The effects of statin on prostate cancer progression via miRNA
| Project/Area Number |
23791741
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 腫瘍学 / 前立腺癌 / miRNA / スタチン / データベース |
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| Research Abstract |
Statins have been being studied for their proapoptic and antimetastatic effects. However, the exact mechanisms of their anticancer action are still unclear. In this study, we identified miRNAs affected by treatment of statins, and mRNAs, targeted by the identified miRNAs, which are concerned with progression of prostate cancer. In PC-3 cells, theexpressions of miR-210 and miR-375 were up-regulated by simvastatin. Moreover, INSIG1, which is a target of miR-210 and down-regulated by simvastatin, seemed to play a role in the antitumoral effects of statin.
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Report
(3 results)
Research Products
(2 results)
