Effect of opioids on tumor growth and stem cell differentiation
| Project/Area Number |
23791731
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Keio University |
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Principal Investigator |
KUZUMAKI Naoko 慶應義塾大学, 医学部, 特任助教 (10507669)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 麻酔学 / オピオイド / がん細胞 / GPCR / 抗がん剤耐性 / 非小細胞肺がん / 非小細胞性肺がん / ゲフィチニブ耐性 |
|---|
| Research Abstract |
To determine the expression profile of GPCRs in gefitinib-sensitive (HCC827) and gefitinib-resistant NSCLC cells (H1975, HCC827GR), a GPCR-specific microarray analysis was performed. A heat-map of the microarray revealed considerable differences in the ex
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Effect of k-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells2012
Author(s)
Kuzumaki N, Suzuki A, Narita M, Hosoya T, Nagasawa A, Imai S, Yamamizu K, Morita H, Nagase H, Okada Y, Okano HJ, Yamashita JK, Okano H, Suzuki T, Narita M
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Journal Title
Br J Cancer
Volume: 106(Epub 2012 Feb 16)
Issue: 6
Pages: 1148-1152
DOI
Related Report
Peer Reviewed
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[Journal Article] Multiple analyses of G-protein coupled receptor (GPCR) expression in the development of gefitinib-resistance in transforming non-small-cell lung cancer.2012
Author(s)
Kuzumaki N, Suzuki A, Narita M, Hosoya T, Nagasawa A, Imai S, Yamamizu K, Morita H, Suzuki T, Okada Y, Okano HJ, Yamashita JK, Okano H, Narita M.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells.2012
Author(s)
Kuzumaki N, Suzuki A, Narita M, Hosoya T, Nagasawa A, Imai S, Yamamizu K, Morita H, Nagase H, Okada Y, Okano HJ, Yamashita JK, Okano H, Suzuki T, Narita M.
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Journal Title
Br J Cancer.
Volume: 106
Pages: 1148-52
Related Report
Peer Reviewed
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[Presentation] Suppression of cell growth and cancer stem cell properties of gefitinib-resistant non-small-cell lung cancer (NSCLC) cells by activation of delta-opioidergic system2011
Author(s)
Kuzumaki N, Suzuki A, Narita M, Yamamizu K, Nagasawa A, Okada Y, Okano HJ, Okano H, Yamashita JK, Suzuki T, Narita M
Organizer
The International nalcotic research conference 2011
Place of Presentation
Westin Diplomat Hotel, Florida, U.S.A
Related Report
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