.

      Volume: 61 Pages: 1212-1219

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] CC-chemokine ligand 4/macrophage inflammatory protein-1β participates in the induction of neuropathic pain after peripheral nerve injury2012

    • Author(s)
      Saika F, Kiguchi N, Kobayashi Y et al
    • Journal Title

      Eur J Pain

      Volume: 16 Pages: 1271-1280

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemokines and cytokines in neuroinflammation leading to neuropathicpain2012

    • Author(s)
      Kiguchi N, Kobayashi Y and Kishioka S
    • Journal Title

      Curr Opin Pharmacol

      Volume: 12.1 Pages: 55-61

    • Related Report
      2012 Final Research Report
  • [Journal Article] The critical role of spinal ceramide in the development of partial sciatic nerve ligation-induced neuropathic pain in mice2012

    • Author(s)
      Kobayashi Y, Kiguchi N, Maeda T, Ozaki M, Kishioka S.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 421 Issue: 2 Pages: 318-322

    • DOI

      10.1016/j.bbrc.2012.03.153

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic augmentation of the macrophage inflammatory protein 2/C-X-C chemokine receptor type 2 axis through histone H3 acetylation in injured peripheral nerves elicits neuropathic pain2012

    • Author(s)
      Kiguchi N, et al
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 340 Issue: 3 Pages: 577-587

    • DOI

      10.1124/jpet.111.187724

    • Related Report
      2012 Annual Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] CC-chemokine ligand 4/macrophage inflammatory protein-1β participates in the induction of neuropathic pain after peripheral nerve injury.2012

    • Author(s)
      Saika F, Kiguchi N, Kobayashi Y, Fukazawa Y, and Kishioka S
    • Journal Title

      Eur J Pain.

      Volume: 16 Issue: 9 Pages: 1271-1280

    • DOI

      10.1002/j.1532-2149.2012.00146.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of nicotinic acetylcholine receptors on bone marrow-derived cells relieves neuropathic pain accompanied by peripheral neuroinflamation.2012

    • Author(s)
      Kiguchi N, Kobayashi Y, Maeda T, Tominaga S, Nakamura J, Fukazawa Y, Ozaki M and Kishioka S
    • Journal Title

      Neurochem Int.

      Volume: 61 Issue: 7 Pages: 1212-1219

    • DOI

      10.1016/j.neuint.2012.09.001

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemokines and cytokines in neuroinflammation leading to neuropathic pain2012

    • Author(s)
      Kiguchi N, et al
    • Journal Title

      Curr Opin Pharmacol

      Volume: 12(invited) Issue: 1 Pages: 55-61

    • DOI

      10.1016/j.coph.2011.10.007

    • Related Report
      2012 Annual Research Report 2011 Research-status Report
  • [Journal Article] Inhibition of morphine tolerance is mediated by painful stimuli via central mechanisms.2012

    • Author(s)
      Iwai S, Kiguchi N, Kobayashi Y, Fukazawa Y, Saika F, Ueno K, Yamamoto C and Kishioka S
    • Journal Title

      Drug Discov Ther.

      Volume: 6(1) Pages: 31-37

    • NAID

      130005054734

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] The role of GITRL-GITR pathway in the development of neuropathic pain.2013

    • Author(s)
      小林悠佳, 木口倫一, 前田武彦, 和木田直希, 岸岡史郎.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Nicotinic acetylcholine receptor signaling located on the bone marrow-derived cells relieves neuropathic pain2013

    • Author(s)
      木口倫一, 小林悠佳, 前田武彦, 岸岡史郎.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Ceramide and its metabolite act as enhancer of pain transmission through spinal glial cells.2013

    • Author(s)
      小林悠佳, 木口倫一, 岸岡史郎
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Angiogenic macrophage contributes to neuropathic pain associated with peripheral neurinflammation.2013

    • Author(s)
      木口倫一, 小林悠佳, 岸岡史郎.
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Macrophage-mediated angiogenesis and neuropathic pain after peripheral nerve injury2013

    • Author(s)
      岸岡史郎, 木口倫一, 小林悠佳, 門脇友維, 和木田直希
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Matrix metalloprotease 12 derived from macrophages participates in pathogenesis of neuropathic pain.2013

    • Author(s)
      Kobayashi Y, Kiguchi N, Yohji Fukazawaet al.
    • Organizer
      International Symposium for Neuroscience
    • Place of Presentation
      仙台
    • Year and Date
      2013-02-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Macrophage inflammatory proteins contributing to neuropathic pain were upregulated by histone modifications after peripheral nerve injury.2013

    • Author(s)
      Kiguchi N, Kobayashi Y and Kishioka S.
    • Organizer
      International Symposium for Neuroscience
    • Place of Presentation
      仙台
    • Year and Date
      2013-02-26
    • Related Report
      2012 Final Research Report
  • [Presentation] The critical role of spinal ceramide in the development of partial sciatic nerve ligation-induced neuropathic pain in mice2012

    • Author(s)
      Kobayashi Y, Kiguchi N and Kishioka S
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      NewOrleans, LA.
    • Year and Date
      2012-10-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Augmentation of MIP-2/CXCR2 axis through histone H3 acetylation in injured peripheral nerves facilitates neuropathic pain.2012

    • Author(s)
      Kiguchi N, Kobayashi Y and Kishioka S
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      NewOrleans, LA.
    • Year and Date
      2012-10-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Nicotine acts on the bone marrow-derived immune cells and prevents neuropathic pain following peripheral nerve injury2012

    • Author(s)
      Kishioka S, Wakida N, Kobayashi Y et al.
    • Organizer
      Neuroscience 2012.
    • Place of Presentation
      NewOrleans, LA.
    • Year and Date
      2012-10-13
    • Related Report
      2012 Final Research Report
  • [Presentation] セラミドによる脊髄グリア細胞活性化は神経障害性疼痛に関与する.2012

    • Author(s)
      小林悠佳, 木口倫一, 和木田直希, 岸岡史郎.
    • Organizer
      第32回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Novel mediators of peripheral sensitization2012

    • Author(s)
      Kishioka S, Kiguchi N, Kobayashi Y et al
    • Place of Presentation
      Calabria, Italy
    • Year and Date
      2012-09-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨髄由来細胞におけるニコチン性アセチルコリン受容体シグナルは神経障害性疼痛を改善する.2012

    • Author(s)
      木口倫一, 小林悠佳, 前田武彦, 冨永信太, 中村淳, 岸岡史郎.
    • Organizer
      第121回日本薬理学会近畿部会
    • Place of Presentation
      徳島
    • Year and Date
      2012-06-29
    • Related Report
      2012 Final Research Report
  • [Presentation] The crosstalk between macrophages and T-lymphocytes plays a crucial role in neuropathic pain.2012

    • Author(s)
      小林悠佳, 木口倫一, 前田武彦, 岸岡史郎
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Macrophage inflammatory proteins produce peripheral neuroinflammation leading to neuropathic pain2012

    • Author(s)
      木口倫一, 小林悠佳, 岸岡史郎
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-14
    • Related Report
      2012 Final Research Report
  • [Presentation] The role of GITRL-GITR pathway in the development of neuropathic pain.2012

    • Author(s)
      小林悠佳、木口倫一、前田武彦、和木田直希、岸岡史郎
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] Nicotinic acetylcholine receptor signaling located on the bone marrow-derived cells relives neuropathic pain.2012

    • Author(s)
      木口倫一、小林悠佳、前田武彦、岸岡史郎
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] The critical role of spinal ceramide in the development of partial sciatic nerve ligation-induced neuropathic pain in mice.2012

    • Author(s)
      Kobayashi Y, Kiguchi N and Kishioka S
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      NEW ORLEANS, LA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Augmentation of MIP-2/CXCR2 axis through histone H3 acetylation in injured peripheral nerves facilitates neuropathic pain.2012

    • Author(s)
      Kiguchi N, Kobayashi Y and Kishioka S
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      NEW ORLEANS, LA
    • Related Report
      2012 Annual Research Report
  • [Presentation] セラミドによる脊髄グリア活性化は神経障害性疼痛に関与する2012

    • Author(s)
      小林悠佳、和木田直希、木口倫一、岸岡史郎
    • Organizer
      第32回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨髄由来細胞におけるニコチン性アセチルコリン受容体シグナルは神経障害性疼痛を改善する2012

    • Author(s)
      木口倫一、小林悠佳、前田武彦、冨永信太、中村 淳、岸岡史郎
    • Organizer
      第121回日本薬理学会近畿部会
    • Place of Presentation
      徳島
    • Related Report
      2012 Annual Research Report
  • [Presentation] The crosstalk between macrophages and T-lymphocytes plays a crucial role in neuropathic pain.2012

    • Author(s)
      Kobayashi Y, Kiguchi N, Maeda T and Kishioka S
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都国際会館、京都
    • Related Report
      2011 Research-status Report
  • [Presentation] Macrophage inflammatory proteins produce peripheral neuroinflammation leading to neuropathic pain.2012

    • Author(s)
      Kiguchi N, Kobayashi Y and Kishioka S
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都国際会館、京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 神経障害性疼痛におけるマクロファージ-T細胞間クロストークを介した GITRL-GITR経路の機能解析2011

    • Author(s)
      小林悠佳, 木口倫一, 岸岡史郎
    • Organizer
      第120回日本薬理学会近畿部会
    • Place of Presentation
      京都
    • Year and Date
      2011-11-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 傷害後坐骨神経における免疫細胞の集積とGITR および GITRL の発現増加2011

    • Author(s)
      小林悠佳, 木口倫一, 岸岡史郎.
    • Organizer
      5回日本緩和医療薬学会年会
    • Place of Presentation
      幕張
    • Year and Date
      2011-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] GITRL-GITR pathway involves in neuropathic pain through the crosstalk between macrophages and T -lymphocytes.2011

    • Author(s)
      Kobayashi Y, Kiguchi N and Kishioka S.
    • Organizer
      Italian-Japanese International Seminar for Neurosciences
    • Place of Presentation
      仙台
    • Year and Date
      2011-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Augmentation of MIP-2/CXCR2 axis due to histone H3 acetylation in injured peripheral nerves contributes to neuropathic pain.2011

    • Author(s)
      Kiguchi N, Kobayashi Y and Kishioka S.
    • Organizer
      Italian-Japanese International Seminar for Neurosciences.
    • Place of Presentation
      仙台
    • Year and Date
      2011-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 末梢ニコチン性アセチルコリン受容体を介する神経障害性疼痛抑制機構2011

    • Author(s)
      木口倫一, 小林悠佳, 前田武彦, 中村淳,冨永信太, 岸岡史郎.
    • Organizer
      第119回日本薬理学会近畿部会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-07-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Nicotine prevents neuropathic pain following peripheral nerve injury through the suppression of neuroinflammation.2011

    • Author(s)
      Kishioka S, Kiguchi N, Kobayashi Y et al.
    • Organizer
      The 42 th International Narcotics Research Conference
    • Place of Presentation
      Hollywood, FL
    • Year and Date
      2011-06-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Peroxisome proliferator-activated receptor gamma activation relieves expression of behavioral sensitization to methamphetamine and of neuropathic pain in mice.2011

    • Author(s)
      Kishioka S, Maeda T, Kobayashi Y et al
    • Organizer
      2011 meeting of Behavior, Biology and Chemistry: TranslationalResearch in Addiction.
    • Place of Presentation
      San Antonio, TX.
    • Year and Date
      2011-03-05
    • Related Report
      2012 Final Research Report
  • [Presentation] GITRL-GITR pathway involves in neuropathic pain through the crosstalk between macrophages and T-lymphocytes.2011

    • Author(s)
      Kobayashi Y, Kiguchi N and Kishioka S
    • Organizer
      Italian-Japanese International Seminar for Neurosciences.
    • Place of Presentation
      東北薬科大学、仙台
    • Related Report
      2011 Research-status Report
  • [Presentation] Augmentation of MIP-2/CXCR2 axis due to histone H3 acetylation in injured peripheral nerves contributes to neuropathic pain.2011

    • Author(s)
      Kiguchi N, Kobayashi Y and Kishioka S
    • Organizer
      Italian-Japanese International Seminar for Neurosciences.
    • Place of Presentation
      東北薬科大学、仙台
    • Related Report
      2011 Research-status Report
  • [Presentation] Nicotinic effects and its receptor subtype-nicotine-induced inhibition of nociceptive pain and neuropathic pain-.2011

    • Author(s)
      Kishioka S, Kobayashi Y and Kiguchi N
    • Organizer
      Italian-Japanese International Seminar for Neurosciences.(招待講演)
    • Place of Presentation
      東北薬科大学、仙台
    • Related Report
      2011 Research-status Report
  • [Presentation] 末梢ニコチン性アセチルコリン受容体を介する神経障害性疼痛抑制機構2011

    • Author(s)
      木口倫一、小林悠佳、中村淳、冨永信太、岸岡史郎
    • Organizer
      第119回日本薬理学会近畿部会
    • Place of Presentation
      ウィンクあいち、名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] MIP-1βは神経障害性疼痛を惹起する2011

    • Author(s)
      雑賀史浩、木口倫一、小林悠佳、岸岡史郎
    • Organizer
      第79回和歌山医学会総会
    • Place of Presentation
      和歌山県立医科大学、和歌山
    • Related Report
      2011 Research-status Report
  • [Presentation] ヒストンアセチル化に基づくCXCL2発現増加は神経障害性疼痛に関与する2011

    • Author(s)
      木口倫一、小林悠佳、岸岡史郎
    • Organizer
      第79回和歌山医学会総会
    • Place of Presentation
      和歌山県立医科大学、和歌山
    • Related Report
      2011 Research-status Report
  • [Presentation] 傷害後坐骨神経における免疫細胞の集積とGITRおよびGITRLの発現増加2011

    • Author(s)
      小林悠佳、木口倫一、岸岡史郎
    • Organizer
      第5回緩和医療薬学会
    • Place of Presentation
      ホテルグランヴィア京都、京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 神経障害性疼痛におけるマクロファージ-T細胞間クロストークを介したGITRL-GITR経路の機能解析2011

    • Author(s)
      小林悠佳、木口倫一、岸岡史郎
    • Organizer
      第120回日本薬理学会近畿部会
    • Place of Presentation
      幕張メッセ、千葉
    • Related Report
      2011 Research-status Report
  • [Presentation] MIP-2が担う神経障害性疼痛形成機構における好中球の役割2011

    • Author(s)
      木口倫一、小林悠佳、岸岡史郎
    • Organizer
      第120回日本薬理学会近畿部会
    • Place of Presentation
      ホテルグランヴィア京都、京都
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.wakayama-med.ac.jp/dept/igakubu/160416/

    • Related Report
      2012 Final Research Report
  • [Remarks] 和歌山県立医科大学 薬理学教室

    • URL

      http://www.wakayama-med.ac.jp/dept/igakubu/160416/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.wakayama-med.ac.jp/dept/igakubu/160416/index.html

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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