Blocking of CCR5 and CXCR3 Suppresses Acute and Chronic Renal Allograft Rejection
Project/Area Number |
23791753
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | Osaka University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 腎移植 / 拒絶反応 / ケモカイン / 国際情報交流 |
Research Abstract |
A combined therapy involving cyclosporin A (CsA) and CCR5/CXCR3 antagonistresulted in decreased macrophage infiltration, and graft survival was substantiallyprolonged in a rat kidney transplant model. The dual blocking of CCR5/CXCR3 can beuseful in decreasing rejection. This mechanism acts, not only to block T cell recruitment to a kidney graft but also to suppress the infiltration of macrophages to tubules, which leads to tubulitis. Thus, the dual blocking of both receptors has the potential to serve as a new therapeutic target in the future.
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Report
(3 results)
Research Products
(41 results)
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[Journal Article] Hepatocyte growth factor sustains T regulatory cells and prolongs the survival of kidney allografts in major histocompatibility complex-inbred CLAWN-miniature swine2012
Author(s)
Oku M, Okumi M, Shimizu A, Sahara H, Setoyama K, Nishimura H, Sada M, Scalea J, Ido A, Sachs DH, Tsubouchi H, Yamada K.
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Journal Title
Transplantation
Volume: 93
Pages: 148-55
Related Report
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[Journal Article] Carbamylated erythropoietin ameliorates cyclosporine nephropathy without stimulating erythropoiesis2012
Author(s)
Abe T, Isaka Y, Imamura R, Kakuta Y, Okumi M, Yazawa K, Ichimaru N, Tsuda H, Nonomura N, Takahara S, Okuyama A.
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Journal Title
Cell Transplant
Volume: 21
Pages: 571-80
Related Report
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[Journal Article] A nonerythropoietic derivative of erythropoietin inhibits tubulointerstitial fibrosis in remnant kidney.2012
Author(s)
Imamura R, Isaka Y, Sandoval RM, Ichimaru N, Abe T, Okumi M, Yazawa K, Kitamura H, Kaimori J, Nonomura N, Rakugi H, Molitoris BA, Takahara S.
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Journal Title
Clin Exp Nephrol.
Volume: 16
Pages: 852-62
NAID
Related Report
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[Journal Article] Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury2012
Author(s)
Abe T, Li XK, Yazawa K, Hatayama N, Xie L, Sato B, Kakuta Y, Tsutahara K, Okumi M, Tsuda H, Kaimori JY, Isaka Y, Natori M, Takahara S, Nonomura N
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Journal Title
Transplantation
Volume: 94
Pages: 14-21
Related Report
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[Journal Article] The blocking of CXCR3 and CCR5 suppresses the infiltration of T lymphocytes in rat renal ischemia reperfusion.2012
Author(s)
Tsutahara K, Okumi M*, Yoichi Kakuta Y, Abe T, Yazawa K, Miyagawa S, Matsunami K, Otsuka H, Kaimori J, Takahara S, Nonomura N.
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Journal Title
Nephrol Dial Transplant
Volume: 27
Pages: 3799-806
Related Report
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[Journal Article] Orally active vitamin d for potential chemoprevention of posttransplant malignancy2012
Author(s)
Obi Y, Ichimaru N, Hamano T, Tomida K, Matsui I, Fujii N, Okumi M, Kaimori JY, Yazawa K, Kokado Y, Tsubakihara Y, Nonomura N, Rakugi H, Takahara S, Isaka Y
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Journal Title
Cancer Prev Res (Phila)
Volume: 5
Pages: 1229-35
Related Report
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[Journal Article] Tolerogenicity of donor major histocompatibility complex-matched skin grafts in previously tolerant Massachusetts general hospital miniature swine2012
Author(s)
Weiner J, Scalea J, Ishikawa Y, Okumi M, Griesemer A, Hirakata A, Etter J, Gillon B, Moran S, Shimizu A, Yamada K, Sachs DH
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Journal Title
Transplantation
Volume: 94
Pages: 1192-9
Related Report
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[Journal Article] Epigallocatechin-3-gallate protects kidneys from ischemia reperfusion injury by HO-1 upregulation and inhibition of macrophage infiltration.2011
Author(s)
Kakuta Y, Okumi M*, Isaka Y, Tsutahara K, Abe T, Yazawa K, Ichimaru N, Matsumura K, Hyon SH, Takahara S, Nonomura N
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Journal Title
Transplant Int.
Volume: 24
Pages: 514-522
Related Report
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[Journal Article] Safety and efficacy of administering the maximal dose of candesartan in renal transplant recipients.2011
Author(s)
Okumi M, Kawada N, Ichimaru N, Kitamura H, Abe T, Imamura R, Kojima Y, Kokado Y, Isaka Y , Rakugi H, Nonomura N, Moriyama T, Takahara S
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Journal Title
Clin Exp Nephrol
Volume: 15
Pages: 907-915
NAID
Related Report
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[Presentation] Multi-Photon Microscopy Based Kidney Live Imaging Identifies a Series of Micro-Circulation Changes in a Rat Acute Kidney Rejection Model2012
Author(s)
J. Y. Kaimori, T. Abe, H. Tsuda, M. Ishii, M. Okumi, K. Yazawa, Y . Isaka, H. Rakugi, N. Nonomura, S. Takahara
Organizer
American Transplant Congress
Place of Presentation
Bosoton, USA
Related Report
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[Presentation] Adipose Tissue ‐Derived Stem Cells Infusion Prevents Acute Cellular Rejection in Rat Kidney Transplantation2012
Author(s)
T . Kato, K. Yazawa, M. Tanemura, Y . Kakuta, K. Tsutahara, M. Okumi, Y . Iwagami, Y . Ohmura, H. Nagano, S. Takahara, Y . Doki, M. Mori, and N. Nonomura.
Organizer
24th International Congress of the Transplantation Congress
Place of Presentation
Berlin, German
Related Report
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[Presentation] Successful Preservation of the Kidney Grafts under Desiccating Conditions with a Mixture of Carbon Monoxide and Oxygen Gases in Rat Kidney Transplantation Model2011
Author(s)
T. Abe, XK .Li, M. Okumi, N. Hatayama, L. Xie, Y. Kakuta, K. Tsutahara, K. Yazawa, J. Kaimori, Y. Isaka, S. Takahara, and N. Nonomura
Organizer
American Transplant Congress
Place of Presentation
Philadelphia, USA
Related Report
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[Presentation] Hydrogen-Rich UW Solution Attenuates Renal Cold Ischemia Reperfusion Injury.2011
Author(s)
T. Abe, XK .Li, N. Hatayama, L. Xie, B. Sato, Y. Kakuta, K. Tsutahara, M. Okumi, K. Yazawa, J. Kaimori, M. Natori, S. Takahara, and N. Nonomura.
Organizer
American Transplant Congress
Place of Presentation
Philadelphia, USA
Related Report
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