Development of novel ABO blood group antigen targeting peptide that suppress rejection during ABO-incompatible kidney transplantation
Project/Area Number |
23791736
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | Hirosaki University |
Principal Investigator |
YONEYAMA Tohru 弘前大学, 医学(系)研究科(研究院), 助教 (50587649)
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Project Period (FY) |
2011-04-28 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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Keywords | 血液型不適合腎移植 / ABO抗原標的ペプチド / ABO抗原標的ぺプチド / 国際情報交換 / 国際情報交流 |
Outline of Final Research Achievements |
Antibody-mediated rejection after ABO-incompatible kidney transplantation (ABO-I KTx) is a major barrier to transplantation success. Clinical conditions during ABO-I KTx are difficult to control because of overimmunosuppression. To reduce the need for immunosuppression, we screened for an ABO blood group antigen-targeting peptide (BATP) by screening of T7 phage-displayed peptide library and identified six peptide sequences that efficiently suppressed binding of anti-ABO blood group antibodies (Abs) to ABO histo-blood group antigens in kidney tissues. Surprisingly, ex vivo perfusion of BATP in kidneys caused significant suppression of anti-blood group Ab binding to antigen and IgG and IgM deposition in renal glomerular capillaries after ABO-I blood reperfusion. These data indicate that A/B blood group antigens in kidney tissues may be neutralized by BATP. This approach may enable the development of a novel blood group antigen-neutralizing therapy to overcome the challenges of ABO-I KTx.
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Report
(5 results)
Research Products
(17 results)
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[Journal Article] Blood group antigen-targeting peptide suppresses anti-blood group antibody binding to antigen in renal glomerular capillaries after ABO-incompatible blood reperfusion.2013
Author(s)
Yoneyama T, Hatakeyama S, Tobisawa Y, Yamamoto H, Imanishi K, Okamoto T, Tokui N, Sugiyama N, Suzuki Y, Kudo S, Yoneyama T, Hashimoto Y, Koie T, Kamimura N, Fukuda NM, Ohyama C
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Journal Title
Transplantation
Volume: 95(3)
Issue: 3
Pages: 418-425
DOI
Related Report
Peer Reviewed
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[Presentation] BLOOD GROUP ANTIGEN-TARGETING PEPTIDE SUPPRESSES BLOOD CLOTTING AND IMMUNOGLOBULIN DEPOSITION IN RENAL GLOMERULAR CAPILLARIES AFTER ABO-INCOMPATIBLE BLOOD REPERFUSION2014
Author(s)
Tohru Yoneyama, Shingo Hatakeyama, Yuki Tobisawa, Hayato Yamamoto, Teppei Okamoto, Noriko Tokui, Kengo Imanishi, Atsushi Imai, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Michiko N Fukuda and Chikara Ohyama
Organizer
Hirosaki International Symposium on transplant
Place of Presentation
弘前市
Year and Date
2014-10-31
Related Report
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[Presentation] Blood group antigen-targeting peptide suppresses blood clotting and immunoglobulin deposition in renal glomerular capillaries after ABO-incompatible blood reperfusion2013
Author(s)
Tohru Yoneyama, Shingo Hatakeyama, Yuki Tobisawa, Hayato Yamamoto, Yuichiro Suzuki, Akiko Okamoto, Atsushi Imai, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Michiko N Fukuda and Chikara Ohyama
Organizer
第12回国際異種移植学会議 (IXA 2013)
Place of Presentation
大阪
Related Report
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[Presentation] Blood group antigen-targeting peptide suppresses anti-blood group antibody binding to antigen in renal glomerular capillaries after ABO-incompatible blood reperfusion2013
Author(s)
Yoneyama T, Hatakeyama S, Tobisawa Y, Yamamoto H, Imanishi K, Okamoto T, Tokui N, Sugiyama N, Suzuki Y, Kudo S, Yoneyama T, Hashimoto Y, Koie T, Kamimura N, Fukuda NM, Ohyama C
Organizer
28th Annual EAU Congress(第28回欧州泌尿器科学会総会)
Place of Presentation
イタリア、ミラノ市
Related Report
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[Presentation] Blood group antigen-targeting peptide suppresses anti-blood group antibody binding to antigen in renal glomerular capillaries after ABO-incompatible blood reperfusion2013
Author(s)
Yoneyama T, Hatakeyama S, Tobisawa Y, Yamamoto H, Imanishi K, Okamoto T, Tokui N, Sugiyama N, Suzuki Y, Kudo S, Yoneyama T, Hashimoto Y, Koie T, Kamimura N, Fukuda NM, Ohyama C
Organizer
Annual meeting of American Urological Association 2013(米国泌尿器科学会総会)
Place of Presentation
アメリカ、サンディエゴ市
Related Report
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[Presentation] Blocking of blood group A- or B-antigen by blood group specific binding peptide: new strategy by overcoming ABO incompatible kidney transplantation2011
Author(s)
Yoneyama T., Hatakeyama S., Imanishi K., Tokui N., Okamoto T., Sugiyama N., Suzuki Y., Kudo S., Yoneyama T., Koie T., Kamimura N., Ohyama C.
Organizer
Annual meeting of American Urological Association 2011 (アメリカ泌尿器科学会)
Place of Presentation
アメリカ(ワシントン)
Related Report
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[Presentation] Blood group antigen targeting peptide suppresses thrombotic microangiopathy in renal glomerular capillary after ABO-incompatible blood re-perfusion2011
Author(s)
Yoneyama T., Hatakeyama S., Imanishi K., Tokui N., Okamoto T., Sugiyama N., Suzuki Y., Kudo S., Yoneyama T., Koie T., Kamimura N., Ohyama C.
Organizer
第31回内藤コンファレンス
Place of Presentation
札幌市
Related Report
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