The evaluation of S100-family proteins in urotherial cancer.

• Project/Area Number: 23791750
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: SUGIYAMA Takayuki 浜松医科大学, 医学部, 助教 (70444346)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 尿路上皮癌 / S100 ファミリー蛋白 / S1100A2 / 膀胱がん / S100蛋白

Research Abstract

The aim of the present study is to evaluate the expression level S100A2 mRNA in human bladder cancer. In cultured cell, T24 (p53-mutant) expressed S100A2mRNA, but there were little difference for S100A4mRNA expression. H1299 (p53-null) showed diminished expression of S1000A4. We showed the diminished expression of S100A2mRNA in human clear cell RCC, but all bladder cancer cases had the expression of S100A2mRNA. We couldn’ t find any correlation the expression of S100A2 and clinicopathological factors.S100A10 seem to be low expression level in invasive cases, especially above T2 stage.

Research Products

• [Presentation] 当科における膀胱全摘除術の臨床的検討 (2012)
  • Author(s): 洋,谷島崇史,田村啓多,加藤大貴,鈴木孝尚,甲斐文丈,杉山貴之,永田仁夫,大塚篤史,高山達也,石井保夫,平野恭弘,栗田 豊,麦谷荘一,大園誠一郎
  • Organizer: 第50回日本癌治療学会学術集会
  • Year and Date: 2012-10-26
• [Presentation] 早期腎細胞癌におけるS100A4mRNA発現の検討 (2012)
  • Author(s): 杉山貴之,高山達也,宮崎美紀,甲斐文丈,麦谷荘一,大園誠一郎
  • Organizer: 第50回日本癌治療学会学術集会
  • Year and Date: 2012-10-25
• [Presentation] Evaluation of the Expression of S-100A2 mRNA in Human Bladder Cancer. (2012)
  • Author(s): Sugiyama T, Takayama T, Miyazaki M, Furuse H, Mugiya S, Ozono S
  • Organizer: 第32回国際泌尿器科学会総会
  • Year and Date: 2012-10-01
• [Presentation] 胃癌治療中縮小を見た再発膀胱腫瘍の 1例 (2012)
  • Author(s): 谷島崇史, 杉山貴之,高山達也,鈴木孝尚,甲斐文丈,永田仁夫,大塚篤史,石井保夫,古瀬 洋,麦谷荘一,大園誠一郎
  • Organizer: 第257回日本泌尿器科学会東海地方
  • Year and Date: 2012-09-08
• [Presentation] 人間ドック受診者における泌尿器癌と喫煙との関係 (2012)
  • Author(s): 野畑俊介,木内正太郎,渡辺めぐみ,臼田多佳夫,森 厚嘉,福田崇典,杉山貴之,永田仁夫,高山達也,古瀬 洋,麦谷荘一,大園誠一郎
  • Organizer: 第21回日本腎泌尿器疾患予防医学研究会
  • Year and Date: 2012-07-13
• [Presentation] 膀胱尿路上皮癌 Nested variant の 1 例 (2012)
  • Author(s): 加藤大貴,鈴木孝尚,大塚篤史,谷島崇史,田村啓多,甲斐文丈,杉山貴之,永田仁夫,高山達也,石井保夫,古瀬 洋,麦谷荘一,大園誠一郎
  • Organizer: 第256回日本泌尿器科学会東海地方会
  • Year and Date: 2012-06-09
• [Presentation] 膀胱癌乳腺転移の 1 例 (2012)
  • Author(s): 甲斐文丈,永田仁夫,田村啓多,加藤大貴,鈴木孝尚,杉山貴之,大塚篤史,高山達也,石井保夫,古瀬洋,麦谷荘一,大園誠一郎,伊藤寿樹
  • Organizer: 第255回日本泌尿器科学会東海地方会
  • Year and Date: 2012-03-11
• [Presentation] Evaluation of the expression alevels of S100A2 mRNA in renal cell carcinoma (2012)
  • Author(s): Sugiyama T
  • Organizer: 2012 Genitourinary Cancers Symposium
  • Year and Date: 2012-02-04
• [Presentation] Evaluation of the expression of S100A2 mRNA in human bladder carcinoma (2012)
  • Author(s): Sugiyama T, Takayama T, Miyazaki M, Furruse H, Mugiya S, Ozono S
  • Organizer: 第32回国際泌尿器科学会総会
  • Place of Presentation: 福岡市
• [Presentation] Evaluation of the expression levels of S-100A2 mRNA in human renal cell carcinoma (2012)
  • Author(s): 杉山貴之
  • Organizer: 2012 Genitourinary Cancers Symposium
  • Place of Presentation: サンフランシスコ
• [Presentation] 当科で経験した透析患者の尿路上皮腫瘍の検討 (2011)
  • Author(s): 杉山貴之,高山達也,松本力哉,鈴木孝尚,伊藤寿樹,永田仁夫,大塚篤史,古瀬 洋,麦谷荘一,大園誠一郎
  • Organizer: 第56回(社)日本透析医学会学術集会・総会
  • Year and Date: 2011-06-18