The role of insulin signaling in the mechanism of androgen independent prostate cancer
| Project/Area Number |
23791738
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Akita University |
|---|
Principal Investigator |
INOUE Takamitsu 秋田大学, 大学院・医学研究科, 講師 (60375243)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 腫瘍学 / インスリンシグナル / 腎癌 / メタボリックシンドローム / メトフォルミン / インスリン抵抗性 / 無病生存期間 / インスリン / メタボリック症候群 / RENCA / mTOR / AMPK / ラパマイシン |
|---|
| Research Abstract |
Hyperinsulinemia resulted from high carbohydrate diet acceralated the progression of murine renal cell carcinoma. Metformin inhibited the progression of murine renal cell carcinoma due to improvement of hyperinsulinemia and/or direct tumor inhibitory effect. Insulin receptor overexpresssion was independent predictor of a favorable outcome in patients with renal cell carcinoma who underwent radical or partial nephrectomy.
|
Report
(3 results)
Research Products
(9 results)
-
-
-
-
-
[Presentation] In vivo castration-resistant acceleration of prostate cancer inhibited by a small molecule inhibitor of insulin-like growth factor 1 receptor/insulin receptor tyrosine kinase2011
Author(s)
Inoue, T., Zakikhani, M., Mireuta, M., Blouin, MJ., Pollak, M.
Organizer
The 106th Annunal Meeting of the American Urological Association
Place of Presentation
Washisnton DC, USA
Related Report
-
-
-
-
