Targeted drug delivery to tumor vasculature by annexin A1 binding peptide

• Project/Area Number: 23791737
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Hirosaki University
• Principal Investigator: HATAKEYAMA Shingo 弘前大学, 医学部附属病院, 講師 (10400136)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 癌特異的化学療法 / ペプチド / 癌特異的抗癌剤 / 前立腺癌 / 癌化学療法 / アネキシン

Outline of Final Research Achievements

One of the big limitations of toxic chemotherapy is severe adverse events. Therefore, targeting therapy for solid cancer is required. Because annexin A1 (AnxA1) is identified as a highly specific tumor vasculature surface marker, we identified AnxA1 binding peptide that could target anticancer drugs to tumor vasculature. We conjugated AnxA1 binding peptide with anticancer agents, and treated cancer bearing mice. We observed antitumor effects; however dosage adjustment seems to be needed to obtain efficient anticancer effect.

Research Products

• [Journal Article] Preoperative butyrylcholinesterase level as an independent predictor of overall survival in clear cell renal cell carcinoma patients treated with nephrectomy. (2014)
  • Author(s): Koie T, Ohyama C, Mikami J, Iwamura H, Fujita N, Sato T, Kojima Y, Fukushi K, Yamamoto H, Imai A, Hatakeyama S, Yoneyama T, Hashimoto Y, Kitayama M, Hirota K.
  • Journal Title: ScientificWorldJournal. Volume: 2014 Pages: 948305-948305
  • DOI: 10.1155/2014/948305
  • Peer Reviewed / Open Access
• [Journal Article] Differences in the recurrence pattern after neoadjuvant chemotherapy compared to surgery alone in patients with muscle-invasive bladder cancer. (2014)
  • Author(s): Koie T, Ohyama C, Yamamoto H, Imai A, Hatakeyama S, Yoneyama T, Hashimoto Y, Yoneyama T, Tobisawa Y.
  • Journal Title: Med Oncol. Volume: 32 Issue: 1 Pages: 421-421
  • DOI: 10.1007/s12032-014-0421-x
  • Peer Reviewed
• [Journal Article] Serum tri-and tetra-antennary N-glycan is a potential predictive biomarker for castration-resistant prostate cancer. (2014)
  • Author(s): Ishibashi Y, Tobisawa Y, Hatakeyama S, Ohashi T, Tanaka M, Narita S, Koie T, Habuchi T, Nishimura S, Ohyama C, Yoneyama T
  • Journal Title: Prostate Volume: 74 Issue: 15 Pages: 1521-1529
  • DOI: 10.1002/pros.22869
  • Peer Reviewed / Open Access
• [Journal Article] Tubulocystic renal cell carcinoma in the left kidney: a case report. (2014)
  • Author(s): Ishibashi Y, Koie T, Fujita N, Satoh T, Mikami J, Hatakeyama S, Ohyama C, Tobisawa Y, Yoneyama T.
  • Journal Title: J Med Case Rep. Volume: 8 Issue: 1 Pages: 265-265
  • DOI: 10.1186/1752-1947-8-265
  • Peer Reviewed
• [Journal Article] Significance of preoperative butyrylcholinesterase as an independent predictor of survival in patients with muscle-invasive bladder cancer treated with radical cystectomy. (2014)
  • Author(s): Koie T, Ohyama C, Yamamoto H, Hatakeyama S, Imai A, Yoneyama T, Hashimoto Y, Kitayam M, Hirota K.
  • Journal Title: Urol Oncol. Volume: 32 Issue: 6 Pages: 820-825
  • DOI: 10.1016/j.urolonc.2014.03.010
  • Peer Reviewed
• [Journal Article] arboplatin-based combination chemotherapy for elderly patients with advanced bladder cancer. (2014)
  • Author(s): Yoneyama T, Tobisawa Y, Yoneyama T, Yamamoto H, Imai A, Hatakeyama S, Hashimoto Y, Koie T, Ohyama C.
  • Journal Title: Int J Clin Oncol. Volume: 20 Issue: 2 Pages: 369-374
  • DOI: 10.1007/s10147-014-0706-2
  • Peer Reviewed
• [Journal Article] Measurement of aberrant glycosylation of prostate specific antigen can improve specificity in early detection of prostate cancer. (2014)
  • Author(s): Yoneyama T, Ohyama C, Hatakeyama S, Narita S, Habuchi T, Koie T, Mori K, Hidari KI, Yamaguchi M, Suzuki T, Tobisawa Y
  • Journal Title: Biochem Biophys Res Commun. Volume: 448 Issue: 4 Pages: 390-396
  • DOI: 10.1016/j.bbrc.2014.04.107
  • Peer Reviewed / Open Access
• [Journal Article] Vimentin intermediate filament and plectin provide a scaffold for invadopodia, facilitating cancer cell invasion and extravasation for metastasis (2014)
  • Author(s): Sutoh Yoneyama, M., Hatakeyama, S.,Habuchi, T., Inoue, T., Nakamura, T.,Funyu, T., Wiche, G., Ohyama, C. and Tsuboi, S.
  • Journal Title: European Journal of Cell Biology Volume: (in press) Issue: 4 Pages: 157-169
  • DOI: 10.1016/j.ejcb.2014.03.002
  • Peer Reviewed
• [Journal Article] Reassessment of prognostic heterogeneity of pT3 renal pelvic urothelial carcinoma: analysis in terms of proposed pT3 subclassification systems. (2014)
  • Author(s): Park J, Habuchi T, Arai Y, Ohyama C, Inoue T, Hatakeyama S, Jeon SS, Kwon GY, Kwak C, Moon KC, Kim CS, Ahn H.
  • Journal Title: J Urol. Volume: 192 Issue: 4 Pages: 1064-1071
  • DOI: 10.1016/j.juro.2014.04.001
  • Peer Reviewed
• [Journal Article] Neoadjuvant gemcitabine and carboplatin followed by immediate cystectomy may be associated with a survival benefit in patients with clinical T2 bladder cancer. (2014)
  • Author(s): Koie T, Ohyama C, Yamamoto H, Imai A, Hatakeyama S, Yoneyama T, Hashimoto Y, Yoneyama T, Tobisawa Y.
  • Journal Title: Med Oncol. Volume: 31 Issue: 5 Pages: 949-949
  • DOI: 10.1007/s12032-014-0949-9
  • Peer Reviewed
• [Journal Article] Invadopodia play an essential role in transendothelial invasion during muscle invasion of bladder cancer cells (2014)
  • Author(s): Imanishi, K., Sutoh Yoneyama, M.,Hatakeyama, S., Yamamoto, H., Koie, T.,Saitoh, H., Yamaya, K., Funyu, T.,Nakamura, T., Ohyama, C. and Tsuboi,S.
  • Journal Title: Molecular Medicine Reports Volume: (in press) Issue: 6 Pages: 2159-2165
  • DOI: 10.3892/mmr.2014.2113
  • Peer Reviewed
• [Journal Article] Extravasation during bladder cancer metastasis requires cortactin-mediated invadopodia formation (2014)
  • Author(s): Tokui, N., Sutoh Yoneyama, M.,Hatakeyama, S., Yamamoto, H., Koie, T.,Saitoh, H., Yamaya, K., Funyu, T.,Nakamura, T., Ohyama, C. and Tsuboi,S.
  • Journal Title: Molecular Medicine Reports Volume: 9 Issue: 4 Pages: 1142-1146
  • DOI: 10.3892/mmr.2014.1965
  • Peer Reviewed
• [Journal Article] Fat-poor renal angiomyolipoma in a patient with a end-stage kidney (2014)
  • Author(s): Murasawa H, Koie T, Hatakeyama S, Hashimoto Y, Yoneyama T, Saitoh H, Ohyama C, Funyu T
  • Journal Title: Int Canc Conf J Volume: 3 Issue: 1 Pages: 48-51
  • DOI: 10.1007/s13691-013-0114-x
  • Peer Reviewed
• [Journal Article] Serum N-glycan alteration associated with renal cell carcinoma detected by high-throughput glycan analysis. (2014)
  • Author(s): Hatakeyama S, Amano M, Tobisawa Y, Yoneyama T, Tsuchiya N, Habuchi T, Nishimura SI, Ohyama C
  • Journal Title: J Urol. Volume: 191 Issue: 3 Pages: 805-813
  • DOI: 10.1016/j.juro.2013.10.052
  • Peer Reviewed / Open Access
• [Journal Article] A case of metastatic cancer with markedly elevated PSA level that was not detected by repeat prostate biopsy (2014)
  • Author(s): Iwamura H, Hatakeyama S, Tanaka Y, Tanaka T, Tokui N, Yamamoto H, Imai A, Yoneyama T, Hashimoto Y, Koie T, Yoshikawa K, Ohyama C
  • Journal Title: BMC Res Notes Volume: 7 Issue: 1 Pages: 64-67
  • DOI: 10.1186/1756-0500-7-64
  • Peer Reviewed
• [Journal Article] Expression of a Y-located human proto-oncogene TSPY in a transgenic mouse model of prostate cancer (2014)
  • Author(s): Kido T, Schubert S, Hatakeyama S, Ohyama C, Schmidtke J, Lau YF
  • Journal Title: Cell Biosci Volume: 17 Issue: 1 Pages: 9-12
  • DOI: 10.1186/2045-3701-4-9
  • Peer Reviewed
• [Journal Article] Renal cell carcinoma detected by preoperative kidney transplant donor examination: a case report. (2014)
  • Author(s): Sato T, Yoneyama T, Hagiwara K, Narita T, Noro D, Tanaka T, Tanaka Y, Tobisawa Y, Yoneyama T, Yamamoto H, Okamoto A, Imai A, Hatakeyama S, Hashimoto Y, Koie T, Ohyama C.
  • Journal Title: Transplant Proc. Volume: 46 Issue: 2 Pages: 634-636
  • DOI: 10.1016/j.transproceed.2013.11.022
  • Peer Reviewed
• [Journal Article] BK Virus-Associated Urothelial Carcinoma of a Ureter Graft in a Renal Transplant Recipient: A Case Report. (2014)
  • Author(s): Oikawa M, Hatakeyama S, Fujita T, Murakami R, Hagiwara K, Narita T, Noro D, Tanaka T, Tanaka Y, Tobisawa Y, Yoneyama T, Yoneyama T, Hashimoto Y, Koie T, Narumi S, Ohyama C.
  • Journal Title: Transplant Proc. Volume: 46 Issue: 2 Pages: 616-619
  • DOI: 10.1016/j.transproceed.2013.09.037
  • Peer Reviewed
• [Journal Article] Post-transplant Renal Function and Cardiovascular Events Are Closely Associated With the Aortic Calcification Index in Renal Transplant Recipients. (2014)
  • Author(s): Imanishi K, Hatakeyama S, Yamamoto H, Okamoto A, Imai A, Yoneyama T, Hashimoto Y, Koie T, Fujita T, Murakami R, Saitoh H, Funyu T, Narumi S, Ohyama C.
  • Journal Title: Transplant Proc. Volume: 46 Issue: 2 Pages: 484-488
  • DOI: 10.1016/j.transproceed.2013.09.039
  • Peer Reviewed
• [Journal Article] Outcome Comparison of ABO-Incompatible Kidney Transplantation With Low-Dose Rituximab and ABO-Compatible Kidney Transplantation: A Single-Center Experience. (2014)
  • Author(s): Hatakeyama S, Fujita T, Murakami R, Suzuki Y, Sugiyama N, Yamamoto H, Okamoto A, Imai A, Tobisawa Y, Yoneyama T, Mori K, Yoneyama T, Hashimoto Y, Koie T, Narumi S, Ohyama C.
  • Journal Title: Transplant Proc. Volume: 46 Issue: 2 Pages: 445-448
  • DOI: 10.1016/j.transproceed.2013.09.036
  • Peer Reviewed
• [Journal Article] Gene Expression Changes in Venous Segment of Overflow Arteriovenous Fistula (2013)
  • Author(s): Hashimoto Y, Okamoto A, Saitoh H, Hatakeyama S, Yoneyama T, Koie T, Ohyama C：Gene Expression Changes in Venous Segment of Overflow Arteriovenous Fistula．
  • Journal Title: Int J of Nephrology Volume: Volume 2013 Pages: 1-8
  • DOI: 10.1155/2013/980923
  • Peer Reviewed
• [Journal Article] Attenuation of fibroblast growth factor signaling by poly -N- acatyllactosamine type glycans. (2013)
  • Author(s): Sugihara K, Shibata TK, Takata K, Kimura T, Kanayama N, Williams R, Hatakeyama S, Akama TO, Kuo CW, Khoo KH, Fukuda MN
  • Journal Title: FEBS letters Volume: 587 Issue: 19 Pages: 3195-3201
  • DOI: 10.1016/j.febslet.2013.07.056
  • Peer Reviewed
• [Journal Article] In vivo selection of high-metastatic subline of bladder cancer cell and its characterization (2013)
  • Author(s): Sugiyama N, Yoneyama MS, Hatakeyama S, Yamamoto H, Okamoto A, Koie T, Saitoh H, Yamaya K, Funyu T, Inoue T, Habuchi T, Ohyama C, Tsuboi S
  • Journal Title: Oncol Res. Volume: 20 Pages: 289-295
  • Peer Reviewed
• [Journal Article] Prognosis of Elderly Japanese Patients Aged ≥80 Years Undergoing Hemodialysis (2013)
  • Author(s): Hatakeyama S, Murasawa H, Hamano I, Kusaka A, Narita T, Oikawa M, Noro D, Hagiwara K, Ishimura H, Yoneyama T, Hashimoto Y, Koie T, Saitoh H, Funyu T, Ohyama C
  • Journal Title: The Scientific World Journal Volume: Volume 2013 Issue: 1
  • DOI: 10.1155/2013/693514
  • Peer Reviewed
• [Journal Article] Switching hemodialysis patients from sevelamer hydrochloride to bixalomer: a single-center, non-randomized analysis of efficacy and effects on gastrointestinal symptoms and metabolic acidosis (2013)
  • Author(s): Hatakeyama S, Murasawa H, Narita T, Oikawa M, Fujita N, Iwamura H, Mikami J, Kojima Y, Sato T, Fukushi K, Ishibashi Y, Hashimoto Y, Koie T, Saitoh H, Funyu T, Ohyama C
  • Journal Title: BMC Nephrol. Volume: 14 Issue: 1 Pages: 222-224
  • DOI: 10.1186/1471-2369-14-222
  • Peer Reviewed
• [Journal Article] Neoadjuvant chemotherapy with gemcitabine plus carboplatin followed by immediate radical cystectomy for muscle-invasive bladder cancer (2013)
  • Author(s): Ohyama C, Hatakeyama S, Yoneyama T, Koie T
  • Journal Title: Int J Urol. Volume: 21 Issue: 1 Pages: 3-4
  • DOI: 10.1111/iju.12230
  • Peer Reviewed
• [Journal Article] Distinct cancer-specific survival in metastatic prostate cancer patients classified by a panel of single nucleotide polymorphisms of cancer-associated genes. (2013)
  • Author(s): Tsuchiya N, Matsui S, Narita S, Kamba T, Mitsuzuka K, Hatakeyama S, Horikawa Y, Inoue T, Saito S, Ohyama C, Arai Y, Ogawa O, Habuchi T.
  • Journal Title: Genes Cancer. Volume: 4 Issue: 1-2 Pages: 54-60
  • DOI: 10.1177/1947601913481354
  • Peer Reviewed
• [Journal Article] Chromophobe renal cell carcinoma with concomitant sarcomatoid transformation and osseous metaplasia: a case report. (2013)
  • Author(s): Tanaka Y, Koie T, Hatakeyama S, Hashimoto Y, Ohyama C.
  • Journal Title: BMC Urol. Volume: 13 Issue: 1 Pages: 72-74
  • DOI: 10.1186/1471-2490-13-72
  • Peer Reviewed
• [Journal Article] Serum N-glycan profiling predicts prognosis in patients undergoing hemodialysis. (2013)
  • Author(s): Hatakeyama S, Amano M, Tobisawa Y, Yoneyama T, Tsushima M, Hirose K, Yoneyama T, Hashimoto Y, Koie T, Saitoh H, Yamaya K, Funyu T, Nishimura S, Ohyama C.
  • Journal Title: The Scientific World Journal Volume: 20 Issue: 1
  • DOI: 10.1155/2013/268407
  • Peer Reviewed
• [Journal Article] Insulin-like growth factor-1 genotypes and haplotypes influence the survival of prostate cancer patients with bone metastasis at initial diagnosis (2013)
  • Author(s): Tsuchiya N
  • Journal Title: BMC Cancer Volume: 13 Issue: 1 Pages: 150-150
  • DOI: 10.1186/1471-2407-13-150
  • Peer Reviewed
• [Journal Article] Two opposing roles of O-glycans in tumor metastasis (2012)
  • Author(s): Tsuboi, S., Hatakeyama, S., Ohyama,C. and Fukuda, M.
  • Journal Title: Trends in Molecular Medicine Volume: 18 Issue: 4 Pages: 224-232
  • DOI: 10.1016/j.molmed.2012.02.001
  • Peer Reviewed
• [Journal Article] MUC1 carrying core 2 O-glycans functions as a molecular shield against NK cell attack, promoting bladder tumor metastasis (2012)
  • Author(s): Suzuki Y, et al.
  • Journal Title: International Journal of Onocology Volume: (未定)(in press) Pages: 1831-1838
  • DOI: 10.3892/ijo.2012.1411
  • Peer Reviewed
• [Journal Article] Sarcoidosis of the ureter. (2012)
  • Author(s): Hashimoto Y, Kudoh S, Yamamoto H, Hatakeyama S, Yoneyama T, Koie T, Kamimura N, Ohyama C.
  • Journal Title: Urology. Volume: 79 Issue: 6 Pages: 81-82
  • DOI: 10.1016/j.urology.2012.02.045
  • Peer Reviewed
• [Journal Article] Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease (2012)
  • Author(s): Hatakeyama S, Yamamoto H, Okamoto A, Imanishi K, Tokui N, Okamoto T, Suzuki Y, Sugiyama N, Imai A, Kudo S, Yoneyama T, Hashimoto Y, Koie T, Kamimura N, Saitoh H, Funyu T, hyama C
  • Journal Title: Int. J Nephrol Volume: 2012 Pages: 1-7
  • DOI: 10.1155/2012/385274
  • Peer Reviewed
• [Journal Article] Minimum incision endoscopic radical cystectomy in patients with malignant tumors of the urinary bladder: clinical and oncological outcomes at a single institution. (2012)
  • Author(s): Koie T, Ohyama C, Yamamoto H, Hatakeyama S, Kudoh S, Yoneyama T, Hashimoto Y, Kamimura N.
  • Journal Title: Eur J Surg Oncol Volume: 38 Issue: 11 Pages: 1101-5
  • DOI: 10.1016/j.ejso.2012.07.115
• [Journal Article] Efficacies and safety of neoadjuvant gemcitabine plus carboplatin followed by immediate cystectomy in patients with muscle-invasive bladder cancer, including those unfit for cisplatin: a prospective single-arm study. (2012)
  • Author(s): Koie T, Ohyama C, Hashimoto Y, Hatakeyama S, Yamamoto H, Yoneyama T, Kamimura N.
  • Journal Title: Int J Clin Oncol. Volume: 19 Pages: 11-12
  • Peer Reviewed
• [Journal Article] Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease. (2012)
  • Author(s): Hatakeyama S, Yamamoto H, Okamoto A, Imanishi K, Tokui N, Okamoto T, Suzuki Y, Sugiyama N, Imai A, Kudo S, Yoneyama T, Hashimoto Y, Koie T, Kaminura N, Saitoh H, Funyu T, Ohyama C.
  • Journal Title: Int J Nephrol Volume: 2012
  • Peer Reviewed
• [Journal Article] A switch from conventional twice-daily tacrolimus to once-daily extended-release tacrolimus in stable kidney transplant recipients. (2012)
  • Author(s): Hatakeyama S, Fujita T, Yoneyama T, Yoneyama T, Koie T, Hashimoto Y, Saitoh H, Funyu T, Narumi S,Ohyama C.
  • Journal Title: Transplant Proc. Volume: 44 Issue: 1 Pages: 121-3
  • DOI: 10.1016/j.transproceed.2011.11.022
  • Peer Reviewed
• [Journal Article] Genomic profiling of renal cell carcinoma in patients with end-stage renal disease (2012)
  • Author(s): Inoue T, et al
  • Journal Title: Cancer science Volume: 103 Issue: 3 Pages: 569-576
  • DOI: 10.1111/j.1349-7006.2011.02176.x
  • Peer Reviewed
• [Journal Article] Clearance and safety of the radiocontrast medium iopamidol in peritoneal dialysis patients. (2012)
  • Author(s): Hatakeyama S, Abe A, Suzuki T, Hashimoto Y, Koie T, Funyu T, Satoh S, Habuchi T, Ohyama C, Matsuo S.
  • Journal Title: Int J Nephrol Volume: 2012 Pages: 1-6
  • DOI: 10.4061/2011/657051
  • Peer Reviewed
• [Journal Article] Carboplatin-gemcitabine combination chemotherapy upregulates AKR1B10 expression in bladder cancer (2011)
  • Author(s): Hashimoto Y, Imanishi K, Tokui N, Okamoto T, Okamoto A, Hatakeyama S, Yoneyama T, Koie T, Kamimura N, Ohyama C
  • Journal Title: Int J Clin Oncol Volume: 18 Issue: 1 Pages: 177-182
  • DOI: 10.1007/s10147-011-0363-7
  • NAID: 10031176252
  • Peer Reviewed
• [Journal Article] Biochemical outcome of small-volume or insignificant prostatecancer treated with radical prostatectomy in Japanese population (2011)
  • Author(s): Hashimoto Y, Okamoto A, Imai A, Yoneyama T, Hatakeyama S, Yoneyama T, Koie T, Kaminura N, Ohyama C
  • Journal Title: Int. J. Clin. Oncol Volume: 17 Issue: 2 Pages: 119-127
  • DOI: 10.1007/s10147-011-0267-6
  • Peer Reviewed
• [Journal Article] Efficacy of SMART Stent Placement for Salvage Angioplasty in Hemodialysis Patients with Recurrent Vascular Access Stenosis (2011)
  • Author(s): Hatakeyama S, Toikawa T, Okamoto A, Yamamoto H, Imanishi K, Okamoto T, Tokui N, Suzuki Y, Sugiyama N, Imai A, Hashimoto Y, Kudo S, Yoneyama T, Koie T, Kamimura N, Saitoh H, Funyu T, Ohyama C
  • Journal Title: Int J Nephrol Volume: 2011 Pages: 1-6
  • DOI: 10.4061/2011/464735
  • Peer Reviewed
• [Journal Article] An aggressive signet ring cell carcinoma of the prostate in a Japanese man (2011)
  • Author(s): Hashimoto Y, Imanishi K, Okamoto A, Sasaki A, Saitoh H, Wada R, Yamamoto H, Koie T, Ohyama C
  • Journal Title: Case Rep Oncol Volume: 4 Issue: 3 Pages: 517-520
  • DOI: 10.1159/000334081
  • Peer Reviewed
• [Journal Article] Targeted drug delivery to tumor vasculature by a carbohydrate mimetic peptide (2011)
  • Author(s): Hatakeyama S, Sugihara K, Shibata TK, Nakayama J, Akama TO, Tamura N, Wong S, Bobkov AA, Takano Y, Ohyama C, Fukuda M, Fukuda MN
  • Journal Title: Proc Natl Acad Sci USA Volume: 108 Issue: 49 Pages: 19587-19592
  • DOI: 10.1073/pnas.1105057108
  • Peer Reviewed
• [Journal Article] A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans (2011)
  • Author(s): 坪井滋、盛和行, 他
  • Journal Title: EMBO J Volume: 30(15) Issue: 15 Pages: 3173-3185
  • DOI: 10.1038/emboj.2011.215
  • Peer Reviewed
• [Journal Article] Requirement for FBP17 in invadopodia formation by invasive bladder tumor cells (2011)
  • Author(s): Yamamoto, H., Sutoh, M., Hatakeyama,S., Hashimoto, Y.,Yoneyama, T., Koie, T.,Saitoh, H., Yamaya, K., Funyu, T.,Nakamura, T., Ohyama, C. and Tsuboi,S.
  • Journal Title: Journal of Urology Volume: 185 Issue: 5 Pages: 1930-1938
  • DOI: 10.1016/j.juro.2010.12.027
  • Peer Reviewed
• [Presentation] 生体腎移植ドナー腎採取術3 術式間の比較検討 (2014)
  • Author(s): 畠山真吾，米山高弘，橋本安弘，古家琢也，大山 力
  • Organizer: 第28回日本泌尿器内視鏡学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-26 – 2014-11-28
• [Presentation] ミニマム創手術とダビンチ手術のメリット・デメリット：前立腺全摘除術、膀胱全摘除術の考察． (2014)
  • Author(s): 畠山真吾，米山高弘，橋本安弘，古家琢也，大山 力
  • Organizer: 第79回日本泌尿器科学会東部総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-10-12 – 2014-10-14
• [Presentation] Significance of serum N-glycan alteration associated with antibody mediated rejection in renal transplant recipients detected by High-throughput glycan analysis (2014)
  • Author(s): Hatakeyama S, Saito M, Inoue T, Tobisawa Y, Yoneyama T, Tuchiya N, Satoh S, Habuchi T, Ohyama C
  • Organizer: Hirosaki International Symposium on Transplant 2014
  • Place of Presentation: Hirosaki
  • Year and Date: 2014-08-31
• [Presentation] A switch from conventional twice-daily tacrolimus to once-daily tacrolimus extended-release in stable kidney transplant recipients. (2014)
  • Author(s): Hatakeyama S, Fujita T, Yoneyama T, Yoneyama T, Koie T, Hashimoto Y, Saitoh H, Funyu T, Narumi S, Ohyama C
  • Organizer: Hirosaki International Symposium on Transplant 2014
  • Place of Presentation: Hirosaki
  • Year and Date: 2014-08-31
• [Presentation] Outcome comparison of abo-incompatible kidney transplantation with low dose rituximab and abo-compatible kidney transplantation: A single-center experience. (2014)
  • Author(s): Hatakeyama S, Fujita T, Murakami R, Suzuki Y, Sugiyama N, Yamamoto H, Okamoto A, Imai A, Tobisawa Y, Yoneyama T, Mori K, Yoneyama T, Koie T, Hashimoto Y, Narumi S, Ohyama C
  • Organizer: Hirosaki International Symposium on Transplant 2014
  • Place of Presentation: Hirosaki
  • Year and Date: 2014-08-31
• [Presentation] Post-transplant renal function and cardiovascular events are closely associated with the aortic calcification index (ACI) in renal transplant recipients. (2014)
  • Author(s): Hatakeyama S, Imanishi K, Yamamoto H, Okamoto A, Imai A, Yoneyama T, Hashimoto Y, Koie T, Fujita T, Murakami R, Saitoh H, Funyu T, Narumi S, Ohyama C
  • Organizer: Hirosaki International Symposium on Transplant 2014
  • Place of Presentation: Hirosaki
  • Year and Date: 2014-08-31
• [Presentation] BK virus-associated urothelial carcinoma of a ureter graft in a renal transplant recipient : a case report. (2014)
  • Author(s): Oikawa M, Hatakeyama S, Fujita T, Murakami R, Hagiwara K, Narita T, Noro D, Tanaka T, Tanaka Y, Tobisawa Y, Yoneyama T, Yoneyama Y, Hashimoto Y, Koie T, Narumi S, Ohyama C
  • Organizer: Hirosaki International Symposium on Transplant 2014
  • Place of Presentation: Hirosaki
  • Year and Date: 2014-08-31
• [Presentation] 透析腎癌スクリーニング検査の有用性と限界についての検討 (2014)
  • Author(s): 畠山真吾，岡本亜希子，米山高弘，橋本安弘，大山 力，齋藤久夫，舟生富寿
  • Organizer: 第41回東北腎不全研究会
  • Place of Presentation: 秋田
  • Year and Date: 2014-08-30 – 2014-08-31
• [Presentation] 生体腎移植ドナー術後の腎機能についての検討． (2014)
  • Author(s): 畠山真吾，藤田 雄，村上礼一，山本勇人，今井 篤，米山高弘，橋本安弘，古家琢也，大山 力
  • Organizer: 第30回腎移植・血管外科研究会
  • Place of Presentation: 那覇
  • Year and Date: 2014-06-27 – 2014-06-28
• [Presentation] 透析腎癌における画像診断の限界についての検討 (2014)
  • Author(s): 畠山真吾，岡本亜希子，工藤茂将，米山高弘，橋本安弘，斎藤久夫，大山 力，舟生富寿
  • Organizer: 第59回日本透析医学会学術集会・総会
  • Place of Presentation: 神戸
  • Year and Date: 2014-06-12 – 2014-06-15
• [Presentation] Post-transplant renal function is closely correlated with aortic calcification index (ACI) progression rate in renal transplant recipients. (2014)
  • Author(s): Hatakeyama S, Yoneyama T, Koie T, Fujita T, Murakami R, Saito H, Narumi S, Funyu T, Ohyama C
  • Organizer: 第109回米国泌尿器学会議
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2014-05-16 – 2014-05-21
• [Presentation] Prognostic benefit of surgical management in RCC patients with thrombus extending to the renal vein and inferior vena cava: a propensity score matched analysis. (2014)
  • Author(s): Hatakeyama S, Yoneyama T, Yamamoto H, Imai A, Hashimoto Y, Koie T, Ohyama C
  • Organizer: 第109回米国泌尿器学会議
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2014-05-16 – 2014-05-21
• [Presentation] Safety of heparin bridging therapy for transrectal ultrasound-guided prostate biopsy (TRUS-Pb) in patients requiring temporary discontinuation of warfarin. (2014)
  • Author(s): Hamano I, Hatakeyama S, Kusaka A, Imanishi K, Tokui N, Okamoto T, Yamamoto H, Imai A, Yoneyama T, Hashimoto Y, Koie T, Ohyama C
  • Organizer: 第109回米国泌尿器学会議
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2014-05-16 – 2014-05-21
• [Presentation] BMI38の症例に対して行ったロボット支援下膵体尾部切除+腎切除の経験． (2014)
  • Author(s): 畠山真吾，山本勇人，岡本亜希子，今井 篤，米山高弘，橋本安弘，古家琢也，石戸圭之輔，袴田健一，大山 力
  • Organizer: 第102回日本泌尿器科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 膀胱全摘か温存療法か？高齢者の筋層浸潤膀胱癌についての検討 (2014)
  • Author(s): 畠山真吾，杉山尚樹，鈴木裕一朗，山本勇人，今井 篤，岡本亜希子，米山高弘，橋本安弘，古家琢也，大山 力
  • Organizer: 第102回日本泌尿器科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 尿酸成分を有する結石は慢性腎臓病(CKD)のリスク因子である (2014)
  • Author(s): 畠山真吾，寺山百合子，齋藤文匡，齋藤久夫，橋本安弘，古家琢也，舟生富壽，大山 力
  • Organizer: 第102回日本泌尿器科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] Radiologic response predict prognosis in patients with muscle-invasive bladder cancer undergoing carboplatin-based neoadjuvant chemotherapy. (2014)
  • Author(s): Hatakeyama S, Yamamoto H, Okamoto A, Imai A, Yoneyama T, Hashimoto Y, Koie T, Ohyama C
  • Organizer: 第29回欧州泌尿器科学会
  • Place of Presentation: Stockholm
  • Year and Date: 2014-04-11 – 2014-04-15
• [Presentation] Presence of transient hydronephrosis immediately after surgery has limited influence on renal function at one year after ileal neobladder construction. (2014)
  • Author(s): Narita T, Hatakeyama S, Koie T, Yamamoto H, Imai A, Yoneyama T, Hashimoto Y, Ohyama C
  • Organizer: 第29回欧州泌尿器科学会
  • Place of Presentation: Stockholm
  • Year and Date: 2014-04-11 – 2014-04-15
• [Presentation] Clinical and pathological characteristics of the patients in spite of positive surgical margins who were free from biochemical recurrence after radical prostatectomy (2014)
  • Author(s): Hatakeyama S, Mitsuzuka K, Narita S, Koie T, Yoneyama T, Hashimoto Y, Tsuchiya N, Kawamura S, Habuchi T, Arai Y, Ohyama C
  • Organizer: 第29回欧州泌尿器科学会
  • Place of Presentation: Stockholm
  • Year and Date: 2014-04-11
• [Presentation] T stagingが困難であったHigh Risk前立腺癌の2例 (2014)
  • Author(s): 62. 畠山真吾，日下 歩，濱野逸人，村澤洋美，得居範子，今西賢悟，山本勇人，今井 篤，米山高弘，橋本安弘，古家琢也，大山 力
  • Organizer: 第18回青森前立腺癌研究会
  • Place of Presentation: 青森市（ねぶたの家ワ・ラッセ）
• [Presentation] Aberrant glycosylation of N-glycan on Immunoglobulin closely relates survival of the patients with in renal cell carcinoma (2013)
  • Author(s): Hatakeyama S, Tobisawa Y, Yoneyama T, Suzuki Y, Yamamoto H, Mori K, Yoneyama T, Hashimoto Y, Koie T, Tsuchiya N, Habuchi T, Amano M, Nishimura S, Ohyama C
  • Organizer: 2013年米国泌尿器科学会議
  • Place of Presentation: サンディエゴ、USA
• [Presentation] Do types of urinary diversion affect renal function deterioration? (2013)
  • Author(s): Hatakeyama S, Sugiyama N, Suzuki Y, Okamoto A, Yamamoto H, Imai A, Yoneyama T, Hashimoto Y, Koie T, Ohyama C
  • Organizer: 2013年米国泌尿器科学会議
  • Place of Presentation: サンディエゴ、USA
• [Presentation] Low percentage (<10%) of positive biopsy core (PBC) is not a predictor of lower risk for PSA recurrence in cT1c prostate cancer treated with radical prostatectomy in contemporary Japanese population (2013)
  • Author(s): Hatakeyama S, Yoneyama T, Hashimoto Y, Koie T, Narita S, Tsuchiya N, Mitsuzuka K, Kawamura S, Habuchi T, Arai Y, Ohyama C
  • Organizer: 2013年米国泌尿器科学会議
  • Place of Presentation: サンディエゴ、USA
• [Presentation] Outcomes of ABO-incompatible kidney transplantation with low dose rituximab compared with ABO-compatible kidney transplantation: a single-center experience (2013)
  • Author(s): Hatakeyama S, Suzuki Y, Sugiyama N, Yamamoto H, Okamoto A, Imai A, Tobisawa Y, Yoneyama To, Mori K, Fujita T, Murakami R, Yoneyama Ta, Hashimoto Y, Koie T, Narumi S, Ohyama C
  • Organizer: 第13回アジア移植学会
  • Place of Presentation: 京都市（国立京都国際会館）
• [Presentation] 腎細胞感における血清免疫グロブリンの糖鎖変異についての検討 (2013)
  • Author(s): 畠山真吾，米山 徹，飛澤悠葵，盛 和行，米山高弘，橋本安弘，古家琢也，天野麻穂，西村紳一郎，大山 力
  • Organizer: 第101回日本泌尿器科学会総会
  • Place of Presentation: 札幌市（さっぽろ芸術文化の館）
• [Presentation] 75歳以上の高齢者における筋層湿潤膀胱癌についての検討 (2013)
  • Author(s): 畠山真吾，杉山尚樹，鈴木裕一朗，山本勇人，今井 篤，岡本亜希子，米山高弘，橋本安弘，古家琢也，大山 力
  • Organizer: 第101回日本泌尿器科学会総会
  • Place of Presentation: 札幌市（ロイトン札幌）
• [Presentation] 塩酸セベラマーからビキサロマーへの切り替えによる透析患者の消化器形状と便形状変化についての検討 (2013)
  • Author(s): 畠山真吾，村澤洋美，岡本亜希子，米山高弘，橋本安弘，石村大史，佐々木淳，齋藤久夫，舟生富寿，大山 力
  • Organizer: 第58回日本透析医学会学術集会
  • Place of Presentation: 福岡市（マリンメッセ福岡）
• [Presentation] 再発する内シャント狭窄に対する血管内ステントの有効性について (2013)
  • Author(s): 畠山真吾，及川真亮，萩原和久，鈴木裕一朗，杉山尚樹，山本勇人，岡本亜希子，今井 篤，米山高弘，橋本安弘，古家琢也，斎藤久夫，舟生富寿，大山 力
  • Organizer: 第29回腎移植・血管外科研究会
  • Place of Presentation: 青森市（浅虫温泉 海扇閣・南部屋）
• [Presentation] 科におけるABO 不適合腎移植の治療成績 (2013)
  • Author(s): 畠山真吾，藤田 雄，村上礼一，鈴木裕一朗，杉山尚樹，山本勇人，岡本亜希子，今井 篤，盛 和行，米山高弘，橋本安弘，古家琢也，舟生富寿，大山 力
  • Organizer: 第29回腎移植・血管外科研究会
  • Place of Presentation: 青森市（浅虫温泉 海扇閣・南部屋）
• [Presentation] 抗凝固薬内服患者に対するヘパリンブリッジ前立腺生検の安全性についての検討 (2013)
  • Author(s): 畠山真吾，濱野逸人，日下 歩，今西賢悟，得居範子，岡本哲平，山本勇人，岡本亜希子，今井 篤，米山高弘，橋本安弘，古家琢也，大山 力
  • Organizer: 第78回日本泌尿器科学会東部総会
  • Place of Presentation: 新潟市（朱鷺メッセ・新潟コンベンションセンター）
• [Presentation] 当科における低用量リツキシマブ単回投与によるABO不適合腎移植の治療成績 (2013)
  • Author(s): 畠山真吾，藤田 雄，村上礼一，山本勇人，岡本亜希子，今井 篤，盛 和行，米山高弘，橋本安弘，古家琢也，大山 力
  • Organizer: 第16回東北移植研究会
  • Place of Presentation: 仙台市（TKP仙台カンファレンスセンター）
• [Presentation] BMI38 の症例に対して行ったロボット支援下膵体尾部切除＋腎部分切除 (2013)
  • Author(s): 畠山真吾，石戸敬之輔、山本勇人，岡本亜希子，今井 篤，米山高弘，橋本安弘，古家琢也，袴田健一，大山 力
  • Organizer: 第27回日本泌尿器内視鏡学会総会
  • Place of Presentation: 名古屋市（ウェスティンナゴヤキャッスル
• [Presentation] 腎移植におけるタクロリムス徐放製剤への切り替え経験 (2013)
  • Author(s): 畠山真吾，村澤洋美，得居範子，山本勇人，岡本亜希子，今井 篤，米山高弘，古家琢也，橋本安弘，石村大史，斎藤久夫，舟生富寿，大山 力
  • Organizer: 第33回北海道腎移植談話会
  • Place of Presentation: 札幌市（札幌市立大学）
• [Presentation] 海外主要学会の最新トピックス (2013)
  • Author(s): 畠山真吾
  • Organizer: 弘前泌尿器科セミナー弘前
  • Place of Presentation: 弘前市（ベストウェスタンニューシティ弘前）
• [Presentation] Low percentage (≤10%) of positive biopsy core (PBC) is not a predictor of lower risk for PSA recurrence in cT1c prostate cancer treated with radical prostatectomy in contemporary Japanese population. (2013)
  • Author(s): Hatakeyama S, Koie T, Yoneyama Ta, Hashimoto Y, Narita S, Tsuchiya N, Habuchi T, Mitsuzuka K, Kawamura S, Arai Y, Ohyama C
  • Organizer: EAU （European Association of Urology） 2013
  • Place of Presentation: ミラノ、イタリア
• [Presentation] Post-transplant renal function is closely correlated with aortic calcification index (ACI) progression rate in renal transplant recipients. (2013)
  • Author(s): Hatakeyama S, Yoneyama Ta, Koie T, Fujita T, Murakami R, Saito H, Narumi S, Funyu T, Ohyama C
  • Organizer: EAU （European Association of Urology） 2013
  • Place of Presentation: ミラノ、イタリア
• [Presentation] Type of androgen deprivation therapy affects metabolic condition and adipose tissue distribution． (2012)
  • Author(s): Hatakeyama S, Yamamoto H, Murasawa H, Okamoto A, Imai A, Yoneyama Takahiro, Hashimoto Y, Koie T, Kamimura N, Ohyama C
  • Organizer: 第 32 回国際泌尿器科学会総会（SIU）
  • Place of Presentation: 福岡市、福岡県
• [Presentation] Serum N-glycan profiling has potential to predict cardiovascular disease (CVD) event and prognosis in hemodialysis (HD) patients. (2012)
  • Author(s): Hatakeyama S, Tsusihma M, Amano M, Yoneyama Tohru, Tobisawa Y, Nishimura S, Ohyama C
  • Organizer: Glycobiology Meeting 2012
  • Place of Presentation: サンディエゴ、USA
• [Presentation] 年 1 回の CT スク リーニングによる透析腎癌の発見率と転帰． (2012)
  • Author(s): 畠山真吾，鈴木裕一朗，杉山尚樹，山本勇人，今井 篤，工藤茂将，米山高弘，橋 本安弘，古家琢也，神村典孝，斎藤久夫，舟生富壽，大山 力
  • Organizer: 第 100 回日本泌尿器科学会総会
  • Place of Presentation: 横浜市、神奈川県
• [Presentation] Types of urinary diversion have no impact on eGFR decreasing rate (2012)
  • Author(s): Shingo Hatakeyama, Hayato Yamamoto, Shigemasa Kudo, Takahiro Yoneyama, Takuya Koie, Kamimura Noritaka, Chikara Ohyama
  • Organizer: 27th EAU annual congress
  • Place of Presentation: Paris
• [Presentation] Incidence and oncologic outcome of renal cell carcinoma (RCC) in hemodialysis (HD) patients detected by annual computed tomography (CT) screening (2012)
  • Author(s): Shingo Hatakeyama, Yuichiro Suzuki2, Hayato Yamamoto, Shigemasa Kudo, Takahiro Yoneyama, Takuya Koie, Noritaka Kamimura, Hisao Saitoh, Tomihisa Funyu, Chikara Ohyama
  • Organizer: 27th EAU annual congress
  • Place of Presentation: Paris
• [Presentation] EXPRESSION OF LAMININ-BINDING GLYCANS ON &a-DYSTROGLYCAN CORRELATES WITH TUMOR SUPPRESSOR FUNCTION IN PROSTATE CANCER (2011)
  • Author(s): Shingo Hatakeyama, Xingfeng Bao, Noriko Tokui, et al.
  • Organizer: 106th AUA annual meeting
  • Place of Presentation: Washington DC
• [Presentation] HIGH THROUGH PUT, COMPREHENSIVE AND QUANTITATIVE GLYCOMICS OF WHOLE SERUM GLYCOPROTEINS FOR DIAGNOSIS OF RENAL CELL CARCINOMA (2011)
  • Author(s): Shingo Hatakeyama, Maho Amano, Megumi Tsushima, Hatato Yamamoto, et al.
  • Organizer: 106th AUA annual meeting
  • Place of Presentation: Washington DC
• [Presentation] Switching from conventional twice-daily tacrolimus (TAC) to once-daily tacrolimus extended-release (TAC-ER) in stable kidney transplant recipients (2011)
  • Author(s): Shingo Hatakeyama, Takeshi Fujita, Tohru Yoneyama, Takahiro Yoneyama, Takuya Koie, Yasuhiro Hashimoto, Hisao Saitoh, Tomihisa Funyu, Shunji Narumi, Chikara Ohyama
  • Organizer: Congress of Asian Society of Transplantation
  • Place of Presentation: Seoul, Korea
• [Presentation] 腎細胞癌における血清糖タンパク糖鎖の網羅的解析 (2011)
  • Author(s): 畠山真吾 、鈴木裕一朗 、杉山尚樹 、米山 徹 、盛 和行 、山本勇人、對馬惠、岡本亜希子 、齋藤久夫、舟生富壽、 天野麻穂 、西村 紳一郎、土谷順彦、羽渕友則 、大山 力
  • Organizer: 99th 日本泌尿器科学会総会
  • Place of Presentation: 名古屋
• [Book] Methods Mol Biol. 2013 (2013)
  • Author(s): Hatakeyama S, Shibata TK, Tobisawa Y, Ohyama C, Sugihara K, Fukuda MN
  • Total Pages: 16
  • Publisher: Humana Press
• [Remarks] 平 成 24 年度（2012 年）業績
  • URL: http://www.med.hirosaki-u.ac.jp/~uro/html/Research-Publications/2012business-productivity.pdf
• [Patent(Industrial Property Rights)] 腎細胞癌の判定法 (2013)
  • Inventor(s): 畠山真吾
  • Industrial Property Rights Holder: 畠山真吾
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2011-532971
  • Filing Date: 2013-08-05
  • Overseas