Effect of opioids on tumor growth and stem cell differentiation

• Project/Area Number: 23791731
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Keio University
• Principal Investigator: KUZUMAKI Naoko 慶應義塾大学, 医学部, 特任助教 (10507669)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 麻酔学 / オピオイド / がん細胞 / GPCR / 抗がん剤耐性 / 非小細胞肺がん / 非小細胞性肺がん / ゲフィチニブ耐性

Research Abstract

To determine the expression profile of GPCRs in gefitinib-sensitive (HCC827) and gefitinib-resistant NSCLC cells (H1975, HCC827GR), a GPCR-specific microarray analysis was performed. A heat-map of the microarray revealed considerable differences in the ex

Research Products

• [Journal Article] Multiple analyses of G-protein coupled receptor (GPCR) expression in the development of gefitinib-resistance in transforming non-small-cell lung cancer. (2012)
  • Author(s): Kuzumaki N
  • Journal Title: PLoS One Volume: 7 Issue: 10 Pages: e44368-e44368
  • DOI: 10.1371/journal.pone.0044368
  • Peer Reviewed
• [Journal Article] Effect of k-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells (2012)
  • Author(s): Kuzumaki N, Suzuki A, Narita M, Hosoya T, Nagasawa A, Imai S, Yamamizu K, Morita H, Nagase H, Okada Y, Okano HJ, Yamashita JK, Okano H, Suzuki T, Narita M
  • Journal Title: Br J Cancer Volume: 106(Epub 2012 Feb 16) Issue: 6 Pages: 1148-1152
  • DOI: 10.1038/bjc.2011.574
  • Peer Reviewed
• [Journal Article] Multiple analyses of G-protein coupled receptor (GPCR) expression in the development of gefitinib-resistance in transforming non-small-cell lung cancer. (2012)
  • Author(s): Kuzumaki N, Suzuki A, Narita M, Hosoya T, Nagasawa A, Imai S, Yamamizu K, Morita H, Suzuki T, Okada Y, Okano HJ, Yamashita JK, Okano H, Narita M.
  • Journal Title: PLoS One. Volume: 7
  • Peer Reviewed
• [Journal Article] Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells. (2012)
  • Author(s): Kuzumaki N, Suzuki A, Narita M, Hosoya T, Nagasawa A, Imai S, Yamamizu K, Morita H, Nagase H, Okada Y, Okano HJ, Yamashita JK, Okano H, Suzuki T, Narita M.
  • Journal Title: Br J Cancer. Volume: 106 Pages: 1148-52
  • Peer Reviewed
• [Journal Article] The kappa opioid system regulates endothelial cell differentiation and pathfinding in vascular development (2011)
  • Author(s): Yamamizu K, Furuta S, Katayama S, Narita M, Kuzumaki N, Imai S, Nagase H, Suzuki T, Narita M, Yamashita JK
  • Journal Title: Blood(表紙) Volume: 118 Issue: 3 Pages: 775-785
  • DOI: 10.1182/blood-2010-09-306001
  • Peer Reviewed
• [Presentation] G-蛋白共役型受容体によるゲフィチニブ耐性ヒト非小細胞肺がん増殖制御の可能性 (2012)
  • Author(s): 葛巻直子、長澤阿津実、成田道子、濱田祐輔、岡野栄之、成田 年
  • Organizer: 第50回日本癌治療学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Gefitinib 耐性ヒと非小細胞肺がん細胞の増殖抑制機構におけるG-protein coupled receptor (GPCR) の役割 (2012)
  • Author(s): 葛巻直子、成田年
  • Organizer: 第6回緩和医療薬学会
  • Place of Presentation: 神戸
• [Presentation] オピオイドによるゲフィチニブ耐性ヒト非小細胞肺がん細胞の増殖制御 (2012)
  • Author(s): 葛巻直子、長澤阿津実、成田道子、濱田祐輔、岡野栄之、成田年
  • Organizer: 第32回鎮痛薬・オピオイドペプチドシンポジウム
  • Place of Presentation: JR 東京総合病院
• [Presentation] G-蛋白共役型受容体によるゲフィチニブ耐性ヒト非小細胞肺がん増殖制御の可能性 (2012)
  • Author(s): 葛巻直子
  • Organizer: 第50 回癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Gefitinib 耐性ヒト非小細胞肺がん細胞の増殖制御機構におけるG-protein coupled receptor (GPCR) の役割 (2012)
  • Author(s): 葛巻直子
  • Organizer: 第 6 回緩和医療薬学会年会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Suppression of cell growth and cancer stem cell properties of gefitinib-resistant non-small-cell lung cancer (NSCLC) cells by activation of delta-opioidergic system (2011)
  • Author(s): Kuzumaki N, Suzuki A, Narita M, Yamamizu K, Nagasawa A, Okada Y, Okano HJ, Okano H, Yamashita JK, Suzuki T, Narita M
  • Organizer: The International nalcotic research conference 2011
  • Place of Presentation: Westin Diplomat Hotel, Florida, U.S.A
• [Presentation] G-protein coupled receptor (GPCR) を介したヒト非小細胞肺がん細胞の増悪化の制御機構 (2011)
  • Author(s): 葛巻直子、 岡野栄之、 成田 年
  • Organizer: 第 5 回緩和医療薬学会年会
  • Place of Presentation: 幕張メッセ、千葉
• [Presentation] ES 細胞からの神経幹細胞誘導における G-protein coupled receptor 発現の網羅的解析 (2011)
  • Author(s): 葛巻直子、成田道子、濱田祐輔、長澤阿津実、岡田洋平、赤松和土、岡野ジェイムス洋尚、岡野栄之、成田 年
  • Organizer: 第 34 回日本神経科学大会
  • Place of Presentation: パシフィコ横浜・神奈川
• [Book] オピオイドが示す多彩な生理応答: 血管新生やがん細胞増殖に及ぼす役割、ペインクリニック別冊秋号 (2012)
  • Author(s): 葛巻直子、山水康平、濱田祐輔、長澤阿津実、山下 潤、成田 年
  • Publisher: 新興交易
• [Book] トワイクロス先生のがん緩和ケア処方薬-薬効・薬理と薬の使い方、4 中枢神経薬、抗うつ薬 (2012)
  • Author(s): 葛巻直子 (分担翻訳)、監訳: 武田文和、鈴木勉
  • Publisher: 医学書院
• [Book] オピオイドが示す多彩な生理応答: 血管新生やがん細胞増殖に及ぼす役割 (2012)
  • Author(s): 葛巻直子
  • Total Pages: 8
  • Publisher: 新興交易(株) 医学出版部