The effects of statin on prostate cancer progression via miRNA

Research Project

Project/Area Number	23791741
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Urology
Research Institution	Gunma University
Principal Investigator	SEKINE Yoshitaka 群馬大学, 大学院・医学系研究科, 助教 (00516370)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	腫瘍学 / 前立腺癌 / miRNA / スタチン / データベース
Research Abstract	Statins have been being studied for their proapoptic and antimetastatic effects. However, the exact mechanisms of their anticancer action are still unclear. In this study, we identified miRNAs affected by treatment of statins, and mRNAs, targeted by the identified miRNAs, which are concerned with progression of prostate cancer. In PC-3 cells, theexpressions of miR-210 and miR-375 were up-regulated by simvastatin. Moreover, INSIG1, which is a target of miR-210 and down-regulated by simvastatin, seemed to play a role in the antitumoral effects of statin.

Report

(3 results)