Isolation of the bladder cancer-initiating cells (BCICs) and investigating the BCIC-targeting therapeutic strategy

• Project/Area Number: 23791744
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TATOKORO Manabu 東京医科歯科大学, 医学部附属病院, 助教 (00456237)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 泌尿器科学 / 腫瘍学 / 膀胱癌 / 癌幹細胞 / シスプラチン / 治療耐性

Research Abstract

Although many advanced bladder cancer patients show an initially good tumor response to systemic chemotherapy, most of them develop recurrences and eventually die from the disease. This phenomenon is attributable to the re-growth of bladder cancer-initiating cells (BCICs) that have survived chemotherapy. In this study, the authors have isolated BCICs, analyzed their chemo-sensitivity and investigated whether heat-shock protein 90 (Hsp90) inhibitors potentiate the chemo-cytotoxicity on BCICs.

Research Products

• [Journal Article] Potential role of Hsp90 inhibitors in overcoming cisplatin resistance of bladder cancer-initiating cells (2012)
  • Author(s): Tatokoro M, Koga F, Yoshida S, Kawakami S, Fujii Y, Neckers L, Kihara K
  • Journal Title: Int J Cancer Volume: 131 Issue: 4 Pages: 987-96
  • DOI: 10.1002/ijc.26475
  • Peer Reviewed
• [Presentation] 膀胱癌幹細胞のシスプラチン抵抗性と,Heat shock protein 90 阻害剤による抵抗性克服 (2012)
  • Author(s): 田所学、古賀文隆、吉田宗一郎、福島啓司、川上理、藤井靖久、Len Neckers、木原和徳
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-04-21
• [Presentation] Potential role of Hsp90 Inhibitors in overcoming cisplatin resistance of bladder cancer stem cells (2012)
  • Author(s): 田所学、古賀文隆、吉田宗一郎、川上理、藤井靖久、Len Neckers、木原和徳
  • Organizer: 第27回欧州泌尿器科学会年次総会
  • Place of Presentation: フランス、パリ
  • Year and Date: 2012-02-26
• [Presentation] 膀胱癌幹細胞のシスプラチン抵抗性と，Heat shock protein 90 阻害剤による抵抗性克服． (2012)
  • Author(s): 田所 学
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: 横浜
• [Presentation] Potential role of Hsp90 Inhibitors in overcoming cisplatin resistance of bladder cancer stem cells (2012)
  • Author(s): 田所 学
  • Organizer: 27th Annual european association of urology congress
  • Place of Presentation: パリ