Mechanisms of high-fat induced prostate cancer progression through Monocyte Chemotactic Protein-1 secreted by adipose tissue
Project/Area Number |
23791739
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | Akita University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 前立腺癌 / 肥満 / 高脂肪 / Monocyte Chemotactic Protein-1 / MCP-1 / 高脂肪食 |
Research Abstract |
We investigated the effects of different diets on prostate cancer cell growth and the relevant circulating factors including serum insulin, growth factors, and inflammatory cytokines using the in vivo and ex vivo model. The tumor growth of prostate cancer LNCaP xenograft was significantly higher in the HFD group than in the HCD and control diet (CD) groups. The mean level of the serum monocyte chemoattractant protein-1 (MCP-1) in the HFD group was significantly higher than that in the HCD and CD groups. The mRNA levels of CC chemokine receptor 2 (CCR2), which is an MCP-1 receptor, and the expression of activated Akt were the highest in the HFD group. Furthermore, serum from HFD-fed mice enhanced the proliferation of two PCa cells and CCR2 knockdown inhibited HFD-induced proliferation of LNCaP cells. In conclusion, an HFD enhanced prostate cancer cell growth more strongly than an HCD or CD. MCP-1/CCR2 signaling may be involved in an HFD-induced prostate cancer progression.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] A high-fat diet enhances proliferation of prostate cancer cells and activates MCP-1/CCR2 signaling2012
Author(s)
Huang, M., Narita, S., Numakura, K., Tsuruta, H., Saito, M., Inoue, T., Horikawa, Y., Tsuchiya, N.and Habuchi, T.
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Journal Title
Prostate
Volume: 72
Pages: 1779-1788
Related Report
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[Journal Article] Overexpression of Fn14 promotes Androgen independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome2011
Author(s)
Huang, M., Narita, S., Tsuchiya, N., Ma Z., Numakura, K., Obara, T., Tsuruta, H., Saito, M., Inoue, T., Horikawa, Y., Satoh, S. and Habuchi, T.
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Journal Title
Carcinogenesis.
Volume: 32
Pages: 1589-96
Related Report
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[Presentation] Stimulation of macrophage inhibitory cytokine-1 by palmitic acid activates prostate cancer cell invasiveness2012
Author(s)
Mingguro, H., Narita, S., Maita, S., Numakura, K., Obara, T., Inoue, T., Horikawa, Y., Satoh, S.and Habuchi, T.
Organizer
The 107th annual meeting of the American Urological Association
Place of Presentation
Atlanta, USA
Related Report
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[Presentation] Prostate cancer progression under high fat diet is enhanced by the MCP-1/CCR2 signaling2011
Author(s)
Huang, M., Narita, S., Numakura, K., Tsuruta, H., Saito, M., Inoue, T., Horikawa, Y., Tsuchiya, N., Habuchi, T.
Organizer
The 106th Annunal Meeting of the American Urological Association
Place of Presentation
Washisnton DC, USA
Related Report
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