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Mechanisms of high-fat induced prostate cancer progression through Monocyte Chemotactic Protein-1 secreted by adipose tissue

Research Project

Project/Area Number 23791739
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionAkita University

Principal Investigator

SHINTARO Narita  秋田大学, 医学部, 講師 (40396552)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords前立腺癌 / 肥満 / 高脂肪 / Monocyte Chemotactic Protein-1 / MCP-1 / 高脂肪食
Research Abstract

We investigated the effects of different diets on prostate cancer cell growth and the relevant circulating factors including serum insulin, growth factors, and inflammatory cytokines using the in vivo and ex vivo model. The tumor growth of prostate cancer LNCaP xenograft was significantly higher in the HFD group than in the HCD and control diet (CD) groups. The mean level of the serum monocyte chemoattractant protein-1 (MCP-1) in the HFD group was significantly higher than that in the HCD and CD groups. The mRNA levels of CC chemokine receptor 2 (CCR2), which is an MCP-1 receptor, and the expression of activated Akt were the highest in the HFD group. Furthermore, serum from HFD-fed mice enhanced the proliferation of two PCa cells and CCR2 knockdown inhibited HFD-induced proliferation of LNCaP cells. In conclusion, an HFD enhanced prostate cancer cell growth more strongly than an HCD or CD. MCP-1/CCR2 signaling may be involved in an HFD-induced prostate cancer progression.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] A high-fat diet enhances proliferation of prostate cancer cells and activates MCP-1/CCR2 signaling2012

    • Author(s)
      Huang, M., Narita, S., Numakura, K., Tsuruta, H., Saito, M., Inoue, T., Horikawa, Y., Tsuchiya, N.and Habuchi, T.
    • Journal Title

      Prostate

      Volume: 72 Pages: 1779-1788

    • Related Report
      2012 Final Research Report
  • [Journal Article] A high-fat diet enhances proliferation of prostate cancer cells and activates MCP-1/CCR2 signaling.2012

    • Author(s)
      Huang M
    • Journal Title

      Prostate

      Volume: 72 Issue: 16 Pages: 1779-1788

    • DOI

      10.1002/pros.22531

    • Related Report
      2012 Annual Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Overexpression of Fn14 promotes Androgen independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome2011

    • Author(s)
      Huang, M., Narita, S., Tsuchiya, N., Ma Z., Numakura, K., Obara, T., Tsuruta, H., Saito, M., Inoue, T., Horikawa, Y., Satoh, S. and Habuchi, T.
    • Journal Title

      Carcinogenesis.

      Volume: 32 Pages: 1589-96

    • Related Report
      2012 Final Research Report
  • [Presentation] Stimulation of macrophage inhibitory cytokine-1 by palmitic acid activates prostate cancer cell invasiveness2012

    • Author(s)
      Mingguro, H., Narita, S., Maita, S., Numakura, K., Obara, T., Inoue, T., Horikawa, Y., Satoh, S.and Habuchi, T.
    • Organizer
      The 107th annual meeting of the American Urological Association
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] 前立腺癌進展における長鎖脂肪酸パルミチンの役割2012

    • Author(s)
      黄明国、成田伸太郎,井上高光,土谷順彦,佐藤滋,羽渕友則
    • Organizer
      第71回日本癌学会・総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] Prostate cancer progression under high fat diet is enhanced by the MCP-1/CCR2 signaling2011

    • Author(s)
      Huang, M., Narita, S., Numakura, K., Tsuruta, H., Saito, M., Inoue, T., Horikawa, Y., Tsuchiya, N., Habuchi, T.
    • Organizer
      The 106th Annunal Meeting of the American Urological Association
    • Place of Presentation
      Washisnton DC, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] サイトカインシグナルを介した高脂肪食摂取下の前立腺癌増殖機序の解明(ヤングリサーチグラント受賞者記念講演)2011

    • Author(s)
      成田伸太郎
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] Prostate cancer progression under high fat diet is enhanced by the MCP-1/CCR2 signaling2011

    • Author(s)
      Huang Mingguo
    • Organizer
      The 106th Annual Meeting of the American Urological Association
    • Place of Presentation
      Washington
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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