The mechanism of HMGB1 in the pathogenesis of septic encephalopathy

Research Project

Project/Area Number	23791728
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Teikyo University
Principal Investigator	SAKAMOTO HIDETOSHI 帝京大学, 医学部, 講師 (90349267)
Project Period (FY)	2011 – 2013
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	脳・神経 / 敗血症 / HMGB1 / 睡眠・覚醒 / MCH / 記憶 / 集中治療 / ＨＭＧＢ１
Research Abstract	We demonstrated that intracerebroventricular (icv) injection of HMGB1(High mobility group box 1) reduced awakening period, and increased the non-rapid eye movement episode time.We also demonstrated that icv injection of melanin-concentrating hormone(MCH) increased hippocampal acetylcholine release in both HMGB1 (pre-treatment) group and normal saline(pre-treatment) group. Icv injection of HMGB1 did not reduce the hippocampus acetylcholine release, and had no effect on hippocampal acetylcholine release after icv injection of MCH.